DegronMD - Q8N2G6(ZCCHC24)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P129S	TCGA-DA-A1HV	SKCM	TCGA	PPNY	ITCH	129:132	Mutation altering degron motif	0.6752
p.P129S	DO37659	SKCM	ICGC	PPNY	ITCH	129:132	Mutation altering degron motif	0.6752
p.E120K	TCGA-VR-AA7D	ESCA	TCGA	PPNY	ITCH	129:132	Mutation rewiring degron network	0.0833
p.N139I	TCGA-YG-AA3N	SKCM	TCGA	PPNY	ITCH	129:132	Mutation rewiring degron network	0.1389
p.N139I	DO51298	SKCM	ICGC	PPNY	ITCH	129:132	Mutation rewiring degron network	0.1389
p.C137R	DO50327	ESAD	ICGC	PPNY	ITCH	129:132	Mutation rewiring degron network	0.1944
p.F138L	DO228974	LICA	ICGC	PPNY	ITCH	129:132	Mutation rewiring degron network	0.1667
p.P124H	DO229027	LICA	ICGC	PPNY	ITCH	129:132	Mutation rewiring degron network	0.1944
p.R122W	DO41331	UCEC	ICGC	PPNY	ITCH	129:132	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons