DegronMD

Uniprot ID: Q9UPV9

Source protein: Trafficking kinesin-binding protein 1

Source gene: TRAK1

Class: DEG_SCF_FBW7_1

Location: 704:711

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 101.95

COIL: 0.946

CONS_SCORE: 0.3385

DSS_SCORE: 0.4995

HELIX: 0.0211

FCONS_SCORE: 1.0413

RIG_SCORE: 0.6804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T707M	TCGA-AA-3947	COAD	TCGA	LKSTPVAT	DEG_SCF_FBW7_1	0.8534
p.T707M	TCGA-AJ-A3BH	UCEC	TCGA	LKSTPVAT	DEG_SCF_FBW7_1	0.8534
p.T707M	DO8192	COAD	ICGC	LKSTPVAT	DEG_SCF_FBW7_1	0.8534
p.T707M	DO41638	UCEC	ICGC	LKSTPVAT	DEG_SCF_FBW7_1	0.8534
p.S702N	TCGA-D1-A17K	UCEC	TCGA	LKSTPVAT	DEG_SCF_FBW7_1	0.2778
p.S702N	DO42937	UCEC	ICGC	LKSTPVAT	DEG_SCF_FBW7_1	0.2778
p.P708L	TCGA-EO-A22U	UCEC	TCGA	LKSTPVAT	DEG_SCF_FBW7_1	0.7582
p.P708L	DO43755	UCEC	ICGC	LKSTPVAT	DEG_SCF_FBW7_1	0.7582
p.A721S	DO229019	LICA	ICGC	LKSTPVAT	DEG_SCF_FBW7_1	0.0556
p.S719I	DO229006	LICA	ICGC	LKSTPVAT	DEG_SCF_FBW7_1	0.5556
p.S702R	SIDM00515	Melanoma	GDSC	LKSTPVAT	DEG_SCF_FBW7_1	0.2778
p.S702R	ACH-000401	Skin Cancer	CCLE	LKSTPVAT	DEG_SCF_FBW7_1	0.2778
p.S702R	ACH-001339	Skin Cancer	CCLE	LKSTPVAT	DEG_SCF_FBW7_1	0.2778
p.S702R	COLO-800	skin	COSMIC	LKSTPVAT	DEG_SCF_FBW7_1	0.2778
p.C713R	ACH-000373	Leukemia	CCLE	LKSTPVAT	DEG_SCF_FBW7_1	0.2778
p.C713R	ACH-000452	Esophageal Cancer	CCLE	LKSTPVAT	DEG_SCF_FBW7_1	0.2778
p.V709L	ACH-000950	Colon/Colorectal Cancer	CCLE	LKSTPVAT	DEG_SCF_FBW7_1	0.5654
p.V709A	ACH-001786	Colon/Colorectal Cancer	CCLE	LKSTPVAT	DEG_SCF_FBW7_1	0.5825
p.G705S	OVMIU	ovary	COSMIC	LKSTPVAT	DEG_SCF_FBW7_1	0.6993
p.M717V	769-P	kidney	COSMIC	LKSTPVAT	DEG_SCF_FBW7_1	0.1667
p.R706Q	SCC-9	upper_aerodigestive_tract	COSMIC	LKSTPVAT	DEG_SCF_FBW7_1	0.7329
p.Y713C	CCK-81	large_intestine	COSMIC	LKSTPVAT	DEG_SCF_FBW7_1	0.2778
p.A694V	SK-MEL-2	skin	COSMIC	LKSTPVAT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_SCF_FBW7_1	704:711	LKSTPVAT	FBXW7	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons