DegronMD - Q96BY6(DOCK10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1114H	TCGA-17-Z011	LUAD	TCGA	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation rewiring degron network	0.0833
p.N1300S	TCGA-28-2501	GBM	TCGA	SRASLASLD	DEG_APCC_DBOX_1	1286:1294	Mutation rewiring degron network	0.1667
p.S1129P	TCGA-DD-AADE	LIHC	TCGA	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation altering degron motif	0.6752
p.S1129P	DO219569	LIHC	ICGC	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation altering degron motif	0.6752
p.T1299A	TCGA-FU-A3HZ	CESC	TCGA	SRASLASLD	DEG_APCC_DBOX_1	1286:1294	Mutation rewiring degron network	0.1944
p.T1293A	DO6308	CESC	ICGC	SRASLASLD	DEG_APCC_DBOX_1	1286:1294	Mutation altering degron motif	0.7139
p.K827N	DO230347	COCA	ICGC	PPNY	ITCH	814:817	Mutation blocking ubiquitination signal	0.5
p.K827N	DO234344	ESAD	ICGC	PPNY	ITCH	814:817	Mutation blocking ubiquitination signal	0.5
p.P1114S	DO233652	GACA	ICGC	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation rewiring degron network	0.0833
p.I807M	DO228245	LICA	ICGC	PPNY	ITCH	814:817	Mutation rewiring degron network	0.1389
p.L1113M	DO229031	LICA	ICGC	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation rewiring degron network	0.0556
p.P1123T	DO229037	LICA	ICGC	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation altering degron motif	0.7031
p.A1135V	DO228338	MALY	ICGC	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation rewiring degron network	0.1667
p.A1135V	ACH-002232	Lymphoma	CCLE	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation rewiring degron network	0.1667
p.A1135V	DG-75	haematopoietic and lymphoid tissue	COSMIC	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation rewiring degron network	0.1667
p.S1129L	DO222837	MELA	ICGC	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation altering degron motif	0.7667
p.P821S	SIDM00007	Other Solid Cancers	GDSC	PPNY	ITCH	814:817	Mutation rewiring degron network	0.2222
p.P821S	MCC13	skin	COSMIC	PPNY	ITCH	814:817	Mutation rewiring degron network	0.2222
p.Y818C	SIDM01189	Glioblastoma	GDSC	PPNY	ITCH	814:817	Mutation rewiring degron network	0.3056
p.Y818C	U-87-MG	central nervous system	COSMIC	PPNY	ITCH	814:817	Mutation rewiring degron network	0.3056
p.E1119K	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation rewiring degron network	0.2222
p.E1119K	KYSE-140	oesophagus	COSMIC	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation rewiring degron network	0.2222
p.R1129G	SIDM00850	Gastric Carcinoma	GDSC	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation altering degron motif	0.7568
p.R1129G	AGS	stomach	COSMIC	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation altering degron motif	0.7568
p.M1138L	ACH-000674	Gastric Cancer	CCLE	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation rewiring degron network	0.0833
p.N1296I	ACH-000721	Breast Cancer	CCLE	SRASLASLD	DEG_APCC_DBOX_1	1286:1294	Mutation rewiring degron network	0.2778
p.L1293I	ACH-000807	Brain Cancer	CCLE	SRASLASLD	DEG_APCC_DBOX_1	1286:1294	Mutation altering degron motif	0.6063
p.R1116G	ACH-000880	Gastric Cancer	CCLE	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation rewiring degron network	0.1389
p.R1116G	AGS	stomach	COSMIC	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation rewiring degron network	0.1389
p.M1138I	ACH-000994	Endometrial/Uterine Cancer	CCLE	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation rewiring degron network	0.0833
p.P808S	ACH-001550	Skin Cancer	CCLE	PPNY	ITCH	814:817	Mutation rewiring degron network	0.1667
p.P808S	MCC13	skin	COSMIC	PPNY	ITCH	814:817	Mutation rewiring degron network	0.1667
p.D1131Y	NCI-H650	lung	COSMIC	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation rewiring degron network	0.2778
p.A1129V	DG-75	haematopoietic and lymphoid tissue	COSMIC	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation altering degron motif	0.6936
p.E1134Q	PE/CA-PJ15	upper aerodigestive tract	COSMIC	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation rewiring degron network	0.1944
p.Y805C	U-87-MG	central nervous system	COSMIC	PPNY	ITCH	814:817	Mutation rewiring degron network	0.0833
p.D1137Y	NCI-H650	lung	COSMIC	PLTPSES	DEG_SCF_FBW7_1	1123:1129	Mutation rewiring degron network	0.1111

Kaplan plot for DOCK10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DOCK10

UniProt ID: Q96BY6

Entrez ID: 55619

Protein name: Dedicator of cytokinesis protein 10 (Zizimin-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DOCK10 in