DegronMD - O75674(TOM1L1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V218M	TCGA-13-0910	OV	TCGA	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation rewiring degron network	0.1667
p.E231Q	TCGA-4Z-AA7W	BLCA	TCGA	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation altering degron motif	0.6744
p.D235V	TCGA-86-A456	LUAD	TCGA	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation rewiring degron network	0.2222
p.R217P	TCGA-AA-3697	COAD	TCGA	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation rewiring degron network	0.1389
p.E225G	TCGA-AA-3697	COAD	TCGA	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation altering degron motif	0.6087
p.D435G	TCGA-BP-5199	KIRC	TCGA	PPNY	ITCH	438:441	Mutation rewiring degron network	0.25
p.I236M	TCGA-D1-A3JP	UCEC	TCGA	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation rewiring degron network	0.1944
p.L317I	TCGA-DK-A2I4	BLCA	TCGA	PRATLGELN	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.0556
p.G343S	TCGA-EE-A2MJ	SKCM	TCGA	PRATLGELN	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.1111
p.D319N	TCGA-EY-A5W2	UCEC	TCGA	PRATLGELN	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.1111
p.P438L	TCGA-FV-A3R2	LIHC	TCGA	PPNY	ITCH	438:441	Mutation altering degron motif	0.7582
p.A430V	TCGA-IB-7651	PAAD	TCGA	PPNY	ITCH	438:441	Mutation rewiring degron network	0.1111
p.A430V	TCGA-K4-A5RI	BLCA	TCGA	PPNY	ITCH	438:441	Mutation rewiring degron network	0.1111
p.S323I	TCGA-OR-A5KB	ACC	TCGA	PRATLGELN	DEG_APCC_DBOX_1	327:335	Mutation blocking phosphorylation signal	0.6667
p.L223F	TCGA-OR-A5L2	ACC	TCGA	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation rewiring degron network	0.3056
p.M214I	TCGA-S9-A6UA	LGG	TCGA	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation rewiring degron network	0.0556
p.H233Y	TCGA-UF-A719	HNSC	TCGA	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation rewiring degron network	0.2778
p.P317L	DO48368	BLCA	ICGC	PRATLGELN	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.0556
p.H226Y	DO52105	HNSC	ICGC	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation altering degron motif	0.7229
p.D428G	DO19813	KIRC	ICGC	PPNY	ITCH	438:441	Mutation rewiring degron network	0.0556
p.R318Q	DO228650	LICA	ICGC	PRATLGELN	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.0833
p.P431L	DO44994	LIHC	ICGC	PPNY	ITCH	438:441	Mutation rewiring degron network	0.1389
p.P345S	DO218180	ORCA	ICGC	PRATLGELN	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.0556
p.P345S	TOV-21G	ovary	COSMIC	PRATLGELN	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.0556
p.A337V	DO50297	SKCM	ICGC	PRATLGELN	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.2778
p.I229M	DO219769	UCEC	ICGC	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation altering degron motif	0.7618
p.L225R	DO41542	UCEC	ICGC	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation altering degron motif	0.8428
p.K216E	DO41331	UCEC	ICGC	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation rewiring degron network	0.1111
p.M224T	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation altering degron motif	0.7423
p.M224T	SIDM01004	Chronic Myelogenous Leukemia	GDSC	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation altering degron motif	0.7423
p.M224T	SIDM00585	Hepatocellular Carcinoma	GDSC	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation altering degron motif	0.7423
p.M224T	SIDM01727	Chronic Myelogenous Leukemia	GDSC	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation altering degron motif	0.7423
p.M224T	SIDM00164	Biliary Tract Carcinoma	GDSC	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation altering degron motif	0.7423
p.M224T	SIDM01588	Endometrial Carcinoma	GDSC	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation altering degron motif	0.7423
p.M224T	T-T	oesophagus	COSMIC	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation altering degron motif	0.7423
p.M224T	KCL-22	haematopoietic and lymphoid tissue	COSMIC	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation altering degron motif	0.7423
p.M224T	HuH-7	liver	COSMIC	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation altering degron motif	0.7423
p.V447I	KM12	large intestine	COSMIC	PPNY	ITCH	438:441	Mutation rewiring degron network	0.1667
p.A446V	LS-411N	large intestine	COSMIC	PPNY	ITCH	438:441	Mutation rewiring degron network	0.1944
p.M217T	KCL-22	haematopoietic and lymphoid tissue	COSMIC	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation rewiring degron network	0.1389
p.M217T	T-T	oesophagus	COSMIC	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation rewiring degron network	0.1389
p.M217T	HuH-7	liver	COSMIC	MENTPGSE	DEG_SCF_FBW7_2	224:231	Mutation rewiring degron network	0.1389
p.N317S	RKN	ovary	COSMIC	PRATLGELN	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.0556
p.A442V	LS-411N	large intestine	COSMIC	PPNY	ITCH	438:441	Mutation blocking phosphorylation signal	0.75
p.V443I	KM12	large intestine	COSMIC	PPNY	ITCH	438:441	Mutation rewiring degron network	0.2778

Kaplan plot for TOM1L1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TOM1L1

UniProt ID: O75674

Entrez ID: 10040

Protein name: TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TOM1L1 in