DegronMD

Uniprot ID: O75592

Source protein: E3 ubiquitin-protein ligase MYCBP2

Source gene: MYCBP2

Class: LIG_APCC_ABBA_1

Location: 3795:3800

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.766

ASA_SCORE: 6.95

COIL: 0.2283

CONS_SCORE: 0.5372

DSS_SCORE: 0.2477

HELIX: 0.0065

FCONS_SCORE: 1.2699

RIG_SCORE: 0.8479

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H3797Y	TCGA-AG-3893	READ	TCGA	VSVHVD	LIG_APCC_ABBA_1	0.7229
p.P3806S	TCGA-EE-A182	SKCM	TCGA	VSVHVD	LIG_APCC_ABBA_1	0.1667
p.N3785K	DO223732	CESC	ICGC	VSVHVD	LIG_APCC_ABBA_1	0.0556
p.N3785S	DO8264	COAD	ICGC	VSVHVD	LIG_APCC_ABBA_1	0.0556
p.H3798N	DO229009	LICA	ICGC	VSVHVD	LIG_APCC_ABBA_1	0.7423
p.R3803Q	DO23702	LUAD	ICGC	VSVHVD	LIG_APCC_ABBA_1	0.25
p.N3791S	DO45330	LUAD	ICGC	VSVHVD	LIG_APCC_ABBA_1	0.2222
p.L3805I	DO232761	PBCA	ICGC	VSVHVD	LIG_APCC_ABBA_1	0.1944
p.L3805F	DO37430	SKCM	ICGC	VSVHVD	LIG_APCC_ABBA_1	0.1944
p.D3804N	DO50281	SKCM	ICGC	VSVHVD	LIG_APCC_ABBA_1	0.2222
p.H3797N	ACH-000577	Liver Cancer	CCLE	VSVHVD	LIG_APCC_ABBA_1	0.7423
p.H3797N	JHH-2	liver	COSMIC	VSVHVD	LIG_APCC_ABBA_1	0.7423
p.H3797R	ACH-000957	Colon/Colorectal Cancer	CCLE	VSVHVD	LIG_APCC_ABBA_1	0.8244
p.H3797R	LS-180	large_intestine	COSMIC	VSVHVD	LIG_APCC_ABBA_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75592	E3 ubiquitin-protein ligase MYCBP2	LIG_APCC_ABBA_1	3795:3800	VSVHVD	APC,CDC20,FZR1	0.766	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons