DegronMD

Uniprot ID: Q92541

Source protein: RNA polymerase-associated protein RTF1 homolog

Source gene: RTF1

Class: DEG_APCC_DBOX_1

Location: 192:200

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6106

ASA_SCORE: 74.6333

COIL: 0.4073

CONS_SCORE: 0.5502

DSS_SCORE: 0.637

HELIX: 0.5872

FCONS_SCORE: 1.0066

RIG_SCORE: 0.7405

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R204T	TCGA-AN-A0FS	BRCA	TCGA	DRARLEQMT	DEG_APCC_DBOX_1	0.2222
p.R204T	DO3275	BRCA	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	0.2222
p.E201K	TCGA-C8-A8HQ	BRCA	TCGA	DRARLEQMT	DEG_APCC_DBOX_1	0.3056
p.E201K	TCGA-FU-A2QG	CESC	TCGA	DRARLEQMT	DEG_APCC_DBOX_1	0.3056
p.E201K	DO219623	BRCA	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	0.3056
p.E201K	DO6253	CESC	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	0.3056
p.E201G	TCGA-CR-6471	HNSC	TCGA	DRARLEQMT	DEG_APCC_DBOX_1	0.3056
p.E201G	DO15166	HNSC	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	0.3056
p.A194V	TCGA-DU-6392	LGG	TCGA	DRARLEQMT	DEG_APCC_DBOX_1	0.5825
p.A194V	DO22237	LGG	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	0.5825
p.M199R	TCGA-EE-A3AG	SKCM	TCGA	DRARLEQMT	DEG_APCC_DBOX_1	0.8632
p.M199R	DO37471	SKCM	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	0.8632
p.E201V	TCGA-FU-A2QG	CESC	TCGA	DRARLEQMT	DEG_APCC_DBOX_1	0.3056
p.E201V	DO6253	CESC	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	0.3056
p.E190K	TCGA-SY-A9G5	BLCA	TCGA	DRARLEQMT	DEG_APCC_DBOX_1	0.2778
p.E190K	DO51906	BLCA	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	0.2778
p.L208P	DO225257	BRCA	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	0.1111
p.F209L	DO228331	BRCA	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	0.0833
p.Q198K	DO229248	THCA	ICGC	DRARLEQMT	DEG_APCC_DBOX_1	0.5833
p.R195C	SIDM01088	Endometrial Carcinoma	GDSC	DRARLEQMT	DEG_APCC_DBOX_1	0.719
p.R195C	ACH-000965	Endometrial/Uterine Cancer	CCLE	DRARLEQMT	DEG_APCC_DBOX_1	0.719
p.R195C	RL95-2	endometrium	COSMIC	DRARLEQMT	DEG_APCC_DBOX_1	0.719
p.Q206K	SIDM00254	Neuroblastoma	GDSC	DRARLEQMT	DEG_APCC_DBOX_1	0.1667
p.Q206K	ACH-002283	Neuroblastoma	CCLE	DRARLEQMT	DEG_APCC_DBOX_1	0.1667
p.Q206K	NB5	autonomic_ganglia	COSMIC	DRARLEQMT	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92541	RNA polymerase-associated protein RTF1 homolog	DEG_APCC_DBOX_1	192:200	DRARLEQMT	APC,CDC20,FZR1	0.6106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DRARLEQMT

Degron related mutations and impact score

Drug responses associated with RTF1 mutations

All proteins holding degron of DRARLEQMT