DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPNY
Uniprot ID:
Q8N2G6
Source protein:
Zinc finger CCHC domain-containing protein 24
Source gene:
ZCCHC24
Class:
ITCH
Location:
129:132
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9708
ASA_SCORE:
80.075
COIL:
0.8983
CONS_SCORE:
0.7276
DSS_SCORE:
0.3378
HELIX:
0.057
FCONS_SCORE:
1.2076
RIG_SCORE:
0.6884
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P129S
TCGA-DA-A1HV
SKCM
TCGA
PPNY
ITCH
0.6752
p.P129S
DO37659
SKCM
ICGC
PPNY
ITCH
0.6752
p.E120K
TCGA-VR-AA7D
ESCA
TCGA
PPNY
ITCH
0.0833
p.N139I
TCGA-YG-AA3N
SKCM
TCGA
PPNY
ITCH
0.1389
p.N139I
DO51298
SKCM
ICGC
PPNY
ITCH
0.1389
p.C137R
DO50327
ESAD
ICGC
PPNY
ITCH
0.1944
p.F138L
DO228974
LICA
ICGC
PPNY
ITCH
0.1667
p.P124H
DO229027
LICA
ICGC
PPNY
ITCH
0.1944
p.R122W
DO41331
UCEC
ICGC
PPNY
ITCH
0.1389
Drug responses associated with ZCCHC24 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPNY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60507
Protein-tyrosine sulfotransferase 1
ITCH
332:335
PPNY
ITCH,NEDD4
0.6452
More...
O60704
Protein-tyrosine sulfotransferase 2
ITCH
331:334
PPNY
ITCH,NEDD4
0.5339
More...
O75674
TOM1-like protein 1
ITCH
438:441
PPNY
ITCH,NEDD4
0.998
More...
P08579
U2 small nuclear ribonucleoprotein B''
ITCH
148:151
PPNY
ITCH,NEDD4
0.8982
More...
P41229
Lysine-specific demethylase 5C
ITCH
1324:1327
PPNY
ITCH,NEDD4
0.9873
More...
P51168
Amiloride-sensitive sodium channel subunit beta
ITCH
617:620
PPNY
ITCH,NEDD4
0.9982
More...
P51532
Transcription activator BRG1
ITCH
246:249
PPNY
ITCH,NEDD4
0.5501
More...
P52895
Aldo-keto reductase family 1 member C2
ITCH
314:317
PPNY
ITCH,NEDD4
0.8044
More...
Q01628
Interferon-induced transmembrane protein 3
ITCH
17:20
PPNY
ITCH,NEDD4
0.9464
More...
Q01629
Interferon-induced transmembrane protein 2
ITCH
16:19
PPNY
ITCH,NEDD4
0.8133
More...
Q04828
Aldo-keto reductase family 1 member C1
ITCH
314:317
PPNY
ITCH,NEDD4
0.8044
More...
Q14517
Protocadherin Fat 1
ITCH
929:932
PPNY
ITCH,NEDD4
0.9472
More...
Q14896
Myosin-binding protein C, cardiac-type
ITCH
1169:1172
PPNY
ITCH,NEDD4
0.677
More...
Q15596
Nuclear receptor coactivator 2
ITCH
1302:1305
PPNY
ITCH,NEDD4
0.9823
More...
Q15788
Nuclear receptor coactivator 1
ITCH
1170:1173
PPNY
ITCH,NEDD4
0.8979
More...
Q5VUA4
Zinc finger protein 318
ITCH
775:778
PPNY
ITCH,NEDD4
0.9845
More...
Q709C8
Intermembrane lipid transfer protein VPS13C
ITCH
289:292
PPNY
ITCH,NEDD4
0.7061
More...
Q86VP1
Tax1-binding protein 1
ITCH
738:741
PPNY
ITCH,NEDD4
0.9374
More...
Q86YW9
Mediator of RNA polymerase II transcription subunit 12-like protein
ITCH
1793:1796
PPNY
ITCH,NEDD4
0.9276
More...
Q8IVL0
Neuron navigator 3
ITCH
284:287
PPNY
ITCH,NEDD4
0.986
More...
Q8IYT8
Serine/threonine-protein kinase ULK2
ITCH
328:331
PPNY
ITCH,NEDD4
0.9962
More...
Q8N543
Prolyl 3-hydroxylase OGFOD1
ITCH
245:248
PPNY
ITCH,NEDD4
0.8436
More...
Q8NCT1
Arrestin domain-containing protein 4
ITCH
350:353
PPNY
ITCH,NEDD4
0.5514
More...
Q92541
RNA polymerase-associated protein RTF1 homolog
ITCH
506:509
PPNY
ITCH,NEDD4
0.7387
More...
Q96BY6
Dedicator of cytokinesis protein 10
ITCH
814:817
PPNY
ITCH,NEDD4
0.8734
More...
Q96RL7
Intermembrane lipid transfer protein VPS13A
ITCH
2237:2240
PPNY
ITCH,NEDD4
0.8494
More...
Q9NYQ8
Protocadherin Fat 2
ITCH
4328:4331
PPNY
ITCH,NEDD4
0.7148
More...
Q9NZJ4
Sacsin
ITCH
1164:1167
PPNY
ITCH,NEDD4
0.8832
More...
Q9P0J1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
ITCH
386:389
PPNY
ITCH,NEDD4
0.9406
More...
C9JQL5
Putative dispanin subfamily A member 2d
ITCH
17:20
PPNY
ITCH,NEDD4
0.5355
More...
Q8IXQ4
GPALPP motifs-containing protein 1
ITCH
36:39
PPNY
ITCH,NEDD4
0.9835
More...
Q5K130
Putative uncharacterized protein CLLU1-AS1
ITCH
55:58
PPNY
ITCH,NEDD4
0.9572
More...
Q8N2G6
Zinc finger CCHC domain-containing protein 24
ITCH
129:132
PPNY
ITCH,NEDD4
0.9708
More...
