DegronMD

Uniprot ID: Q96BY6

Source protein: Dedicator of cytokinesis protein 10

Source gene: DOCK10

Class: DEG_SCF_FBW7_1

Location: 1123:1129

E3 ligase: FBXW7

DEGRON score: 0.718

ASA_SCORE: 79.3143

COIL: 0.8794

CONS_SCORE: 0.2192

DSS_SCORE: 0.5411

HELIX: 0.0789

FCONS_SCORE: 0.655

RIG_SCORE: 0.6504

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1114H	TCGA-17-Z011	LUAD	TCGA	PLTPSES	DEG_SCF_FBW7_1	0.0833
p.S1129P	TCGA-DD-AADE	LIHC	TCGA	PLTPSES	DEG_SCF_FBW7_1	0.6752
p.S1129P	DO219569	LIHC	ICGC	PLTPSES	DEG_SCF_FBW7_1	0.6752
p.P1114S	DO233652	GACA	ICGC	PLTPSES	DEG_SCF_FBW7_1	0.0833
p.L1113M	DO229031	LICA	ICGC	PLTPSES	DEG_SCF_FBW7_1	0.0556
p.P1123T	DO229037	LICA	ICGC	PLTPSES	DEG_SCF_FBW7_1	0.7031
p.A1135V	DO228338	MALY	ICGC	PLTPSES	DEG_SCF_FBW7_1	0.1667
p.A1135V	ACH-002232	Lymphoma	CCLE	PLTPSES	DEG_SCF_FBW7_1	0.1667
p.A1135V	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PLTPSES	DEG_SCF_FBW7_1	0.1667
p.S1129L	DO222837	MELA	ICGC	PLTPSES	DEG_SCF_FBW7_1	0.7667
p.E1119K	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PLTPSES	DEG_SCF_FBW7_1	0.2222
p.E1119K	KYSE-140	oesophagus	COSMIC	PLTPSES	DEG_SCF_FBW7_1	0.2222
p.R1129G	SIDM00850	Gastric Carcinoma	GDSC	PLTPSES	DEG_SCF_FBW7_1	0.7568
p.R1129G	AGS	stomach	COSMIC	PLTPSES	DEG_SCF_FBW7_1	0.7568
p.M1138L	ACH-000674	Gastric Cancer	CCLE	PLTPSES	DEG_SCF_FBW7_1	0.0833
p.R1116G	ACH-000880	Gastric Cancer	CCLE	PLTPSES	DEG_SCF_FBW7_1	0.1389
p.R1116G	AGS	stomach	COSMIC	PLTPSES	DEG_SCF_FBW7_1	0.1389
p.M1138I	ACH-000994	Endometrial/Uterine Cancer	CCLE	PLTPSES	DEG_SCF_FBW7_1	0.0833
p.D1131Y	NCI-H650	lung	COSMIC	PLTPSES	DEG_SCF_FBW7_1	0.2778
p.A1129V	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PLTPSES	DEG_SCF_FBW7_1	0.6936
p.E1134Q	PE/CA-PJ15	upper_aerodigestive_tract	COSMIC	PLTPSES	DEG_SCF_FBW7_1	0.1944
p.D1137Y	NCI-H650	lung	COSMIC	PLTPSES	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96BY6	Dedicator of cytokinesis protein 10	DEG_SCF_FBW7_1	1123:1129	PLTPSES	FBXW7	0.718	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons