DegronMD

Uniprot ID: O75674

Source protein: TOM1-like protein 1

Source gene: TOM1L1

Class: DEG_SCF_FBW7_2

Location: 224:231

E3 ligase: FBXW7

DEGRON score: 0.5176

ASA_SCORE: 86.5625

COIL: 0.7754

CONS_SCORE: 0.3847

DSS_SCORE: 0.405

HELIX: 0.2084

FCONS_SCORE: 0.7533

RIG_SCORE: 0.6597

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L225R	DO41542	UCEC	ICGC	MENTPGSE	DEG_SCF_FBW7_2	0.8428
p.I229M	DO219769	UCEC	ICGC	MENTPGSE	DEG_SCF_FBW7_2	0.7618
p.M224T	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	MENTPGSE	DEG_SCF_FBW7_2	0.7423
p.M224T	SIDM01004	Chronic Myelogenous Leukemia	GDSC	MENTPGSE	DEG_SCF_FBW7_2	0.7423
p.M224T	SIDM00585	Hepatocellular Carcinoma	GDSC	MENTPGSE	DEG_SCF_FBW7_2	0.7423
p.M224T	SIDM01727	Chronic Myelogenous Leukemia	GDSC	MENTPGSE	DEG_SCF_FBW7_2	0.7423
p.M224T	SIDM00164	Biliary Tract Carcinoma	GDSC	MENTPGSE	DEG_SCF_FBW7_2	0.7423
p.M224T	SIDM01588	Endometrial Carcinoma	GDSC	MENTPGSE	DEG_SCF_FBW7_2	0.7423
p.M224T	T-T	oesophagus	COSMIC	MENTPGSE	DEG_SCF_FBW7_2	0.7423
p.M224T	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	MENTPGSE	DEG_SCF_FBW7_2	0.7423
p.M224T	HuH-7	liver	COSMIC	MENTPGSE	DEG_SCF_FBW7_2	0.7423
p.H226Y	DO52105	HNSC	ICGC	MENTPGSE	DEG_SCF_FBW7_2	0.7229
p.E231Q	TCGA-4Z-AA7W	BLCA	TCGA	MENTPGSE	DEG_SCF_FBW7_2	0.6744
p.E225G	TCGA-AA-3697	COAD	TCGA	MENTPGSE	DEG_SCF_FBW7_2	0.6087
p.L223F	TCGA-OR-A5L2	ACC	TCGA	MENTPGSE	DEG_SCF_FBW7_2	0.3056
p.H233Y	TCGA-UF-A719	HNSC	TCGA	MENTPGSE	DEG_SCF_FBW7_2	0.2778
p.D235V	TCGA-86-A456	LUAD	TCGA	MENTPGSE	DEG_SCF_FBW7_2	0.2222
p.I236M	TCGA-D1-A3JP	UCEC	TCGA	MENTPGSE	DEG_SCF_FBW7_2	0.1944
p.V218M	TCGA-13-0910	OV	TCGA	MENTPGSE	DEG_SCF_FBW7_2	0.1667
p.R217P	TCGA-AA-3697	COAD	TCGA	MENTPGSE	DEG_SCF_FBW7_2	0.1389
p.M217T	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	MENTPGSE	DEG_SCF_FBW7_2	0.1389
p.M217T	T-T	oesophagus	COSMIC	MENTPGSE	DEG_SCF_FBW7_2	0.1389
p.M217T	HuH-7	liver	COSMIC	MENTPGSE	DEG_SCF_FBW7_2	0.1389
p.K216E	DO41331	UCEC	ICGC	MENTPGSE	DEG_SCF_FBW7_2	0.1111
p.M214I	TCGA-S9-A6UA	LGG	TCGA	MENTPGSE	DEG_SCF_FBW7_2	0.0556

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Drug responses associated with TOM1L1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of MENTPGSE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75674	TOM1-like protein 1	DEG_SCF_FBW7_2	224:231	MENTPGSE	FBXW7	0.5176	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MENTPGSE

Degron related mutations and impact score

Drug responses associated with TOM1L1 mutations

All proteins holding degron of MENTPGSE