DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PPNY
Uniprot ID:
O60704
Source protein:
Protein-tyrosine sulfotransferase 2
Source gene:
TPST2
Class:
ITCH
Location:
331:334
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.5339
ASA_SCORE:
64.35
COIL:
0.913
CONS_SCORE:
0.563
DSS_SCORE:
0.4076
HELIX:
0.05
FCONS_SCORE:
1.006
RIG_SCORE:
0.6372
Degron related mutations and impact score
Show
10
25
50
100
entries
Search:
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P332L
SIDM00088
Prostate Carcinoma
GDSC
PPNY
ITCH
0.7582
p.P332L
ACH-000090
Prostate Cancer
CCLE
PPNY
ITCH
0.7582
p.P332L
PC-3
prostate
COSMIC
PPNY
ITCH
0.7582
p.N330T
DO233856
GACA
ICGC
PPNY
ITCH
0.3056
p.N336I
SIDM00711
Squamous Cell Lung Carcinoma
GDSC
PPNY
ITCH
0.2778
p.N336I
ACH-000727
Lung Cancer
CCLE
PPNY
ITCH
0.2778
p.N336I
NCI-H2066
lung
COSMIC
PPNY
ITCH
0.2778
p.P337T
TCGA-AA-3821
COAD
TCGA
PPNY
ITCH
0.25
p.P337T
DO9314
COAD
ICGC
PPNY
ITCH
0.25
p.D338N
TCGA-DK-A2I4
BLCA
TCGA
PPNY
ITCH
0.2222
p.D338N
DO465
BLCA
ICGC
PPNY
ITCH
0.2222
p.A321V
TCGA-V5-AASW
ESCA
TCGA
PPNY
ITCH
0.0556
Showing 1 to 12 of 12 entries
Previous
1
Next
Drug responses associated with TPST2 mutations
Show
10
25
50
100
entries
Search:
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
Showing 0 to 0 of 0 entries
Previous
Next
All proteins holding degron of PPNY
Show
10
25
50
100
entries
Search:
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P0J1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
ITCH
386:389
PPNY
ITCH,NEDD4
0.9406
More...
Q04828
Aldo-keto reductase family 1 member C1
ITCH
314:317
PPNY
ITCH,NEDD4
0.8044
More...
P52895
Aldo-keto reductase family 1 member C2
ITCH
314:317
PPNY
ITCH,NEDD4
0.8044
More...
P51168
Amiloride-sensitive sodium channel subunit beta
ITCH
617:620
PPNY
ITCH,NEDD4
0.9982
More...
Q8NCT1
Arrestin domain-containing protein 4
ITCH
350:353
PPNY
ITCH,NEDD4
0.5514
More...
Q96BY6
Dedicator of cytokinesis protein 10
ITCH
814:817
PPNY
ITCH,NEDD4
0.8734
More...
Q8IXQ4
GPALPP motifs-containing protein 1
ITCH
36:39
PPNY
ITCH,NEDD4
0.9835
More...
Q01629
Interferon-induced transmembrane protein 2
ITCH
16:19
PPNY
ITCH,NEDD4
0.8133
More...
Q01628
Interferon-induced transmembrane protein 3
ITCH
17:20
PPNY
ITCH,NEDD4
0.9464
More...
Q96RL7
Intermembrane lipid transfer protein VPS13A
ITCH
2237:2240
PPNY
ITCH,NEDD4
0.8494
More...
Q709C8
Intermembrane lipid transfer protein VPS13C
ITCH
289:292
PPNY
ITCH,NEDD4
0.7061
More...
P41229
Lysine-specific demethylase 5C
ITCH
1324:1327
PPNY
ITCH,NEDD4
0.9873
More...
Q86YW9
Mediator of RNA polymerase II transcription subunit 12-like protein
ITCH
1793:1796
PPNY
ITCH,NEDD4
0.9276
More...
Q14896
Myosin-binding protein C, cardiac-type
ITCH
1169:1172
PPNY
ITCH,NEDD4
0.677
More...
Q8IVL0
Neuron navigator 3
ITCH
284:287
PPNY
ITCH,NEDD4
0.986
More...
Q15788
Nuclear receptor coactivator 1
ITCH
1170:1173
PPNY
ITCH,NEDD4
0.8979
More...
Q15596
Nuclear receptor coactivator 2
ITCH
1302:1305
PPNY
ITCH,NEDD4
0.9823
More...
Q8N543
Prolyl 3-hydroxylase OGFOD1
ITCH
245:248
PPNY
ITCH,NEDD4
0.8436
More...
O60507
Protein-tyrosine sulfotransferase 1
ITCH
332:335
PPNY
ITCH,NEDD4
0.6452
More...
O60704
Protein-tyrosine sulfotransferase 2
ITCH
331:334
PPNY
ITCH,NEDD4
0.5339
More...
Q14517
Protocadherin Fat 1
ITCH
929:932
PPNY
ITCH,NEDD4
0.9472
More...
Q9NYQ8
Protocadherin Fat 2
ITCH
4328:4331
PPNY
ITCH,NEDD4
0.7148
More...
C9JQL5
Putative dispanin subfamily A member 2d
ITCH
17:20
PPNY
ITCH,NEDD4
0.5355
More...
Q5K130
Putative uncharacterized protein CLLU1-AS1
ITCH
55:58
PPNY
ITCH,NEDD4
0.9572
More...
Q92541
RNA polymerase-associated protein RTF1 homolog
ITCH
506:509
PPNY
ITCH,NEDD4
0.7387
More...
Showing 1 to 25 of 33 entries
Previous
1
2
Next