DegronMD

Uniprot ID: O75592

Source protein: E3 ubiquitin-protein ligase MYCBP2

Source gene: MYCBP2

Class: LIG_APCC_ABBAyCdc20_2

Location: 3220:3226

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9615

ASA_SCORE: 78.2286

COIL: 0.6009

CONS_SCORE: 0.668

DSS_SCORE: 0.4763

HELIX: 0.3234

FCONS_SCORE: 1.2747

RIG_SCORE: 0.721

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V3214M	TCGA-2W-A8YY	CESC	TCGA	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.V3214M	DO223732	CESC	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.S3236I	TCGA-43-2581	LUSC	TCGA	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S3236I	DO26602	LUSC	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.Y3216D	TCGA-DD-AAD8	LIHC	TCGA	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.Y3216D	DO52226	LIHC	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R3227Q	TCGA-DF-A2KU	UCEC	TCGA	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R3227Q	DO222919	BTCA	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R3227Q	DO223286	UCEC	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.P3223Q	TCGA-EE-A2GR	SKCM	TCGA	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.7035
p.P3223Q	DO37996	SKCM	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.7035
p.A3229T	TCGA-HU-A4GT	STAD	TCGA	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.25
p.A3229T	DO48020	STAD	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.25
p.Q3232K	DO228952	LICA	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.H3217N	DO229015	LICA	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.25
p.P3213T	DO229037	LICA	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G3226D	DO232224	PBCA	ICGC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.7198
p.G3221D	SIDM00422	Hodgkin's Lymphoma	GDSC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.6087
p.G3225R	SIDM00663	Melanoma	GDSC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.6457
p.K3212E	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A3221V	ACH-000898	Gastric Cancer	CCLE	RGNLFGE	LIG_APCC_ABBAyCdc20_2	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75592	E3 ubiquitin-protein ligase MYCBP2	LIG_APCC_ABBAyCdc20_2	3220:3226	RGNLFGE	APC,CDC20,FZR1	0.9615	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons