DegronMD - Q8IYT8(ULK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P324Q	TCGA-85-6561	LUSC	TCGA	PPNY	ITCH	328:331	Mutation rewiring degron network	0.2222
p.P324Q	DO26518	LUSC	ICGC	PPNY	ITCH	328:331	Mutation rewiring degron network	0.2222
p.L321V	TCGA-AA-3977	COAD	TCGA	PPNY	ITCH	328:331	Mutation rewiring degron network	0.1389
p.L321V	DO8730	COAD	ICGC	PPNY	ITCH	328:331	Mutation rewiring degron network	0.1389
p.D352E	TCGA-AP-A1DV	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.0833
p.D352E	DO43186	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.0833
p.K344N	TCGA-AX-A05Z	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.3056
p.K344N	TCGA-B5-A1MR	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.3056
p.K344N	DO40884	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.3056
p.K344N	DO41758	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.3056
p.D337Y	TCGA-AX-A1C8	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.2778
p.D337Y	TCGA-AX-A1C8	UCEC	TCGA	PPNY	ITCH	328:331	Mutation rewiring degron network	0.1667
p.D337Y	TCGA-EO-A22X	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.2778
p.D337Y	TCGA-EO-A22X	UCEC	TCGA	PPNY	ITCH	328:331	Mutation rewiring degron network	0.1667
p.D337Y	DO43338	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.2778
p.D337Y	DO43338	UCEC	ICGC	PPNY	ITCH	328:331	Mutation rewiring degron network	0.1667
p.D337Y	DO43907	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.2778
p.D337Y	DO43907	UCEC	ICGC	PPNY	ITCH	328:331	Mutation rewiring degron network	0.1667
p.P394S	TCGA-CI-6624	READ	TCGA	VSPHSE	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.6752
p.P394S	DO37130	READ	ICGC	VSPHSE	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.6752
p.D337H	TCGA-D8-A27G	BRCA	TCGA	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.2778
p.D337H	TCGA-D8-A27G	BRCA	TCGA	PPNY	ITCH	328:331	Mutation rewiring degron network	0.1667
p.D337H	DO5465	BRCA	ICGC	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.2778
p.D337H	DO5465	BRCA	ICGC	PPNY	ITCH	328:331	Mutation rewiring degron network	0.1667
p.S347Y	TCGA-F5-6814	READ	TCGA	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.2222
p.S347Y	DO36556	READ	ICGC	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.2222
p.T405A	DO227996	COCA	ICGC	VSPHSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.1111
p.S338Y	DO229025	LICA	ICGC	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.3056
p.S338Y	DO229025	LICA	ICGC	PPNY	ITCH	328:331	Mutation rewiring degron network	0.1389
p.D349E	DO229032	LICA	ICGC	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1667
p.V383L	DO228887	LICA	ICGC	VSPHSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0833
p.S342C	DO231232	THCA	ICGC	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.7541
p.T350M	SIDM00373	Endometrial Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1389
p.T350M	ACH-000974	Endometrial/Uterine Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1389
p.I407V	SIDM00845	Burkitt's Lymphoma	GDSC	VSPHSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0556
p.I407V	ACH-000992	Head and Neck Cancer	CCLE	VSPHSE	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0556
p.N320S	SIDM01608	Endometrial Carcinoma	GDSC	PPNY	ITCH	328:331	Mutation rewiring degron network	0.1111
p.N320S	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPNY	ITCH	328:331	Mutation rewiring degron network	0.1111

Kaplan plot for ULK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ULK2

UniProt ID: Q8IYT8

Entrez ID: 9706

Protein name: Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ULK2 in