DegronMD

Uniprot ID: Q86UP3

Source protein: Zinc finger homeobox protein 4

Source gene: ZFHX4

Class: DEG_SCF_FBW7_2

Location: 2806:2813

E3 ligase: FBXW7

DEGRON score: 0.9935

ASA_SCORE: 89.8125

COIL: 0.9091

CONS_SCORE: 0.3042

DSS_SCORE: 0.4898

HELIX: 0.0556

FCONS_SCORE: 0.9825

RIG_SCORE: 0.723

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M2823I	TCGA-17-Z015	LUAD	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.0556
p.I2810V	TCGA-18-3416	LUSC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.7076
p.F2800I	TCGA-49-AARE	LUAD	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.1667
p.G2819R	TCGA-56-7731	LUSC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.1667
p.D2799Y	TCGA-60-2709	LUSC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.1389
p.E2822G	TCGA-77-8139	LUSC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.0833
p.T2808K	TCGA-85-6560	LUSC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.7306
p.D2799N	TCGA-A5-A0GP	UCEC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.1389
p.D2799N	TCGA-DK-A6AW	BLCA	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.1389
p.S2805L	TCGA-AP-A056	UCEC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.3056
p.S2805L	TCGA-CA-6718	COAD	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.3056
p.S2805L	TCGA-EE-A3JD	SKCM	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.3056
p.S2805L	TCGA-EY-A1GI	UCEC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.3056
p.G2816R	TCGA-BG-A222	UCEC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.25
p.G2816R	TCGA-ZF-AA4U	BLCA	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.25
p.G2816R	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PATTPTTE	DEG_SCF_FBW7_2	0.25
p.G2816R	ACH-001638	Lymphoma	CCLE	PATTPTTE	DEG_SCF_FBW7_2	0.25
p.G2816R	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	PATTPTTE	DEG_SCF_FBW7_2	0.25
p.A2809T	TCGA-BR-6452	STAD	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.7139
p.A2809T	TCGA-YD-A9TA	SKCM	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.7139
p.E2802D	TCGA-BS-A0UV	UCEC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.2222
p.E2802D	TCGA-D1-A17Q	UCEC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.2222
p.E2802D	TCGA-EO-A22U	UCEC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.2222
p.N2820T	TCGA-DD-A4NQ	LIHC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.1389
p.T2808M	TCGA-DF-A2KN	UCEC	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.7423
p.E2818K	TCGA-FS-A4F5	SKCM	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.3056
p.E2818K	TCGA-FZ-5921	PAAD	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.3056
p.E2818K	SIDM01175	Other Sarcomas	GDSC	PATTPTTE	DEG_SCF_FBW7_2	0.3056
p.E2818K	ACH-002309	Sarcoma	CCLE	PATTPTTE	DEG_SCF_FBW7_2	0.3056
p.E2818K	SW684	soft_tissue	COSMIC	PATTPTTE	DEG_SCF_FBW7_2	0.3056
p.A2813S	TCGA-G4-6295	COAD	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.7588
p.D2817Y	TCGA-LN-A49K	ESCA	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.2222
p.D2817Y	TCGA-R6-A8W5	ESCA	TCGA	PATTPTTE	DEG_SCF_FBW7_2	0.2222
p.P2804R	DO51892	BLCA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.2778
p.L2820I	DO48566	BLCA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.1389
p.L2820I	DO8842	COAD	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.1389
p.L2820I	DO219919	DLBC	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.1389
p.L2820I	DO42400	UCEC	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.1389
p.D2816N	DO228471	BRCA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.25
p.D2816N	DO37711	SKCM	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.25
p.L2800V	DO1902	BRCA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.1667
p.L2823P	DO9972	COAD	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.0556
p.L2800P	DO227779	COCA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.1667
p.C2815Y	DO224639	COCA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.2778
p.L2823H	DO234230	ESAD	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.0556
p.E2796A	DO233746	GACA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.0556
p.P2810H	DO23556	LUAD	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.7694
p.D2801Y	DO26072	LUAD	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.1944
p.P2806R	DO27652	LUSC	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.7512
p.F2819C	DO220878	MELA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.1667
p.V2814I	DO220882	MELA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.3056
p.EV2813EI	DO220882	MELA	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.7454
p.P2804S	DO219241	PRAD	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.2778
p.K2818N	DO43186	UCEC	ICGC	PATTPTTE	DEG_SCF_FBW7_2	0.3056
p.G2819E	SIDM01175	Other Sarcomas	GDSC	PATTPTTE	DEG_SCF_FBW7_2	0.1667
p.G2819E	ACH-002309	Sarcoma	CCLE	PATTPTTE	DEG_SCF_FBW7_2	0.1667
p.G2819E	SW684	soft_tissue	COSMIC	PATTPTTE	DEG_SCF_FBW7_2	0.1667
p.A2813T	SIDM00660	Colorectal Carcinoma	GDSC	PATTPTTE	DEG_SCF_FBW7_2	0.7139
p.A2813T	ACH-000985	Colon/Colorectal Cancer	CCLE	PATTPTTE	DEG_SCF_FBW7_2	0.7139
p.A2813T	LS-411N	large_intestine	COSMIC	PATTPTTE	DEG_SCF_FBW7_2	0.7139
p.S2805T	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	PATTPTTE	DEG_SCF_FBW7_2	0.3056
p.A2813P	ACH-000135	Non-Cancerous	CCLE	PATTPTTE	DEG_SCF_FBW7_2	0.7503
p.P2809L	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	PATTPTTE	DEG_SCF_FBW7_2	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATTPTTE

Degron related mutations and impact score

Drug responses associated with ZFHX4 mutations

All proteins holding degron of PATTPTTE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UP3	Zinc finger homeobox protein 4	DEG_SCF_FBW7_2	2806:2813	PATTPTTE	FBXW7	0.9935	More...