DegronMD - Q9NZJ4(SACS)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W1173S	TCGA-66-2755	LUSC	TCGA	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.1667
p.L903P	TCGA-A5-A0VQ	UCEC	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation altering degron motif	0.6471
p.V1157A	TCGA-A5-A1OF	UCEC	TCGA	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.1389
p.E917D	TCGA-AA-A010	COAD	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation rewiring degron network	0.1667
p.F906L	TCGA-AA-A010	COAD	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation altering degron motif	0.587
p.F906L	TCGA-AP-A1E0	UCEC	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation altering degron motif	0.587
p.D912N	TCGA-AF-A56K	READ	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation rewiring degron network	0.3056
p.R919I	TCGA-AX-A06F	UCEC	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation rewiring degron network	0.1111
p.R919I	TCGA-B5-A11E	UCEC	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation rewiring degron network	0.1111
p.R919I	TCGA-BS-A0UV	UCEC	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation rewiring degron network	0.1111
p.R919I	TCGA-EO-A22X	UCEC	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation rewiring degron network	0.1111
p.R919I	TCGA-EO-A3AY	UCEC	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation rewiring degron network	0.1111
p.C1160Y	TCGA-DI-A1BU	UCEC	TCGA	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.2222
p.L1177V	TCGA-E5-A4TZ	BLCA	TCGA	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.0556
p.S894L	TCGA-E6-A1LX	UCEC	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation rewiring degron network	0.0833
p.K916T	TCGA-KM-8443	KICH	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation substituting flanking lysine	0.3056
p.T893A	TCGA-WS-AB45	COAD	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation rewiring degron network	0.0556
p.Q901E	DO481	BLCA	ICGC	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation rewiring degron network	0.2778
p.T1161M	DO51734	COAD	ICGC	PPNY	ITCH	1164:1167	Mutation substituting flanking lysine	0.3611
p.R899I	DO222884	COCA	ICGC	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation rewiring degron network	0.2222
p.R899I	DO41379	UCEC	ICGC	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation rewiring degron network	0.2222
p.V909G	DO234281	ESAD	ICGC	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation altering degron motif	0.7532
p.M1163T	DO233270	GACA	ICGC	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.3056
p.Q902H	DO233874	GACA	ICGC	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation rewiring degron network	0.3056
p.V906G	DO14252	HNSC	ICGC	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation altering degron motif	0.7532
p.R1157G	DO229502	SKCA	ICGC	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.1389
p.R1157Q	DO47723	STAD	ICGC	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.1389
p.R1157Q	DO41644	UCEC	ICGC	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.1389
p.R1157Q	DO41331	UCEC	ICGC	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.1389
p.E908K	DO40884	UCEC	ICGC	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation altering degron motif	0.7022
p.T912A	DO41331	UCEC	ICGC	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation rewiring degron network	0.3056
p.N1159D	DO43971	UCEC	ICGC	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.1944
p.E1162V	SIDM00993	Plasma Cell Myeloma	GDSC	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.2778
p.E1162V	ACH-000838	Myeloma	CCLE	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.2778
p.E1162V	AMO-1	haematopoietic and lymphoid tissue	COSMIC	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.2778
p.P1158S	SIDM00545	Melanoma	GDSC	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.1667
p.P1158S	ACH-000987	Skin Cancer	CCLE	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.1667
p.P1158S	Mewo	skin	COSMIC	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.1667
p.E917V	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation rewiring degron network	0.1667
p.E917V	NCI-H3122	lung	COSMIC	LRKFLASLT	DEG_APCC_DBOX_1	903:911	Mutation rewiring degron network	0.1667
p.L1177P	SIDM01617	Endometrial Carcinoma	GDSC	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.0556
p.L1177P	ACH-000994	Endometrial/Uterine Cancer	CCLE	PPNY	ITCH	1164:1167	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SACS

UniProt ID: Q9NZJ4

Entrez ID: 26278

Protein name: Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SACS in