DegronMD

Uniprot ID: Q96BY6

Source protein: Dedicator of cytokinesis protein 10

Source gene: DOCK10

Class: DEG_APCC_DBOX_1

Location: 1286:1294

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9932

ASA_SCORE: 67.0444

COIL: 0.705

CONS_SCORE: 0.3154

DSS_SCORE: 0.4719

HELIX: 0.2186

FCONS_SCORE: 1.0073

RIG_SCORE: 0.6718

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1300S	TCGA-28-2501	GBM	TCGA	SRASLASLD	DEG_APCC_DBOX_1	0.1667
p.T1299A	TCGA-FU-A3HZ	CESC	TCGA	SRASLASLD	DEG_APCC_DBOX_1	0.1944
p.T1293A	DO6308	CESC	ICGC	SRASLASLD	DEG_APCC_DBOX_1	0.7139
p.N1296I	ACH-000721	Breast Cancer	CCLE	SRASLASLD	DEG_APCC_DBOX_1	0.2778
p.L1293I	ACH-000807	Brain Cancer	CCLE	SRASLASLD	DEG_APCC_DBOX_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96BY6	Dedicator of cytokinesis protein 10	DEG_APCC_DBOX_1	1286:1294	SRASLASLD	APC,CDC20,FZR1	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons