DegronMD

Uniprot ID: P51532

Source protein: Transcription activator BRG1

Source gene: SMARCA4

Class: ITCH

Location: 246:249

E3 ligase: ITCH,NEDD4

DEGRON score: 0.5501

ASA_SCORE: 101.975

COIL: 0.9105

CONS_SCORE: 0.2413

DSS_SCORE: 0.7212

HELIX: 0.0555

FCONS_SCORE: 0.9842

RIG_SCORE: 0.4882

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P238S	DO222516	MELA	ICGC	PPNY	ITCH	0.1111
p.G256R	SIDM00217	Colorectal Carcinoma	GDSC	PPNY	ITCH	0.1389
p.G256R	ACH-000999	Colon/Colorectal Cancer	CCLE	PPNY	ITCH	0.1389
p.G256R	SNU-1040	large_intestine	COSMIC	PPNY	ITCH	0.1389
p.A245V	ACH-000964	Leukemia	CCLE	PPNY	ITCH	0.3056
p.P236L	ACH-002024	Colon/Colorectal Cancer	CCLE	PPNY	ITCH	0.0556

Drug responses associated with SMARCA4 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.E623* (No)	GDSC	PFI-3	40.5518
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.E623* (No)	GDSC	PFI3	132.47
SIDM01177	UNCLASSIFIED\|B_cell_leukemia	p.R1192C (No)	GDSC	PFI-3	147.8763
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G1232D (No)	GDSC	PFI-3	130.104
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M272fs*31 (No)	GDSC	PFI-3	79.4353
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M272fs*31 (No)	GDSC	PFI3	351.72
SIDM00210	UNCLASSIFIED\|ovary	p.T910M (No)	GDSC	PFI-3	100.8094
SIDM00210	UNCLASSIFIED\|ovary	p.T910M (No)	GDSC	PFI3	162.15
SIDM00116	LUAD\|lung_NSCLC_adenocarcinoma	p.P270fs*16 (No)	GDSC	PFI-3	141.7397
SIDM00116	LUAD\|lung_NSCLC_adenocarcinoma	p.P270fs*16 (No)	GDSC	PFI3	153.83
SIDM00214	COREAD\|large_intestine	p.P109fs*194 (No)	GDSC	PFI-3	124.0354
SIDM00214	COREAD\|large_intestine	p.P109fs*194 (No)	GDSC	PFI3	133.63
SIDM00932	KIRC\|kidney	p.G1232S (No)	GDSC	PFI-3	124.4636
SIDM00932	KIRC\|kidney	p.G1232S (No)	GDSC	PFI3	250.43
SIDM00781	COREAD\|large_intestine	p.A1186V (No)	GDSC	PFI3	688.48
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.E514* (No)	GDSC	PFI-3	278.7279
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.E514* (No)	GDSC	PFI3	1060.7
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.A1245fs*13 (No)	GDSC	PFI-3	73.4868
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.A1245fs*13 (No)	GDSC	PFI3	118.96
SIDM00145	ALL\|lymphoblastic_leukemia	p.P109fs*194 (No)	GDSC	PFI-3	37.5832
SIDM00145	ALL\|lymphoblastic_leukemia	p.P109fs*194 (No)	GDSC	PFI3	137.96
SIDM00814	ACC\|adrenal_gland	p.Q164* (No)	GDSC	PFI-3	48.5692
SIDM00814	ACC\|adrenal_gland	p.Q164* (No)	GDSC	PFI3	22.895
SIDM00694	UNCLASSIFIED\|digestive_system_other	p.K635fs*9 (No)	GDSC	PFI-3	60.7946
SIDM00694	UNCLASSIFIED\|digestive_system_other	p.K635fs*9 (No)	GDSC	PFI3	69.546
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.L1085fs*32 (No)	GDSC	PFI-3	301.0987
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.L1085fs*32 (No)	GDSC	PFI3	1300.7
SIDM00112	KIRC\|kidney	p.R885L (No)	GDSC	PFI-3	38.2464
SIDM00946	ALL\|T_cell_leukemia	p.Q165* (No)	GDSC	PFI-3	68.7687
SIDM00946	ALL\|T_cell_leukemia	p.Q165* (No)	GDSC	PFI3	72.351
SIDM00783	COREAD\|large_intestine	p.S122fs*7 (No)	GDSC	PFI3	118.53
SIDM01170	OV\|ovary	p.L639fs*7 (No)	GDSC	PFI-3	41.6612
SIDM01170	OV\|ovary	p.L639fs*7 (No)	GDSC	PFI3	168.76
SIDM00933	BRCA\|breast	p.R885H (No)	GDSC	PFI-3	81.8615
SIDM00933	BRCA\|breast	p.R885H (No)	GDSC	PFI3	156.34
SIDM00216	COREAD\|large_intestine	p.R966W (No)	GDSC	PFI3	158.44
SIDM00282	COREAD\|large_intestine	p.G1232D (No)	GDSC	PFI3	216.01
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.K934* (No)	GDSC	PFI-3	80.4494
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.K934* (No)	GDSC	PFI3	399.93
SIDM00474	OV\|ovary	p.Q1185* (No)	GDSC	PFI-3	96.5349
SIDM00238	OV\|ovary	p.P109fs*194 (No)	GDSC	PFI-3	165.7618
SIDM00238	OV\|ovary	p.P109fs*194 (No)	GDSC	PFI3	373.9
SIDM00047	LUAD\|lung_NSCLC_adenocarcinoma	p.E608* (No)	GDSC	PFI-3	109.6087
SIDM00047	LUAD\|lung_NSCLC_adenocarcinoma	p.E608* (No)	GDSC	PFI3	231.63
SIDM00224	MESO\|mesothelioma	p.E449fs*46 (No)	GDSC	PFI3	238.21
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.S828fs*3 (No)	GDSC	PFI-3	158.9008
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.S828fs*3 (No)	GDSC	PFI3	158.38
SIDM00748	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1310* (No)	GDSC	PFI-3	57.8215
SIDM00748	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1310* (No)	GDSC	PFI3	38.556
SIDM00114	MESO\|mesothelioma	p.E1056* (No)	GDSC	PFI-3	256.9894
SIDM00114	MESO\|mesothelioma	p.E1056* (No)	GDSC	PFI3	819.54
SIDM00980	STAD\|stomach	p.E952fs*5 (No)	GDSC	PFI-3	60.4445
SIDM00980	STAD\|stomach	p.E952fs*5 (No)	GDSC	PFI3	257.17
SIDM00119	LUAD\|lung_NSCLC_adenocarcinoma	p.Q418* (No)	GDSC	PFI-3	53.6996
SIDM00119	LUAD\|lung_NSCLC_adenocarcinoma	p.Q418* (No)	GDSC	PFI3	314.4
SIDM00865	SCLC\|lung_small_cell_carcinoma	p.E1310* (No)	GDSC	PFI-3	115.0371
SIDM00865	SCLC\|lung_small_cell_carcinoma	p.E1310* (No)	GDSC	PFI3	126.66
SIDM00903	LUAD\|lung_NSCLC_adenocarcinoma	p.Q729fs*4 (No)	GDSC	PFI-3	68.573
SIDM00903	LUAD\|lung_NSCLC_adenocarcinoma	p.Q729fs*4 (No)	GDSC	PFI3	385.45
SIDM01070	UNCLASSIFIED\|lung_NSCLC_not_specified	p.W1178* (No)	GDSC	PFI-3	131.8981
SIDM01070	UNCLASSIFIED\|lung_NSCLC_not_specified	p.W1178* (No)	GDSC	PFI3	173.69
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.R885L (No)	GDSC	PFI-3	204.3988
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.R885L (No)	GDSC	PFI3	209
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.E463* (No)	GDSC	PFI-3	107.5337
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.E463* (No)	GDSC	PFI3	220.13
SIDM00277	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.E821K (No)	GDSC	PFI3	65.695
SIDM00080	SKCM\|melanoma	p.Q1053fs*53 (No)	GDSC	PFI-3	157.1925
SIDM00080	SKCM\|melanoma	p.Q1053fs*53 (No)	GDSC	PFI3	255.28
SIDM00290	STAD\|stomach	p.K689delK (No)	GDSC	PFI-3	47.5579
SIDM00290	STAD\|stomach	p.K689delK (No)	GDSC	PFI3	129.9
SIDM00509	SCLC\|lung_small_cell_carcinoma	p.A826S (No)	GDSC	PFI3	41.411
SIDM00889	CESC\|cervix	p.N772_L773insN (No)	GDSC	PFI-3	59.1782
SIDM00889	CESC\|cervix	p.N772_L773insN (No)	GDSC	PFI3	199.94
SIDM00327	UNCLASSIFIED\|Hodgkin_lymphoma	p.L921F (No)	GDSC	PFI-3	77.1904
SIDM00327	UNCLASSIFIED\|Hodgkin_lymphoma	p.L921F (No)	GDSC	PFI3	59.735
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A321T (No)	GDSC	PFI-3	50.9052
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A321T (No)	GDSC	PFI3	22.92
SIDM01031	ESCA\|oesophagus	p.N944K (No)	GDSC	PFI-3	96.7477
SIDM00358	STAD\|stomach	p.Q915H (No)	GDSC	PFI-3	125.1931
SIDM00358	STAD\|stomach	p.Q915H (No)	GDSC	PFI3	292.35
SIDM01029	ESCA\|oesophagus	p.T494R (No)	GDSC	PFI-3	44.7951
SIDM01029	ESCA\|oesophagus	p.T494R (No)	GDSC	PFI3	174.59
SIDM00572	STAD\|stomach	p.A136V (No)	GDSC	PFI-3	111.6851
SIDM00572	STAD\|stomach	p.A136V (No)	GDSC	PFI3	159.51
SIDM00210	UNCLASSIFIED\|ovary	p.R1356W (No)	GDSC	PFI-3	100.8094
SIDM00210	UNCLASSIFIED\|ovary	p.R1356W (No)	GDSC	PFI3	162.15
SIDM01086	ALL\|leukemia	p.R167W (No)	GDSC	PFI-3	42.4835
SIDM01086	ALL\|leukemia	p.R167W (No)	GDSC	PFI3	91.199
SIDM00607	LGG\|glioma	p.P285T (No)	GDSC	PFI-3	150.6466
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.E1431* (No)	GDSC	PFI-3	158.705
SIDM00151	OV\|ovary	p.D1448N (No)	GDSC	PFI-3	224.4307
SIDM00151	OV\|ovary	p.D1448N (No)	GDSC	PFI3	51.787
SIDM01032	ESCA\|oesophagus	p.D1235Y (No)	GDSC	PFI3	46.059
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.D543N (No)	GDSC	PFI-3	32.4513
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.D543N (No)	GDSC	PFI3	83.143
SIDM00661	DLBC\|B_cell_lymphoma	p.C891W (No)	GDSC	PFI-3	58.9549
SIDM00683	PRAD\|prostate	p.R726H (No)	GDSC	PFI-3	149.7318
SIDM00683	PRAD\|prostate	p.R726H (No)	GDSC	PFI3	251.37
SIDM00901	UCEC\|endometrium	p.P1488L (No)	GDSC	PFI-3	25.0086
SIDM00901	UCEC\|endometrium	p.P1488L (No)	GDSC	PFI3	103.27
SIDM00745	LUAD\|lung_NSCLC_adenocarcinoma	p.N1164Y (No)	GDSC	PFI-3	9.3231
SIDM00745	LUAD\|lung_NSCLC_adenocarcinoma	p.N1164Y (No)	GDSC	PFI3	1493.2
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.K1598N (No)	GDSC	PFI-3	106.7362
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.K1598N (No)	GDSC	PFI3	94.029
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.E1599* (No)	GDSC	PFI-3	106.7362
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.E1599* (No)	GDSC	PFI3	94.029
SIDM01007	ALL\|lymphoblastic_leukemia	p.E590K (No)	GDSC	PFI-3	71.009
SIDM01007	ALL\|lymphoblastic_leukemia	p.E590K (No)	GDSC	PFI3	44.829
SIDM01007	ALL\|lymphoblastic_leukemia	p.S655P (No)	GDSC	PFI-3	71.009
SIDM01007	ALL\|lymphoblastic_leukemia	p.S655P (No)	GDSC	PFI3	44.829
SIDM00781	COREAD\|large_intestine	p.R1511H (No)	GDSC	PFI3	688.48
SIDM00677	COREAD\|large_intestine	p.R973W (No)	GDSC	PFI-3	144.385
SIDM00677	COREAD\|large_intestine	p.R973W (No)	GDSC	PFI3	257.7
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.G1159W (No)	GDSC	PFI-3	87.8593
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.G1159W (No)	GDSC	PFI3	149.37
SIDM00214	COREAD\|large_intestine	p.R466C (No)	GDSC	PFI-3	124.0354
SIDM00214	COREAD\|large_intestine	p.R466C (No)	GDSC	PFI3	133.63
SIDM00214	COREAD\|large_intestine	p.Y507H (No)	GDSC	PFI-3	124.0354
SIDM00214	COREAD\|large_intestine	p.Y507H (No)	GDSC	PFI3	133.63
SIDM00214	COREAD\|large_intestine	p.M1109V (No)	GDSC	PFI-3	124.0354
SIDM00214	COREAD\|large_intestine	p.M1109V (No)	GDSC	PFI3	133.63
SIDM00176	UNCLASSIFIED\|chondrosarcoma	p.V1377G (No)	GDSC	PFI-3	102.8319
SIDM00176	UNCLASSIFIED\|chondrosarcoma	p.V1377G (No)	GDSC	PFI3	90.816
SIDM01088	UNCLASSIFIED\|endometrium	p.Y120S (No)	GDSC	PFI-3	112.7272
SIDM01088	UNCLASSIFIED\|endometrium	p.Y120S (No)	GDSC	PFI3	142.23
SIDM01088	UNCLASSIFIED\|endometrium	p.R167Q (No)	GDSC	PFI-3	112.7272
SIDM01088	UNCLASSIFIED\|endometrium	p.R167Q (No)	GDSC	PFI3	142.23
SIDM01088	UNCLASSIFIED\|endometrium	p.E1609G (No)	GDSC	PFI-3	112.7272
SIDM01088	UNCLASSIFIED\|endometrium	p.E1609G (No)	GDSC	PFI3	142.23
SIDM00516	SKCM\|melanoma	p.M1233I (No)	GDSC	PFI-3	96.5741
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.K1365delK (No)	GDSC	PFI-3	73.8625
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.K1365delK (No)	GDSC	PFI3	3550.9
SIDM00124	KIRC\|kidney	p.A923P (No)	GDSC	PFI-3	23.1962
SIDM00124	KIRC\|kidney	p.A923P (No)	GDSC	PFI3	422.63
SIDM00151	OV\|ovary	p.E1212delE (No)	GDSC	PFI-3	224.4307
SIDM00151	OV\|ovary	p.E1212delE (No)	GDSC	PFI3	51.787
SIDM01029	ESCA\|oesophagus	p.M76fs*18 (No)	GDSC	PFI-3	44.7951
SIDM01029	ESCA\|oesophagus	p.M76fs*18 (No)	GDSC	PFI3	174.59
SIDM01045	UCEC\|endometrium	p.G603D (No)	GDSC	PFI-3	219.324
SIDM01045	UCEC\|endometrium	p.G603D (No)	GDSC	PFI3	432.37
SIDM01028	ESCA\|oesophagus	p.V1207I (No)	GDSC	PFI3	430.24
SIDM00946	ALL\|T_cell_leukemia	p.S1441T (No)	GDSC	PFI-3	68.7687
SIDM00946	ALL\|T_cell_leukemia	p.S1441T (No)	GDSC	PFI3	72.351
SIDM01055	LGG\|glioma	p.E1531* (No)	GDSC	PFI-3	108.2518
SIDM01055	LGG\|glioma	p.E1531* (No)	GDSC	PFI3	61.257
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.N774K (No)	GDSC	PFI-3	159.3701
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.N774K (No)	GDSC	PFI3	677.83
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.D1450Y (No)	GDSC	PFI-3	123.2675
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.D1450Y (No)	GDSC	PFI3	349.12
SIDM00999	BLCA\|bladder	p.R1203H (No)	GDSC	PFI-3	80.4018
SIDM00999	BLCA\|bladder	p.R1203H (No)	GDSC	PFI3	139.3
SIDM00999	BLCA\|bladder	p.R1477W (No)	GDSC	PFI-3	80.4018
SIDM00999	BLCA\|bladder	p.R1477W (No)	GDSC	PFI3	139.3
SIDM00217	COREAD\|large_intestine	p.G256R (Yes)	GDSC	PFI-3	211.4446
SIDM00217	COREAD\|large_intestine	p.G256R (Yes)	GDSC	PFI3	324.58
SIDM00217	COREAD\|large_intestine	p.A733V (No)	GDSC	PFI-3	211.4446
SIDM00217	COREAD\|large_intestine	p.A733V (No)	GDSC	PFI3	324.58
SIDM00217	COREAD\|large_intestine	p.A778V (No)	GDSC	PFI-3	211.4446
SIDM00217	COREAD\|large_intestine	p.A778V (No)	GDSC	PFI3	324.58
SIDM00217	COREAD\|large_intestine	p.R905H (No)	GDSC	PFI-3	211.4446
SIDM00217	COREAD\|large_intestine	p.R905H (No)	GDSC	PFI3	324.58
SIDM00217	COREAD\|large_intestine	p.R1547H (No)	GDSC	PFI-3	211.4446
SIDM00217	COREAD\|large_intestine	p.R1547H (No)	GDSC	PFI3	324.58
SIDM00094	KIRC\|kidney	p.G1159V (No)	GDSC	PFI-3	52.1218
SIDM00094	KIRC\|kidney	p.G1159V (No)	GDSC	PFI3	233.28
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.R1461H (No)	GDSC	PFI-3	60.1801
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.R1461H (No)	GDSC	PFI3	191.92
SIDM00889	CESC\|cervix	p.M527T (No)	GDSC	PFI-3	59.1782
SIDM00889	CESC\|cervix	p.M527T (No)	GDSC	PFI3	199.94
SIDM00889	CESC\|cervix	p.Q1248R (No)	GDSC	PFI-3	59.1782
SIDM00889	CESC\|cervix	p.Q1248R (No)	GDSC	PFI3	199.94
SIDM00889	CESC\|cervix	p.Q1569* (No)	GDSC	PFI-3	59.1782
SIDM00889	CESC\|cervix	p.Q1569* (No)	GDSC	PFI3	199.94
SIDM00216	COREAD\|large_intestine	p.A379T (No)	GDSC	PFI3	158.44
SIDM00216	COREAD\|large_intestine	p.A1500G (No)	GDSC	PFI3	158.44
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.R1135W (No)	GDSC	PFI-3	58.3105
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.R1135W (No)	GDSC	PFI3	39.444
SIDM00637	DLBC\|B_cell_lymphoma	p.E1255_E1258delEQDE (No)	GDSC	PFI-3	17.5796
SIDM00282	COREAD\|large_intestine	p.R89H (No)	GDSC	PFI3	216.01
SIDM00282	COREAD\|large_intestine	p.E1364A (No)	GDSC	PFI3	216.01
SIDM01088	UNCLASSIFIED\|endometrium	p.K887delK (No)	GDSC	PFI-3	112.7272
SIDM01088	UNCLASSIFIED\|endometrium	p.K887delK (No)	GDSC	PFI3	142.23
SIDM00474	OV\|ovary	p.E780K (No)	GDSC	PFI-3	96.5349
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.K689delK (No)	GDSC	PFI-3	98.9081
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.K689delK (No)	GDSC	PFI3	668.65
SIDM00996	THCA\|thyroid	p.D694E (No)	GDSC	PFI3	142.06
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.D1450E (No)	GDSC	PFI-3	76.7005
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.D1450E (No)	GDSC	PFI3	77.32
SIDM00905	CESC\|cervix	p.R973Q (No)	GDSC	PFI3	196.29
SIDM00322	ESCA\|oesophagus	p.N1486H (No)	GDSC	PFI-3	104.3713
SIDM00458	LAML\|acute_myeloid_leukaemia	p.N926I (No)	GDSC	PFI-3	32.496
SIDM00458	LAML\|acute_myeloid_leukaemia	p.N926I (No)	GDSC	PFI3	95.391
SIDM00658	LUAD\|lung_NSCLC_adenocarcinoma	p.G1162C (No)	GDSC	PFI-3	98.506
SIDM00658	LUAD\|lung_NSCLC_adenocarcinoma	p.G1162C (No)	GDSC	PFI3	144.97
SIDM00534	COREAD\|large_intestine	p.N173H (No)	GDSC	PFI3	214.69
SIDM00487	COREAD\|large_intestine	p.M27I (No)	GDSC	PFI-3	146.2714
SIDM00487	COREAD\|large_intestine	p.M27I (No)	GDSC	PFI3	177.12
SIDM00487	COREAD\|large_intestine	p.V420A (No)	GDSC	PFI-3	146.2714
SIDM00487	COREAD\|large_intestine	p.V420A (No)	GDSC	PFI3	177.12
SIDM00487	COREAD\|large_intestine	p.P647L (No)	GDSC	PFI-3	146.2714
SIDM00487	COREAD\|large_intestine	p.P647L (No)	GDSC	PFI3	177.12
SIDM00487	COREAD\|large_intestine	p.R1477W (No)	GDSC	PFI-3	146.2714
SIDM00487	COREAD\|large_intestine	p.R1477W (No)	GDSC	PFI3	177.12
SIDM01044	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.V268M (No)	GDSC	PFI-3	69.8564
SIDM01044	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.V268M (No)	GDSC	PFI3	144.32
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E861K (No)	GDSC	PFI-3	137.2164
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.G44E (No)	GDSC	PFI-3	42.0277
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.G44E (No)	GDSC	PFI3	179.69
SIDM01110	LIHC\|liver	p.E1614* (No)	GDSC	PFI-3	56.8019
SIDM01110	LIHC\|liver	p.E1614* (No)	GDSC	PFI3	170.05
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.E1481* (No)	GDSC	PFI-3	128.1114
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.E1481* (No)	GDSC	PFI3	357.61
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L1138P (No)	GDSC	PFI-3	87.363
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L1138P (No)	GDSC	PFI3	142.58
SIDM00373	UCEC\|endometrium	p.A322T (No)	GDSC	PFI-3	71.0053
SIDM00373	UCEC\|endometrium	p.A322T (No)	GDSC	PFI3	112.14
SIDM00364	ALL\|lymphoblastic_leukemia	p.A161T (No)	GDSC	PFI-3	40.2331
SIDM00364	ALL\|lymphoblastic_leukemia	p.A161T (No)	GDSC	PFI3	54.548
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.D1235Y (No)	GDSC	PFI-3	204.3988
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.D1235Y (No)	GDSC	PFI3	209
SIDM00537	COREAD\|large_intestine	p.I879V (No)	GDSC	PFI3	128.74
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.D881G (No)	GDSC	PFI-3	56.4075
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.D881G (No)	GDSC	PFI3	43.984
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.G784E (No)	GDSC	PFI-3	193.9323
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.G784E (No)	GDSC	PFI3	96.178
SIDM00043	HNSC\|head_and_neck	p.P1487S (No)	GDSC	PFI-3	47.4218
SIDM00043	HNSC\|head_and_neck	p.P1487S (No)	GDSC	PFI3	226.44
SIDM00193	COREAD\|large_intestine	p.E523K (No)	GDSC	PFI-3	219.9618
SIDM00193	COREAD\|large_intestine	p.E523K (No)	GDSC	PFI3	121.3
SIDM01098	NB\|neuroblastoma	p.R973W (No)	GDSC	PFI-3	99.4964

All proteins holding degron of PPNY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60507	Protein-tyrosine sulfotransferase 1	ITCH	332:335	PPNY	ITCH,NEDD4	0.6452	More...
O60704	Protein-tyrosine sulfotransferase 2	ITCH	331:334	PPNY	ITCH,NEDD4	0.5339	More...
O75674	TOM1-like protein 1	ITCH	438:441	PPNY	ITCH,NEDD4	0.998	More...
P08579	U2 small nuclear ribonucleoprotein B''	ITCH	148:151	PPNY	ITCH,NEDD4	0.8982	More...
P41229	Lysine-specific demethylase 5C	ITCH	1324:1327	PPNY	ITCH,NEDD4	0.9873	More...
P51168	Amiloride-sensitive sodium channel subunit beta	ITCH	617:620	PPNY	ITCH,NEDD4	0.9982	More...
P51532	Transcription activator BRG1	ITCH	246:249	PPNY	ITCH,NEDD4	0.5501	More...
P52895	Aldo-keto reductase family 1 member C2	ITCH	314:317	PPNY	ITCH,NEDD4	0.8044	More...
Q01628	Interferon-induced transmembrane protein 3	ITCH	17:20	PPNY	ITCH,NEDD4	0.9464	More...
Q01629	Interferon-induced transmembrane protein 2	ITCH	16:19	PPNY	ITCH,NEDD4	0.8133	More...
Q04828	Aldo-keto reductase family 1 member C1	ITCH	314:317	PPNY	ITCH,NEDD4	0.8044	More...
Q14517	Protocadherin Fat 1	ITCH	929:932	PPNY	ITCH,NEDD4	0.9472	More...
Q14896	Myosin-binding protein C, cardiac-type	ITCH	1169:1172	PPNY	ITCH,NEDD4	0.677	More...
Q15596	Nuclear receptor coactivator 2	ITCH	1302:1305	PPNY	ITCH,NEDD4	0.9823	More...
Q15788	Nuclear receptor coactivator 1	ITCH	1170:1173	PPNY	ITCH,NEDD4	0.8979	More...
Q5VUA4	Zinc finger protein 318	ITCH	775:778	PPNY	ITCH,NEDD4	0.9845	More...
Q709C8	Intermembrane lipid transfer protein VPS13C	ITCH	289:292	PPNY	ITCH,NEDD4	0.7061	More...
Q86VP1	Tax1-binding protein 1	ITCH	738:741	PPNY	ITCH,NEDD4	0.9374	More...
Q86YW9	Mediator of RNA polymerase II transcription subunit 12-like protein	ITCH	1793:1796	PPNY	ITCH,NEDD4	0.9276	More...
Q8IVL0	Neuron navigator 3	ITCH	284:287	PPNY	ITCH,NEDD4	0.986	More...
Q8IYT8	Serine/threonine-protein kinase ULK2	ITCH	328:331	PPNY	ITCH,NEDD4	0.9962	More...
Q8N543	Prolyl 3-hydroxylase OGFOD1	ITCH	245:248	PPNY	ITCH,NEDD4	0.8436	More...
Q8NCT1	Arrestin domain-containing protein 4	ITCH	350:353	PPNY	ITCH,NEDD4	0.5514	More...
Q92541	RNA polymerase-associated protein RTF1 homolog	ITCH	506:509	PPNY	ITCH,NEDD4	0.7387	More...
Q96BY6	Dedicator of cytokinesis protein 10	ITCH	814:817	PPNY	ITCH,NEDD4	0.8734	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	ITCH	2237:2240	PPNY	ITCH,NEDD4	0.8494	More...
Q9NYQ8	Protocadherin Fat 2	ITCH	4328:4331	PPNY	ITCH,NEDD4	0.7148	More...
Q9NZJ4	Sacsin	ITCH	1164:1167	PPNY	ITCH,NEDD4	0.8832	More...
Q9P0J1	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial	ITCH	386:389	PPNY	ITCH,NEDD4	0.9406	More...
C9JQL5	Putative dispanin subfamily A member 2d	ITCH	17:20	PPNY	ITCH,NEDD4	0.5355	More...
Q8IXQ4	GPALPP motifs-containing protein 1	ITCH	36:39	PPNY	ITCH,NEDD4	0.9835	More...
Q5K130	Putative uncharacterized protein CLLU1-AS1	ITCH	55:58	PPNY	ITCH,NEDD4	0.9572	More...
Q8N2G6	Zinc finger CCHC domain-containing protein 24	ITCH	129:132	PPNY	ITCH,NEDD4	0.9708	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPNY

Degron related mutations and impact score

Drug responses associated with SMARCA4 mutations

All proteins holding degron of PPNY