DegronMD

Uniprot ID: Q9NXE8

Source protein: Pre-mRNA-splicing factor CWC25 homolog

Source gene: CWC25

Class: DEG_SPOP_SBC_1

Location: 395:399

E3 ligase: SPOP

DEGRON score: 0.9445

ASA_SCORE: 82.02

COIL: 0.8714

CONS_SCORE: 0.4148

DSS_SCORE: 0.4015

HELIX: 0.125

FCONS_SCORE: 0.8768

RIG_SCORE: 0.6727

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S399F	TCGA-EA-A5ZF	CESC	TCGA	ASTSS	DEG_SPOP_SBC_1	0.9093
p.Y409C	SIDM00516	Melanoma	GDSC	ASTSS	DEG_SPOP_SBC_1	0.5
p.Y409C	ACH-002166	Skin Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	0.5
p.L400M	SIDM00522	Small Cell Lung Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	0.3056
p.L400M	SIDM00767	Small Cell Lung Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	0.3056
p.L400M	SIDM01624	Bladder Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	0.3056
p.L400M	SIDM01529	Bladder Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	0.3056
p.L392P	TCGA-CN-A63U	HNSC	TCGA	ASTSS	DEG_SPOP_SBC_1	0.25
p.R389H	TCGA-17-Z007	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	0.1667
p.R389H	TCGA-38-6178	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	0.1667
p.R389H	TCGA-AX-A06F	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	0.1667
p.R389H	TCGA-EY-A1G8	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	0.1667
p.R406Q	TCGA-AZ-6601	COAD	TCGA	ASTSS	DEG_SPOP_SBC_1	0.1389

Showing 1 to 13 of 13 entries

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Drug responses associated with CWC25 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of ASTSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	549:553	ASTSS	SPOP	0.9989	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	378:382	ASTSS	SPOP	0.9794	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	2020:2024	ASTSS	SPOP	0.9147	More...
Q7Z3E2	Coiled-coil domain-containing protein 186	DEG_SPOP_SBC_1	8:12	ASTSS	SPOP	0.8056	More...
Q9UMD9	Collagen alpha-1	DEG_SPOP_SBC_1	75:79	ASTSS	SPOP	0.9856	More...
Q9Y6X2	E3 SUMO-protein ligase PIAS3	DEG_SPOP_SBC_1	148:152	ASTSS	SPOP	0.911	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	1759:1763	ASTSS	SPOP	0.9982	More...
Q86UK7	E3 ubiquitin-protein ligase ZNF598	DEG_SPOP_SBC_1	450:454	ASTSS	SPOP	0.9877	More...
Q86X51	EZH inhibitory protein	DEG_SPOP_SBC_1	189:193	ASTSS	SPOP	0.9261	More...
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_SPOP_SBC_1	804:808	ASTSS	SPOP	0.9808	More...
Q14766	Latent-transforming growth factor beta-binding protein 1	DEG_SPOP_SBC_1	857:861	ASTSS	SPOP	0.8183	More...
Q93052	Lipoma-preferred partner	DEG_SPOP_SBC_1	213:217	ASTSS	SPOP	0.9931	More...
P43243	Matrin-3	DEG_SPOP_SBC_1	76:80	ASTSS	SPOP	0.9927	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	1536:1540	ASTSS	SPOP	0.9582	More...
Q5HYW2	NHS-like protein 2	DEG_SPOP_SBC_1	527:531	ASTSS	SPOP	0.9546	More...
Q5VV67	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1	DEG_SPOP_SBC_1	615:619	ASTSS	SPOP	0.9821	More...
Q99569	Plakophilin-4	DEG_SPOP_SBC_1	79:83	ASTSS	SPOP	0.855	More...
Q86SQ0	Pleckstrin homology-like domain family B member 2	DEG_SPOP_SBC_1	344:348	ASTSS	SPOP	0.997	More...
A8MYU2	Potassium channel subfamily U member 1	DEG_SPOP_SBC_1	659:663	ASTSS	SPOP	0.9898	More...
Q9NXE8	Pre-mRNA-splicing factor CWC25 homolog	DEG_SPOP_SBC_1	395:399	ASTSS	SPOP	0.9445	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1426:1430	ASTSS	SPOP	0.9825	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1588:1592	ASTSS	SPOP	0.8933	More...
Q2NL68	Proline and serine-rich protein 3	DEG_SPOP_SBC_1	224:228	ASTSS	SPOP	0.9076	More...
P0C7U0	Protein ELFN1	DEG_SPOP_SBC_1	638:642	ASTSS	SPOP	0.9866	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	1710:1714	ASTSS	SPOP	0.9886	More...

Showing 1 to 25 of 35 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASTSS

Degron related mutations and impact score

Drug responses associated with CWC25 mutations

All proteins holding degron of ASTSS