DegronMD

Uniprot ID: Q8IYT8

Source protein: Serine/threonine-protein kinase ULK2

Source gene: ULK2

Class: LIG_APCC_ABBA_1

Location: 392:397

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8659

ASA_SCORE: 93.4667

COIL: 0.9163

CONS_SCORE: 0.2734

DSS_SCORE: 0.5095

HELIX: 0.038

FCONS_SCORE: 0.8979

RIG_SCORE: 0.6613

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P394S	TCGA-CI-6624	READ	TCGA	VSPHSE	LIG_APCC_ABBA_1	0.6752
p.P394S	DO37130	READ	ICGC	VSPHSE	LIG_APCC_ABBA_1	0.6752
p.T405A	DO227996	COCA	ICGC	VSPHSE	LIG_APCC_ABBA_1	0.1111
p.V383L	DO228887	LICA	ICGC	VSPHSE	LIG_APCC_ABBA_1	0.0833
p.I407V	SIDM00845	Burkitt's Lymphoma	GDSC	VSPHSE	LIG_APCC_ABBA_1	0.0556
p.I407V	ACH-000992	Head and Neck Cancer	CCLE	VSPHSE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYT8	Serine/threonine-protein kinase ULK2	LIG_APCC_ABBA_1	392:397	VSPHSE	APC,CDC20,FZR1	0.8659	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons