DegronMD

Uniprot ID: Q9NZJ4

Source protein: Sacsin

Source gene: SACS

Class: ITCH

Location: 1164:1167

E3 ligase: ITCH,NEDD4

DEGRON score: 0.8832

ASA_SCORE: 77.525

COIL: 0.925

CONS_SCORE: 0.4166

DSS_SCORE: 0.2212

HELIX: 0.0523

FCONS_SCORE: 0.8645

RIG_SCORE: 0.7058

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W1173S	TCGA-66-2755	LUSC	TCGA	PPNY	ITCH	0.1667
p.V1157A	TCGA-A5-A1OF	UCEC	TCGA	PPNY	ITCH	0.1389
p.C1160Y	TCGA-DI-A1BU	UCEC	TCGA	PPNY	ITCH	0.2222
p.L1177V	TCGA-E5-A4TZ	BLCA	TCGA	PPNY	ITCH	0.0556
p.T1161M	DO51734	COAD	ICGC	PPNY	ITCH	0.3611
p.M1163T	DO233270	GACA	ICGC	PPNY	ITCH	0.3056
p.R1157G	DO229502	SKCA	ICGC	PPNY	ITCH	0.1389
p.R1157Q	DO47723	STAD	ICGC	PPNY	ITCH	0.1389
p.R1157Q	DO41644	UCEC	ICGC	PPNY	ITCH	0.1389
p.R1157Q	DO41331	UCEC	ICGC	PPNY	ITCH	0.1389
p.N1159D	DO43971	UCEC	ICGC	PPNY	ITCH	0.1944
p.E1162V	SIDM00993	Plasma Cell Myeloma	GDSC	PPNY	ITCH	0.2778
p.E1162V	ACH-000838	Myeloma	CCLE	PPNY	ITCH	0.2778
p.E1162V	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPNY	ITCH	0.2778
p.P1158S	SIDM00545	Melanoma	GDSC	PPNY	ITCH	0.1667
p.P1158S	ACH-000987	Skin Cancer	CCLE	PPNY	ITCH	0.1667
p.P1158S	Mewo	skin	COSMIC	PPNY	ITCH	0.1667
p.L1177P	SIDM01617	Endometrial Carcinoma	GDSC	PPNY	ITCH	0.0556
p.L1177P	ACH-000994	Endometrial/Uterine Cancer	CCLE	PPNY	ITCH	0.0556

Drug responses associated with SACS mutations

All proteins holding degron of PPNY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60507	Protein-tyrosine sulfotransferase 1	ITCH	332:335	PPNY	ITCH,NEDD4	0.6452	More...
O60704	Protein-tyrosine sulfotransferase 2	ITCH	331:334	PPNY	ITCH,NEDD4	0.5339	More...
O75674	TOM1-like protein 1	ITCH	438:441	PPNY	ITCH,NEDD4	0.998	More...
P08579	U2 small nuclear ribonucleoprotein B''	ITCH	148:151	PPNY	ITCH,NEDD4	0.8982	More...
P41229	Lysine-specific demethylase 5C	ITCH	1324:1327	PPNY	ITCH,NEDD4	0.9873	More...
P51168	Amiloride-sensitive sodium channel subunit beta	ITCH	617:620	PPNY	ITCH,NEDD4	0.9982	More...
P51532	Transcription activator BRG1	ITCH	246:249	PPNY	ITCH,NEDD4	0.5501	More...
P52895	Aldo-keto reductase family 1 member C2	ITCH	314:317	PPNY	ITCH,NEDD4	0.8044	More...
Q01628	Interferon-induced transmembrane protein 3	ITCH	17:20	PPNY	ITCH,NEDD4	0.9464	More...
Q01629	Interferon-induced transmembrane protein 2	ITCH	16:19	PPNY	ITCH,NEDD4	0.8133	More...
Q04828	Aldo-keto reductase family 1 member C1	ITCH	314:317	PPNY	ITCH,NEDD4	0.8044	More...
Q14517	Protocadherin Fat 1	ITCH	929:932	PPNY	ITCH,NEDD4	0.9472	More...
Q14896	Myosin-binding protein C, cardiac-type	ITCH	1169:1172	PPNY	ITCH,NEDD4	0.677	More...
Q15596	Nuclear receptor coactivator 2	ITCH	1302:1305	PPNY	ITCH,NEDD4	0.9823	More...
Q15788	Nuclear receptor coactivator 1	ITCH	1170:1173	PPNY	ITCH,NEDD4	0.8979	More...
Q5VUA4	Zinc finger protein 318	ITCH	775:778	PPNY	ITCH,NEDD4	0.9845	More...
Q709C8	Intermembrane lipid transfer protein VPS13C	ITCH	289:292	PPNY	ITCH,NEDD4	0.7061	More...
Q86VP1	Tax1-binding protein 1	ITCH	738:741	PPNY	ITCH,NEDD4	0.9374	More...
Q86YW9	Mediator of RNA polymerase II transcription subunit 12-like protein	ITCH	1793:1796	PPNY	ITCH,NEDD4	0.9276	More...
Q8IVL0	Neuron navigator 3	ITCH	284:287	PPNY	ITCH,NEDD4	0.986	More...
Q8IYT8	Serine/threonine-protein kinase ULK2	ITCH	328:331	PPNY	ITCH,NEDD4	0.9962	More...
Q8N543	Prolyl 3-hydroxylase OGFOD1	ITCH	245:248	PPNY	ITCH,NEDD4	0.8436	More...
Q8NCT1	Arrestin domain-containing protein 4	ITCH	350:353	PPNY	ITCH,NEDD4	0.5514	More...
Q92541	RNA polymerase-associated protein RTF1 homolog	ITCH	506:509	PPNY	ITCH,NEDD4	0.7387	More...
Q96BY6	Dedicator of cytokinesis protein 10	ITCH	814:817	PPNY	ITCH,NEDD4	0.8734	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	ITCH	2237:2240	PPNY	ITCH,NEDD4	0.8494	More...
Q9NYQ8	Protocadherin Fat 2	ITCH	4328:4331	PPNY	ITCH,NEDD4	0.7148	More...
Q9NZJ4	Sacsin	ITCH	1164:1167	PPNY	ITCH,NEDD4	0.8832	More...
Q9P0J1	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial	ITCH	386:389	PPNY	ITCH,NEDD4	0.9406	More...
C9JQL5	Putative dispanin subfamily A member 2d	ITCH	17:20	PPNY	ITCH,NEDD4	0.5355	More...
Q8IXQ4	GPALPP motifs-containing protein 1	ITCH	36:39	PPNY	ITCH,NEDD4	0.9835	More...
Q5K130	Putative uncharacterized protein CLLU1-AS1	ITCH	55:58	PPNY	ITCH,NEDD4	0.9572	More...
Q8N2G6	Zinc finger CCHC domain-containing protein 24	ITCH	129:132	PPNY	ITCH,NEDD4	0.9708	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPNY

Degron related mutations and impact score

Drug responses associated with SACS mutations

All proteins holding degron of PPNY