DegronMD

Uniprot ID: Q9UPV9

Source protein: Trafficking kinesin-binding protein 1

Source gene: TRAK1

Class: DEG_SCF_FBW7_1

Location: 786:793

E3 ligase: FBXW7

DEGRON score: 0.976

ASA_SCORE: 85.225

COIL: 0.9514

CONS_SCORE: 0.3352

DSS_SCORE: 0.654

HELIX: 0.0218

FCONS_SCORE: 1.0856

RIG_SCORE: 0.5731

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V777A	TCGA-A5-A1OF	UCEC	TCGA	PMQTPTSS	DEG_SCF_FBW7_1	0.0833
p.V777A	DO42568	UCEC	ICGC	PMQTPTSS	DEG_SCF_FBW7_1	0.0833
p.S803G	TCGA-AP-A051	UCEC	TCGA	PMQTPTSS	DEG_SCF_FBW7_1	0.0556
p.S803G	DO42673	UCEC	ICGC	PMQTPTSS	DEG_SCF_FBW7_1	0.0556
p.S792F	TCGA-EE-A2MS	SKCM	TCGA	PMQTPTSS	DEG_SCF_FBW7_1	0.6871
p.S792F	TCGA-Z2-A8RT	SKCM	TCGA	PMQTPTSS	DEG_SCF_FBW7_1	0.6871
p.S792F	DO37567	SKCM	ICGC	PMQTPTSS	DEG_SCF_FBW7_1	0.6871
p.S792F	DO51301	SKCM	ICGC	PMQTPTSS	DEG_SCF_FBW7_1	0.6871
p.C801F	DO229046	LICA	ICGC	PMQTPTSS	DEG_SCF_FBW7_1	0.1111
p.S796F	DO220854	MELA	ICGC	PMQTPTSS	DEG_SCF_FBW7_1	0.25
p.M787V	SIDM01652	Non-Cancerous	GDSC	PMQTPTSS	DEG_SCF_FBW7_1	0.6097
p.M787V	SIDM00187	Kidney Carcinoma	GDSC	PMQTPTSS	DEG_SCF_FBW7_1	0.6097
p.M787V	ACH-002352	Non-Cancerous	CCLE	PMQTPTSS	DEG_SCF_FBW7_1	0.6097
p.P795S	ACH-001970	Metastasis	CCLE	PMQTPTSS	DEG_SCF_FBW7_1	0.2778
p.P776L	NCI-H1563	lung	COSMIC	PMQTPTSS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_SCF_FBW7_1	786:793	PMQTPTSS	FBXW7	0.976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons