DegronMD

Uniprot ID: Q9H222

Source protein: ATP-binding cassette sub-family G member 5

Source gene: ABCG5

Class: DEG_SCF_FBW7_1

Location: 7:12

E3 ligase: FBXW7

DEGRON score: 0.9976

ASA_SCORE: 72.35

COIL: 0.9372

CONS_SCORE: 0.2462

DSS_SCORE: 0.6727

HELIX: 0.0362

FCONS_SCORE: 1.0013

RIG_SCORE: 0.6153

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D3N	TCGA-14-1795	GBM	TCGA	LTPGGS	DEG_SCF_FBW7_1	0.2222
p.D3N	DO13114	GBM	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.2222
p.G14C	TCGA-AX-A1C5	UCEC	TCGA	LTPGGS	DEG_SCF_FBW7_1	0.2778
p.G14C	DO41422	UCEC	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.2778
p.G10R	TCGA-DM-A1D7	COAD	TCGA	LTPGGS	DEG_SCF_FBW7_1	0.6457
p.G10R	TCGA-HU-A4GH	STAD	TCGA	LTPGGS	DEG_SCF_FBW7_1	0.6457
p.G10R	DO10044	COAD	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.6457
p.G10R	DO47743	STAD	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.6457
p.G2C	TCGA-G9-6351	PRAD	TCGA	LTPGGS	DEG_SCF_FBW7_1	0.6389
p.G2C	DO36325	PRAD	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.6389
p.M13I	TCGA-WE-A8ZX	SKCM	TCGA	LTPGGS	DEG_SCF_FBW7_1	0.3056
p.M13I	DO51291	SKCM	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.3056
p.M13I	SIDM01247	Burkitt's Lymphoma	GDSC	LTPGGS	DEG_SCF_FBW7_1	0.3056
p.M13I	SIDM00779	Colorectal Carcinoma	GDSC	LTPGGS	DEG_SCF_FBW7_1	0.3056
p.M13I	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	LTPGGS	DEG_SCF_FBW7_1	0.3056
p.M13I	NCI-H716	large_intestine	COSMIC	LTPGGS	DEG_SCF_FBW7_1	0.3056
p.L4I	TCGA-WS-AB45	COAD	TCGA	LTPGGS	DEG_SCF_FBW7_1	0.25
p.L4I	DO51734	COAD	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.25
p.G11R	DO222892	BTCA	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.6457
p.R11W	DO227802	COCA	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.8634
p.N18I	DO234333	ESAD	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.1667
p.F4L	DO220845	MELA	ICGC	LTPGGS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YW9	Mediator of RNA polymerase II transcription subunit 12-like protein	DEG_SCF_FBW7_1	1832:1837	LTPGGS	FBXW7	0.997	More...
Q9H222	ATP-binding cassette sub-family G member 5	DEG_SCF_FBW7_1	7:12	LTPGGS	FBXW7	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons