DegronMD

Uniprot ID: O60296

Source protein: Trafficking kinesin-binding protein 2

Source gene: TRAK2

Class: DEG_SCF_FBW7_1

Location: 525:530

E3 ligase: FBXW7

DEGRON score: 0.8485

ASA_SCORE: 60.6

COIL: 0.7202

CONS_SCORE: 0.4331

DSS_SCORE: 0.257

HELIX: 0.1758

FCONS_SCORE: 1.3181

RIG_SCORE: 0.7928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V521F	TCGA-53-7624	LUAD	TCGA	VTPTES	DEG_SCF_FBW7_1	0.2222
p.V521F	DO25058	LUAD	ICGC	VTPTES	DEG_SCF_FBW7_1	0.2222
p.P527L	TCGA-86-7714	LUAD	TCGA	VTPTES	DEG_SCF_FBW7_1	0.7582
p.P527L	DO24870	LUAD	ICGC	VTPTES	DEG_SCF_FBW7_1	0.7582
p.T528I	DO229010	COCA	ICGC	VTPTES	DEG_SCF_FBW7_1	0.5966
p.T528I	DO229013	COCA	ICGC	VTPTES	DEG_SCF_FBW7_1	0.5966
p.T528I	DO234285	ESAD	ICGC	VTPTES	DEG_SCF_FBW7_1	0.5966
p.T528I	DO229346	LAML	ICGC	VTPTES	DEG_SCF_FBW7_1	0.5966
p.T528I	DO228947	LICA	ICGC	VTPTES	DEG_SCF_FBW7_1	0.5966
p.T528I	DO231007	LUSC	ICGC	VTPTES	DEG_SCF_FBW7_1	0.5966
p.C535Y	DO233797	GACA	ICGC	VTPTES	DEG_SCF_FBW7_1	0.1944
p.P527Q	DO228976	LICA	ICGC	VTPTES	DEG_SCF_FBW7_1	0.7035
p.L531I	SIDM00151	Ovarian Carcinoma	GDSC	VTPTES	DEG_SCF_FBW7_1	0.3056
p.L531I	ACH-000966	Ovarian Cancer	CCLE	VTPTES	DEG_SCF_FBW7_1	0.3056
p.L531I	IGROV-1	ovary	COSMIC	VTPTES	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60296	Trafficking kinesin-binding protein 2	DEG_SCF_FBW7_1	525:530	VTPTES	FBXW7	0.8485	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons