DegronMD - Q86YW9(MED12L)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1793H	TCGA-29-1785	OV	TCGA	PPNY	ITCH	1793:1796	Mutation altering degron motif	0.7694
p.P1793H	DO31624	OV	ICGC	PPNY	ITCH	1793:1796	Mutation altering degron motif	0.7694
p.G1824S	TCGA-2J-AAB9	PAAD	TCGA	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.1111
p.G1824S	DO27951	ORCA	ICGC	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.1111
p.G1824S	DO51658	PAAD	ICGC	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.1111
p.V1846A	TCGA-A5-A0G1	UCEC	TCGA	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.0833
p.V1846A	DO42472	UCEC	ICGC	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.0833
p.P1794S	TCGA-AC-A5XS	BRCA	TCGA	PPNY	ITCH	1793:1796	Mutation altering degron motif	0.6752
p.P1794S	DO50023	BRCA	ICGC	PPNY	ITCH	1793:1796	Mutation altering degron motif	0.6752
p.S1831Y	TCGA-AP-A0LM	UCEC	TCGA	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.3056
p.S1831Y	TCGA-QF-A5YS	UCEC	TCGA	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.3056
p.S1831Y	DO43306	UCEC	ICGC	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.3056
p.S1831Y	DO52426	UCEC	ICGC	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.3056
p.H1805R	TCGA-AZ-4315	COAD	TCGA	PPNY	ITCH	1793:1796	Mutation rewiring degron network	0.0833
p.H1805R	DO8842	COAD	ICGC	PPNY	ITCH	1793:1796	Mutation rewiring degron network	0.0833
p.I1799S	TCGA-B9-A69E	KIRP	TCGA	PPNY	ITCH	1793:1796	Mutation rewiring degron network	0.25
p.I1799S	DO44513	KIRP	ICGC	PPNY	ITCH	1793:1796	Mutation rewiring degron network	0.25
p.L1832F	TCGA-BH-A0W7	BRCA	TCGA	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation altering degron motif	0.6981
p.L1832F	DO1272	BRCA	ICGC	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation altering degron motif	0.6981
p.L1827I	TCGA-CE-A481	THCA	TCGA	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.1944
p.L1827I	DO39974	THCA	ICGC	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.1944
p.Q1786H	TCGA-DD-AAE0	LIHC	TCGA	PPNY	ITCH	1793:1796	Mutation rewiring degron network	0.1389
p.Q1786H	DO52253	LIHC	ICGC	PPNY	ITCH	1793:1796	Mutation rewiring degron network	0.1389
p.S1844Y	TCGA-EE-A3J5	SKCM	TCGA	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.1389
p.S1844Y	DO47331	SKCM	ICGC	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.1389
p.G1836D	TCGA-EO-A3B0	UCEC	TCGA	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation altering degron motif	0.6087
p.G1836D	DO219773	UCEC	ICGC	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation altering degron motif	0.6087
p.R1838T	TCGA-GC-A3YS	BLCA	TCGA	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.3056
p.R1838T	DO850	BLCA	ICGC	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.3056
p.F1825V	TCGA-L5-A4OU	ESCA	TCGA	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.1389
p.R1838I	DO52495	COCA	ICGC	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.3056
p.S1800Y	DO222843	MELA	ICGC	PPNY	ITCH	1793:1796	Mutation rewiring degron network	0.2222
p.S1831P	DO46493	OV	ICGC	LTPGGS	DEG_SCF_FBW7_1	1832:1837	Mutation rewiring degron network	0.3056
p.P1798H	SIDM00282	Colorectal Carcinoma	GDSC	PPNY	ITCH	1793:1796	Mutation rewiring degron network	0.2778
p.P1798H	ACH-000998	Colon/Colorectal Cancer	CCLE	PPNY	ITCH	1793:1796	Mutation rewiring degron network	0.2778
p.P1798H	CW-2	large intestine	COSMIC	PPNY	ITCH	1793:1796	Mutation rewiring degron network	0.2778
p.M1803I	SIDM01577	Plasma Cell Myeloma	GDSC	PPNY	ITCH	1793:1796	Mutation rewiring degron network	0.1389
p.M1803I	ACH-000889	Myeloma	CCLE	PPNY	ITCH	1793:1796	Mutation rewiring degron network	0.1389
p.Y1790H	SIDM01690	Plasma Cell Myeloma	GDSC	PPNY	ITCH	1793:1796	Mutation rewiring degron network	0.25

Kaplan plot for MED12L in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MED12L

UniProt ID: Q86YW9

Entrez ID: 116931

Protein name: Mediator of RNA polymerase II transcription subunit 12-like protein (Mediator complex subunit 12-like protein) (Thyroid hormone receptor-associated-like protein) (Trinucleotide repeat-containing gene 11 protein-like)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MED12L in