DegronMD

Uniprot ID: O94966

Source protein: Ubiquitin carboxyl-terminal hydrolase 19

Source gene: USP19

Class: DEG_SCF_FBW7_2

Location: 451:456

E3 ligase: FBXW7

DEGRON score: 0.943

ASA_SCORE: 97.45

COIL: 0.9418

CONS_SCORE: 0.2999

DSS_SCORE: 0.7089

HELIX: 0.0292

FCONS_SCORE: 0.9166

RIG_SCORE: 0.6264

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R446C	TCGA-59-2349	OV	TCGA	VTPKPE	DEG_SCF_FBW7_2	0.6389
p.H442N	TCGA-85-8582	LUSC	TCGA	VTPKPE	DEG_SCF_FBW7_2	0.0833
p.E458D	TCGA-AP-A059	UCEC	TCGA	VTPKPE	DEG_SCF_FBW7_2	0.2778
p.C463Y	TCGA-BD-A2L6	LIHC	TCGA	VTPKPE	DEG_SCF_FBW7_2	0.25
p.P443T	DO228971	LICA	ICGC	VTPKPE	DEG_SCF_FBW7_2	0.1111
p.E461K	DO45515	LUSC	ICGC	VTPKPE	DEG_SCF_FBW7_2	0.6389
p.D445N	DO37130	READ	ICGC	VTPKPE	DEG_SCF_FBW7_2	0.1667
p.V449L	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	VTPKPE	DEG_SCF_FBW7_2	0.2778
p.V449L	ACH-000860	Lung Cancer	CCLE	VTPKPE	DEG_SCF_FBW7_2	0.2778
p.V449L	NCI-H358	lung	COSMIC	VTPKPE	DEG_SCF_FBW7_2	0.2778
p.T452N	T84	large_intestine	COSMIC	VTPKPE	DEG_SCF_FBW7_2	0.8166
p.P447T	HCT-15	large_intestine	COSMIC	VTPKPE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94966	Ubiquitin carboxyl-terminal hydrolase 19	DEG_SCF_FBW7_2	451:456	VTPKPE	FBXW7	0.943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons