DegronMD

Uniprot ID: Q86YW9

Source protein: Mediator of RNA polymerase II transcription subunit 12-like protein

Source gene: MED12L

Class: DEG_SCF_FBW7_1

Location: 1832:1837

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 65.0667

COIL: 0.946

CONS_SCORE: 0.3856

DSS_SCORE: 0.5511

HELIX: 0.0313

FCONS_SCORE: 1.1176

RIG_SCORE: 0.6258

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1824S	TCGA-2J-AAB9	PAAD	TCGA	LTPGGS	DEG_SCF_FBW7_1	0.1111
p.G1824S	DO27951	ORCA	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.1111
p.G1824S	DO51658	PAAD	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.1111
p.V1846A	TCGA-A5-A0G1	UCEC	TCGA	LTPGGS	DEG_SCF_FBW7_1	0.0833
p.V1846A	DO42472	UCEC	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.0833
p.S1831Y	TCGA-AP-A0LM	UCEC	TCGA	LTPGGS	DEG_SCF_FBW7_1	0.3056
p.S1831Y	TCGA-QF-A5YS	UCEC	TCGA	LTPGGS	DEG_SCF_FBW7_1	0.3056
p.S1831Y	DO43306	UCEC	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.3056
p.S1831Y	DO52426	UCEC	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.3056
p.L1832F	TCGA-BH-A0W7	BRCA	TCGA	LTPGGS	DEG_SCF_FBW7_1	0.6981
p.L1832F	DO1272	BRCA	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.6981
p.L1827I	TCGA-CE-A481	THCA	TCGA	LTPGGS	DEG_SCF_FBW7_1	0.1944
p.L1827I	DO39974	THCA	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.1944
p.S1844Y	TCGA-EE-A3J5	SKCM	TCGA	LTPGGS	DEG_SCF_FBW7_1	0.1389
p.S1844Y	DO47331	SKCM	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.1389
p.G1836D	TCGA-EO-A3B0	UCEC	TCGA	LTPGGS	DEG_SCF_FBW7_1	0.6087
p.G1836D	DO219773	UCEC	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.6087
p.R1838T	TCGA-GC-A3YS	BLCA	TCGA	LTPGGS	DEG_SCF_FBW7_1	0.3056
p.R1838T	DO850	BLCA	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.3056
p.F1825V	TCGA-L5-A4OU	ESCA	TCGA	LTPGGS	DEG_SCF_FBW7_1	0.1389
p.R1838I	DO52495	COCA	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.3056
p.S1831P	DO46493	OV	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YW9	Mediator of RNA polymerase II transcription subunit 12-like protein	DEG_SCF_FBW7_1	1832:1837	LTPGGS	FBXW7	0.997	More...
Q9H222	ATP-binding cassette sub-family G member 5	DEG_SCF_FBW7_1	7:12	LTPGGS	FBXW7	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons