DegronMD

Uniprot ID: O75674

Source protein: TOM1-like protein 1

Source gene: TOM1L1

Class: DEG_APCC_DBOX_1

Location: 327:335

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6185

ASA_SCORE: 86.9222

COIL: 0.7357

CONS_SCORE: 0.3449

DSS_SCORE: 0.6369

HELIX: 0.2368

FCONS_SCORE: 0.9317

RIG_SCORE: 0.7005

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L317I	TCGA-DK-A2I4	BLCA	TCGA	PRATLGELN	DEG_APCC_DBOX_1	0.0556
p.G343S	TCGA-EE-A2MJ	SKCM	TCGA	PRATLGELN	DEG_APCC_DBOX_1	0.1111
p.D319N	TCGA-EY-A5W2	UCEC	TCGA	PRATLGELN	DEG_APCC_DBOX_1	0.1111
p.S323I	TCGA-OR-A5KB	ACC	TCGA	PRATLGELN	DEG_APCC_DBOX_1	0.6667
p.P317L	DO48368	BLCA	ICGC	PRATLGELN	DEG_APCC_DBOX_1	0.0556
p.R318Q	DO228650	LICA	ICGC	PRATLGELN	DEG_APCC_DBOX_1	0.0833
p.P345S	DO218180	ORCA	ICGC	PRATLGELN	DEG_APCC_DBOX_1	0.0556
p.P345S	TOV-21G	ovary	COSMIC	PRATLGELN	DEG_APCC_DBOX_1	0.0556
p.A337V	DO50297	SKCM	ICGC	PRATLGELN	DEG_APCC_DBOX_1	0.2778
p.N317S	RKN	ovary	COSMIC	PRATLGELN	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75674	TOM1-like protein 1	DEG_APCC_DBOX_1	327:335	PRATLGELN	APC,CDC20,FZR1	0.6185	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons