DegronMD - Q92541(RTF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A505D	TCGA-A5-A1OF	UCEC	TCGA	PPNY	ITCH	506:509	Mutation rewiring degron network	0.3056
p.A505D	DO42568	UCEC	ICGC	PPNY	ITCH	506:509	Mutation rewiring degron network	0.3056
p.R204T	TCGA-AN-A0FS	BRCA	TCGA	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.2222
p.R204T	DO3275	BRCA	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.2222
p.E201K	TCGA-C8-A8HQ	BRCA	TCGA	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.3056
p.E201K	TCGA-FU-A2QG	CESC	TCGA	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.3056
p.E201K	DO219623	BRCA	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.3056
p.E201K	DO6253	CESC	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.3056
p.E201G	TCGA-CR-6471	HNSC	TCGA	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.3056
p.E201G	DO15166	HNSC	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.3056
p.A194V	TCGA-DU-6392	LGG	TCGA	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.5825
p.A194V	DO22237	LGG	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.5825
p.M199R	TCGA-EE-A3AG	SKCM	TCGA	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.8632
p.M199R	DO37471	SKCM	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.8632
p.E201V	TCGA-FU-A2QG	CESC	TCGA	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.3056
p.E201V	DO6253	CESC	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.3056
p.E190K	TCGA-SY-A9G5	BLCA	TCGA	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.2778
p.E190K	DO51906	BLCA	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.2778
p.F502L	TCGA-ZB-A966	THYM	TCGA	PPNY	ITCH	506:509	Mutation rewiring degron network	0.2222
p.L208P	DO225257	BRCA	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.1111
p.F209L	DO228331	BRCA	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.0833
p.V496A	DO232224	PBCA	ICGC	PPNY	ITCH	506:509	Mutation rewiring degron network	0.0556
p.Q198K	DO229248	THCA	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.5833
p.R195C	SIDM01088	Endometrial Carcinoma	GDSC	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.719
p.R195C	ACH-000965	Endometrial/Uterine Cancer	CCLE	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.719
p.R195C	RL95-2	endometrium	COSMIC	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.719
p.Q206K	SIDM00254	Neuroblastoma	GDSC	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.1667
p.Q206K	ACH-002283	Neuroblastoma	CCLE	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.1667
p.Q206K	NB5	autonomic ganglia	COSMIC	DRARLEQMT	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.1667
p.K518N	ACH-002026	Endometrial/Uterine Cancer	CCLE	PPNY	ITCH	506:509	Mutation substituting flanking lysine	0.1944

Kaplan plot for RTF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RTF1

UniProt ID: Q92541

Entrez ID: 23168

Protein name: RNA polymerase-associated protein RTF1 homolog

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RTF1 in