DegronMD

Uniprot ID: O94966

Source protein: Ubiquitin carboxyl-terminal hydrolase 19

Source gene: USP19

Class: DEG_SCF_FBW7_2

Location: 915:921

E3 ligase: FBXW7

DEGRON score: 0.9484

ASA_SCORE: 81.0571

COIL: 0.7367

CONS_SCORE: 0.2144

DSS_SCORE: 0.6588

HELIX: 0.1353

FCONS_SCORE: 0.8442

RIG_SCORE: 0.7291

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R911L	TCGA-BA-6869	HNSC	TCGA	LVTPMAE	DEG_SCF_FBW7_2	0.2222
p.C922R	TCGA-DI-A1BU	UCEC	TCGA	LVTPMAE	DEG_SCF_FBW7_2	0.3056
p.H926N	TCGA-EE-A2M6	SKCM	TCGA	LVTPMAE	DEG_SCF_FBW7_2	0.1944
p.Y906C	DO8634	COAD	ICGC	LVTPMAE	DEG_SCF_FBW7_2	0.0833
p.T931A	DO26617	LUSC	ICGC	LVTPMAE	DEG_SCF_FBW7_2	0.0556
p.G928V	DO38887	STAD	ICGC	LVTPMAE	DEG_SCF_FBW7_2	0.1389
p.R919H	DO38336	STAD	ICGC	LVTPMAE	DEG_SCF_FBW7_2	0.8244
p.M919K	NCI-H650	lung	COSMIC	LVTPMAE	DEG_SCF_FBW7_2	0.6951
p.Y931S	KARPAS-299	haematopoietic_and_lymphoid_tissue	COSMIC	LVTPMAE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94966	Ubiquitin carboxyl-terminal hydrolase 19	DEG_SCF_FBW7_2	915:921	LVTPMAE	FBXW7	0.9484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons