DegronMD

Uniprot ID: Q86UP3

Source protein: Zinc finger homeobox protein 4

Source gene: ZFHX4

Class: DEG_SPOP_SBC_1

Location: 2387:2391

E3 ligase: SPOP

DEGRON score: 0.9738

ASA_SCORE: 87.68

COIL: 0.955

CONS_SCORE: 0.3035

DSS_SCORE: 0.8914

HELIX: 0.019

FCONS_SCORE: 1.1633

RIG_SCORE: 0.4948

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2383Y	TCGA-06-5416	GBM	TCGA	ASTSS	DEG_SPOP_SBC_1	0.2222
p.G2386A	TCGA-55-7907	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	0.3056
p.P2395H	TCGA-78-7150	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	0.2222
p.G2386E	TCGA-FS-A1ZK	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	0.3056
p.A2378S	TCGA-HZ-A77Q	PAAD	TCGA	ASTSS	DEG_SPOP_SBC_1	0.0833
p.P2390S	TCGA-WE-AAA0	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	0.6752
p.P2392R	DO225322	BRCA	ICGC	ASTSS	DEG_SPOP_SBC_1	0.3056
p.P2395S	DO224765	BRCA	ICGC	ASTSS	DEG_SPOP_SBC_1	0.2222
p.S2393F	DO8240	COAD	ICGC	ASTSS	DEG_SPOP_SBC_1	0.2778
p.S2393F	DO25927	LUAD	ICGC	ASTSS	DEG_SPOP_SBC_1	0.2778
p.Q2389R	DO222874	COCA	ICGC	ASTSS	DEG_SPOP_SBC_1	0.7329
p.A2384G	DO234308	ESAD	ICGC	ASTSS	DEG_SPOP_SBC_1	0.25
p.Q2397E	DO233211	GACA	ICGC	ASTSS	DEG_SPOP_SBC_1	0.1667
p.Q2397E	DO52066	HNSC	ICGC	ASTSS	DEG_SPOP_SBC_1	0.1667
p.A2384T	DO14286	HNSC	ICGC	ASTSS	DEG_SPOP_SBC_1	0.25
p.A2384T	DO43306	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	0.25
p.P2401L	DO52193	LIHC	ICGC	ASTSS	DEG_SPOP_SBC_1	0.0556
p.P2401L	DO45319	LUAD	ICGC	ASTSS	DEG_SPOP_SBC_1	0.0556
p.P2394L	DO26993	LUSC	ICGC	ASTSS	DEG_SPOP_SBC_1	0.25
p.T2399N	DO27334	LUSC	ICGC	ASTSS	DEG_SPOP_SBC_1	0.1111
p.G2398D	DO222514	MELA	ICGC	ASTSS	DEG_SPOP_SBC_1	0.1389
p.G2398D	COR-L95	lung	COSMIC	ASTSS	DEG_SPOP_SBC_1	0.1389
p.P2383S	DO51256	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	0.2222
p.S2393Y	DO47769	STAD	ICGC	ASTSS	DEG_SPOP_SBC_1	0.2778
p.S2382N	SIDM00454	Rhabdomyosarcoma	GDSC	ASTSS	DEG_SPOP_SBC_1	0.1944
p.A2381T	SIDM00496	Thyroid Gland Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	0.2778
p.A2381T	HTC-C3	thyroid	COSMIC	ASTSS	DEG_SPOP_SBC_1	0.2778
p.P2379T	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	0.1111
p.P2379T	ACH-000434	Lung Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	0.1111
p.P2379T	NCI-H1915	lung	COSMIC	ASTSS	DEG_SPOP_SBC_1	0.1111
p.P2379L	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	0.1111
p.P2379L	ACH-000434	Lung Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	0.1111
p.P2379L	NCI-H1915	lung	COSMIC	ASTSS	DEG_SPOP_SBC_1	0.1111
p.K2401N	SIDM00898	Breast Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	0.0556
p.K2401N	ACH-000248	Breast Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	0.0556
p.K2401N	AU565	breast	COSMIC	ASTSS	DEG_SPOP_SBC_1	0.0556
p.P2379R	SIDM00685	Glioblastoma	GDSC	ASTSS	DEG_SPOP_SBC_1	0.1111
p.P2379R	ACH-000819	Brain Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	0.1111
p.P2379R	LN-18	central_nervous_system	COSMIC	ASTSS	DEG_SPOP_SBC_1	0.1111
p.S2382R	SIDM00554	Ovarian Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	0.1944
p.S2382R	ACH-000524	Ovarian Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	0.1944
p.S2382R	KURAMOCHI	ovary	COSMIC	ASTSS	DEG_SPOP_SBC_1	0.1944
p.T2399P	OVK-18	ovary	COSMIC	ASTSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MYU2	Potassium channel subfamily U member 1	DEG_SPOP_SBC_1	659:663	ASTSS	SPOP	0.9898	More...
P43243	Matrin-3	DEG_SPOP_SBC_1	76:80	ASTSS	SPOP	0.9927	More...
P51965	Ubiquitin-conjugating enzyme E2 E1	DEG_SPOP_SBC_1	8:12	ASTSS	SPOP	0.9054	More...
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	549:553	ASTSS	SPOP	0.9989	More...
Q14766	Latent-transforming growth factor beta-binding protein 1	DEG_SPOP_SBC_1	857:861	ASTSS	SPOP	0.8183	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1426:1430	ASTSS	SPOP	0.9825	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1588:1592	ASTSS	SPOP	0.8933	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	548:552	ASTSS	SPOP	0.9698	More...
Q5HYW2	NHS-like protein 2	DEG_SPOP_SBC_1	527:531	ASTSS	SPOP	0.9546	More...
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_SPOP_SBC_1	804:808	ASTSS	SPOP	0.9808	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	1759:1763	ASTSS	SPOP	0.9982	More...
Q5VV67	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1	DEG_SPOP_SBC_1	615:619	ASTSS	SPOP	0.9821	More...
Q86SQ0	Pleckstrin homology-like domain family B member 2	DEG_SPOP_SBC_1	344:348	ASTSS	SPOP	0.997	More...
Q86UK7	E3 ubiquitin-protein ligase ZNF598	DEG_SPOP_SBC_1	450:454	ASTSS	SPOP	0.9877	More...
Q86UP3	Zinc finger homeobox protein 4	DEG_SPOP_SBC_1	386:390	ASTSS	SPOP	0.9577	More...
Q86UP3	Zinc finger homeobox protein 4	DEG_SPOP_SBC_1	2387:2391	ASTSS	SPOP	0.9738	More...
Q86X51	EZH inhibitory protein	DEG_SPOP_SBC_1	189:193	ASTSS	SPOP	0.9261	More...
Q8IYT8	Serine/threonine-protein kinase ULK2	DEG_SPOP_SBC_1	339:343	ASTSS	SPOP	0.9908	More...
Q93052	Lipoma-preferred partner	DEG_SPOP_SBC_1	213:217	ASTSS	SPOP	0.9931	More...
Q96RS0	Trimethylguanosine synthase	DEG_SPOP_SBC_1	543:547	ASTSS	SPOP	0.8361	More...
Q99569	Plakophilin-4	DEG_SPOP_SBC_1	79:83	ASTSS	SPOP	0.855	More...
Q9BX26	Synaptonemal complex protein 2	DEG_SPOP_SBC_1	632:636	ASTSS	SPOP	0.7586	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	1710:1714	ASTSS	SPOP	0.9886	More...
Q9NXE8	Pre-mRNA-splicing factor CWC25 homolog	DEG_SPOP_SBC_1	395:399	ASTSS	SPOP	0.9445	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	1536:1540	ASTSS	SPOP	0.9582	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	2020:2024	ASTSS	SPOP	0.9147	More...
Q9UMD9	Collagen alpha-1	DEG_SPOP_SBC_1	75:79	ASTSS	SPOP	0.9856	More...
Q9Y6X2	E3 SUMO-protein ligase PIAS3	DEG_SPOP_SBC_1	148:152	ASTSS	SPOP	0.911	More...
Q9Y6Y8	SEC23-interacting protein	DEG_SPOP_SBC_1	13:17	ASTSS	SPOP	0.8563	More...
P0C7U0	Protein ELFN1	DEG_SPOP_SBC_1	638:642	ASTSS	SPOP	0.9866	More...
Q2NL68	Proline and serine-rich protein 3	DEG_SPOP_SBC_1	224:228	ASTSS	SPOP	0.9076	More...
Q7Z3E2	Coiled-coil domain-containing protein 186	DEG_SPOP_SBC_1	8:12	ASTSS	SPOP	0.8056	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	378:382	ASTSS	SPOP	0.9794	More...
P0CG42	Putative protein FAM157B	DEG_SPOP_SBC_1	345:349	ASTSS	SPOP	0.9752	More...
P0CG43	Putative protein FAM157C	DEG_SPOP_SBC_1	348:352	ASTSS	SPOP	0.9203	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASTSS

Degron related mutations and impact score

Drug responses associated with ZFHX4 mutations

All proteins holding degron of ASTSS