DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPNY
Uniprot ID:
Q8IYT8
Source protein:
Serine/threonine-protein kinase ULK2
Source gene:
ULK2
Class:
ITCH
Location:
328:331
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9962
ASA_SCORE:
84.425
COIL:
0.7345
CONS_SCORE:
0.3325
DSS_SCORE:
0.6447
HELIX:
0.2228
FCONS_SCORE:
1.202
RIG_SCORE:
0.6284
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P324Q
TCGA-85-6561
LUSC
TCGA
PPNY
ITCH
0.2222
p.P324Q
DO26518
LUSC
ICGC
PPNY
ITCH
0.2222
p.D337Y
TCGA-AX-A1C8
UCEC
TCGA
PPNY
ITCH
0.1667
p.D337Y
TCGA-EO-A22X
UCEC
TCGA
PPNY
ITCH
0.1667
p.D337Y
DO43338
UCEC
ICGC
PPNY
ITCH
0.1667
p.D337Y
DO43907
UCEC
ICGC
PPNY
ITCH
0.1667
p.D337H
TCGA-D8-A27G
BRCA
TCGA
PPNY
ITCH
0.1667
p.D337H
DO5465
BRCA
ICGC
PPNY
ITCH
0.1667
p.L321V
TCGA-AA-3977
COAD
TCGA
PPNY
ITCH
0.1389
p.L321V
DO8730
COAD
ICGC
PPNY
ITCH
0.1389
p.S338Y
DO229025
LICA
ICGC
PPNY
ITCH
0.1389
p.N320S
SIDM01608
Endometrial Carcinoma
GDSC
PPNY
ITCH
0.1111
p.N320S
ACH-000990
Endometrial/Uterine Cancer
CCLE
PPNY
ITCH
0.1111
Showing 1 to 13 of 13 entries
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Drug responses associated with ULK2 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PPNY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P0J1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
ITCH
386:389
PPNY
ITCH,NEDD4
0.9406
More...
Q04828
Aldo-keto reductase family 1 member C1
ITCH
314:317
PPNY
ITCH,NEDD4
0.8044
More...
P52895
Aldo-keto reductase family 1 member C2
ITCH
314:317
PPNY
ITCH,NEDD4
0.8044
More...
P51168
Amiloride-sensitive sodium channel subunit beta
ITCH
617:620
PPNY
ITCH,NEDD4
0.9982
More...
Q8NCT1
Arrestin domain-containing protein 4
ITCH
350:353
PPNY
ITCH,NEDD4
0.5514
More...
Q96BY6
Dedicator of cytokinesis protein 10
ITCH
814:817
PPNY
ITCH,NEDD4
0.8734
More...
Q8IXQ4
GPALPP motifs-containing protein 1
ITCH
36:39
PPNY
ITCH,NEDD4
0.9835
More...
Q01629
Interferon-induced transmembrane protein 2
ITCH
16:19
PPNY
ITCH,NEDD4
0.8133
More...
Q01628
Interferon-induced transmembrane protein 3
ITCH
17:20
PPNY
ITCH,NEDD4
0.9464
More...
Q96RL7
Intermembrane lipid transfer protein VPS13A
ITCH
2237:2240
PPNY
ITCH,NEDD4
0.8494
More...
Q709C8
Intermembrane lipid transfer protein VPS13C
ITCH
289:292
PPNY
ITCH,NEDD4
0.7061
More...
P41229
Lysine-specific demethylase 5C
ITCH
1324:1327
PPNY
ITCH,NEDD4
0.9873
More...
Q86YW9
Mediator of RNA polymerase II transcription subunit 12-like protein
ITCH
1793:1796
PPNY
ITCH,NEDD4
0.9276
More...
Q14896
Myosin-binding protein C, cardiac-type
ITCH
1169:1172
PPNY
ITCH,NEDD4
0.677
More...
Q8IVL0
Neuron navigator 3
ITCH
284:287
PPNY
ITCH,NEDD4
0.986
More...
Q15788
Nuclear receptor coactivator 1
ITCH
1170:1173
PPNY
ITCH,NEDD4
0.8979
More...
Q15596
Nuclear receptor coactivator 2
ITCH
1302:1305
PPNY
ITCH,NEDD4
0.9823
More...
Q8N543
Prolyl 3-hydroxylase OGFOD1
ITCH
245:248
PPNY
ITCH,NEDD4
0.8436
More...
O60507
Protein-tyrosine sulfotransferase 1
ITCH
332:335
PPNY
ITCH,NEDD4
0.6452
More...
O60704
Protein-tyrosine sulfotransferase 2
ITCH
331:334
PPNY
ITCH,NEDD4
0.5339
More...
Q14517
Protocadherin Fat 1
ITCH
929:932
PPNY
ITCH,NEDD4
0.9472
More...
Q9NYQ8
Protocadherin Fat 2
ITCH
4328:4331
PPNY
ITCH,NEDD4
0.7148
More...
C9JQL5
Putative dispanin subfamily A member 2d
ITCH
17:20
PPNY
ITCH,NEDD4
0.5355
More...
Q5K130
Putative uncharacterized protein CLLU1-AS1
ITCH
55:58
PPNY
ITCH,NEDD4
0.9572
More...
Q92541
RNA polymerase-associated protein RTF1 homolog
ITCH
506:509
PPNY
ITCH,NEDD4
0.7387
More...
Showing 1 to 25 of 33 entries
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