DegronMD - Q9H222(ABCG5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D3N	TCGA-14-1795	GBM	TCGA	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation rewiring degron network	0.2222
p.D3N	DO13114	GBM	ICGC	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation rewiring degron network	0.2222
p.G14C	TCGA-AX-A1C5	UCEC	TCGA	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation rewiring degron network	0.2778
p.G14C	DO41422	UCEC	ICGC	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation rewiring degron network	0.2778
p.G10R	TCGA-DM-A1D7	COAD	TCGA	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation altering degron motif	0.6457
p.G10R	TCGA-HU-A4GH	STAD	TCGA	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation altering degron motif	0.6457
p.G10R	DO10044	COAD	ICGC	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation altering degron motif	0.6457
p.G10R	DO47743	STAD	ICGC	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation altering degron motif	0.6457
p.G2C	TCGA-G9-6351	PRAD	TCGA	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation blocking phosphorylation signal	0.6389
p.G2C	DO36325	PRAD	ICGC	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation blocking phosphorylation signal	0.6389
p.M13I	TCGA-WE-A8ZX	SKCM	TCGA	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation rewiring degron network	0.3056
p.M13I	DO51291	SKCM	ICGC	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation rewiring degron network	0.3056
p.M13I	SIDM01247	Burkitt's Lymphoma	GDSC	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation rewiring degron network	0.3056
p.M13I	SIDM00779	Colorectal Carcinoma	GDSC	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation rewiring degron network	0.3056
p.M13I	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation rewiring degron network	0.3056
p.M13I	NCI-H716	large intestine	COSMIC	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation rewiring degron network	0.3056
p.L4I	TCGA-WS-AB45	COAD	TCGA	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation rewiring degron network	0.25
p.L4I	DO51734	COAD	ICGC	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation rewiring degron network	0.25
p.G11R	DO222892	BTCA	ICGC	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation altering degron motif	0.6457
p.R11W	DO227802	COCA	ICGC	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation altering degron motif	0.8634
p.N18I	DO234333	ESAD	ICGC	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation rewiring degron network	0.1667
p.F4L	DO220845	MELA	ICGC	LTPGGS	DEG_SCF_FBW7_1	7:12	Mutation rewiring degron network	0.25

Kaplan plot for ABCG5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABCG5

UniProt ID: Q9H222

Entrez ID: 64240

Protein name: ATP-binding cassette sub-family G member 5 (EC 7.6.2.-) (Sterolin-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ABCG5 in