DegronMD

Uniprot ID: Q9NZJ4

Source protein: Sacsin

Source gene: SACS

Class: DEG_APCC_DBOX_1

Location: 903:911

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9088

ASA_SCORE: 45.0333

COIL: 0.3542

CONS_SCORE: 0.5151

DSS_SCORE: 0.2743

HELIX: 0.6364

FCONS_SCORE: 1.2081

RIG_SCORE: 0.804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L903P	TCGA-A5-A0VQ	UCEC	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	0.6471
p.E917D	TCGA-AA-A010	COAD	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	0.1667
p.F906L	TCGA-AA-A010	COAD	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	0.587
p.F906L	TCGA-AP-A1E0	UCEC	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	0.587
p.D912N	TCGA-AF-A56K	READ	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	0.3056
p.R919I	TCGA-AX-A06F	UCEC	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	0.1111
p.R919I	TCGA-B5-A11E	UCEC	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	0.1111
p.R919I	TCGA-BS-A0UV	UCEC	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	0.1111
p.R919I	TCGA-EO-A22X	UCEC	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	0.1111
p.R919I	TCGA-EO-A3AY	UCEC	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	0.1111
p.S894L	TCGA-E6-A1LX	UCEC	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	0.0833
p.K916T	TCGA-KM-8443	KICH	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	0.3056
p.T893A	TCGA-WS-AB45	COAD	TCGA	LRKFLASLT	DEG_APCC_DBOX_1	0.0556
p.Q901E	DO481	BLCA	ICGC	LRKFLASLT	DEG_APCC_DBOX_1	0.2778
p.R899I	DO222884	COCA	ICGC	LRKFLASLT	DEG_APCC_DBOX_1	0.2222
p.R899I	DO41379	UCEC	ICGC	LRKFLASLT	DEG_APCC_DBOX_1	0.2222
p.V909G	DO234281	ESAD	ICGC	LRKFLASLT	DEG_APCC_DBOX_1	0.7532
p.Q902H	DO233874	GACA	ICGC	LRKFLASLT	DEG_APCC_DBOX_1	0.3056
p.V906G	DO14252	HNSC	ICGC	LRKFLASLT	DEG_APCC_DBOX_1	0.7532
p.E908K	DO40884	UCEC	ICGC	LRKFLASLT	DEG_APCC_DBOX_1	0.7022
p.T912A	DO41331	UCEC	ICGC	LRKFLASLT	DEG_APCC_DBOX_1	0.3056
p.E917V	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	LRKFLASLT	DEG_APCC_DBOX_1	0.1667
p.E917V	NCI-H3122	lung	COSMIC	LRKFLASLT	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZJ4	Sacsin	DEG_APCC_DBOX_1	903:911	LRKFLASLT	APC,CDC20,FZR1	0.9088	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons