DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPNY
Uniprot ID:
Q14517
Source protein:
Protocadherin Fat 1
Source gene:
FAT1
Class:
ITCH
Location:
929:932
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9472
ASA_SCORE:
59.6
COIL:
0.6165
CONS_SCORE:
0.3783
DSS_SCORE:
0.4285
HELIX:
0.0138
FCONS_SCORE:
0.8064
RIG_SCORE:
0.8094
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R933H
TCGA-D1-A2G0
UCEC
TCGA
PPNY
ITCH
0.3056
p.R933H
DO231899
NBL
ICGC
PPNY
ITCH
0.3056
p.R933H
DO43049
UCEC
ICGC
PPNY
ITCH
0.3056
p.F927C
TCGA-AX-A0J0
UCEC
TCGA
PPNY
ITCH
0.2778
p.F927C
DO41133
UCEC
ICGC
PPNY
ITCH
0.2778
p.F927Y
DO46755
PAEN
ICGC
PPNY
ITCH
0.2778
p.P925R
TCGA-CR-7379
HNSC
TCGA
PPNY
ITCH
0.2222
p.P925R
DO14174
HNSC
ICGC
PPNY
ITCH
0.2222
p.P925S
DO222516
MELA
ICGC
PPNY
ITCH
0.2222
p.L940I
TCGA-77-7141
LUSC
TCGA
PPNY
ITCH
0.1111
p.L940I
DO26450
LUSC
ICGC
PPNY
ITCH
0.1111
p.V920I
TCGA-L5-A8NI
ESCA
TCGA
PPNY
ITCH
0.0833
p.V920F
SIDM00973
Melanoma
GDSC
PPNY
ITCH
0.0833
p.V920F
WM793B
skin
COSMIC
PPNY
ITCH
0.0833
p.D919E
SIDM00973
Melanoma
GDSC
PPNY
ITCH
0.0556
p.D919E
WM793B
skin
COSMIC
PPNY
ITCH
0.0556
Showing 1 to 16 of 16 entries
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Drug responses associated with FAT1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PPNY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P0J1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
ITCH
386:389
PPNY
ITCH,NEDD4
0.9406
More...
Q04828
Aldo-keto reductase family 1 member C1
ITCH
314:317
PPNY
ITCH,NEDD4
0.8044
More...
P52895
Aldo-keto reductase family 1 member C2
ITCH
314:317
PPNY
ITCH,NEDD4
0.8044
More...
P51168
Amiloride-sensitive sodium channel subunit beta
ITCH
617:620
PPNY
ITCH,NEDD4
0.9982
More...
Q8NCT1
Arrestin domain-containing protein 4
ITCH
350:353
PPNY
ITCH,NEDD4
0.5514
More...
Q96BY6
Dedicator of cytokinesis protein 10
ITCH
814:817
PPNY
ITCH,NEDD4
0.8734
More...
Q8IXQ4
GPALPP motifs-containing protein 1
ITCH
36:39
PPNY
ITCH,NEDD4
0.9835
More...
Q01629
Interferon-induced transmembrane protein 2
ITCH
16:19
PPNY
ITCH,NEDD4
0.8133
More...
Q01628
Interferon-induced transmembrane protein 3
ITCH
17:20
PPNY
ITCH,NEDD4
0.9464
More...
Q96RL7
Intermembrane lipid transfer protein VPS13A
ITCH
2237:2240
PPNY
ITCH,NEDD4
0.8494
More...
Q709C8
Intermembrane lipid transfer protein VPS13C
ITCH
289:292
PPNY
ITCH,NEDD4
0.7061
More...
P41229
Lysine-specific demethylase 5C
ITCH
1324:1327
PPNY
ITCH,NEDD4
0.9873
More...
Q86YW9
Mediator of RNA polymerase II transcription subunit 12-like protein
ITCH
1793:1796
PPNY
ITCH,NEDD4
0.9276
More...
Q14896
Myosin-binding protein C, cardiac-type
ITCH
1169:1172
PPNY
ITCH,NEDD4
0.677
More...
Q8IVL0
Neuron navigator 3
ITCH
284:287
PPNY
ITCH,NEDD4
0.986
More...
Q15788
Nuclear receptor coactivator 1
ITCH
1170:1173
PPNY
ITCH,NEDD4
0.8979
More...
Q15596
Nuclear receptor coactivator 2
ITCH
1302:1305
PPNY
ITCH,NEDD4
0.9823
More...
Q8N543
Prolyl 3-hydroxylase OGFOD1
ITCH
245:248
PPNY
ITCH,NEDD4
0.8436
More...
O60507
Protein-tyrosine sulfotransferase 1
ITCH
332:335
PPNY
ITCH,NEDD4
0.6452
More...
O60704
Protein-tyrosine sulfotransferase 2
ITCH
331:334
PPNY
ITCH,NEDD4
0.5339
More...
Q14517
Protocadherin Fat 1
ITCH
929:932
PPNY
ITCH,NEDD4
0.9472
More...
Q9NYQ8
Protocadherin Fat 2
ITCH
4328:4331
PPNY
ITCH,NEDD4
0.7148
More...
C9JQL5
Putative dispanin subfamily A member 2d
ITCH
17:20
PPNY
ITCH,NEDD4
0.5355
More...
Q5K130
Putative uncharacterized protein CLLU1-AS1
ITCH
55:58
PPNY
ITCH,NEDD4
0.9572
More...
Q92541
RNA polymerase-associated protein RTF1 homolog
ITCH
506:509
PPNY
ITCH,NEDD4
0.7387
More...
Showing 1 to 25 of 33 entries
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