DegronMD - Q14766(LTBP1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V851D	TCGA-44-2655	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	857:861	Mutation rewiring degron network	0.1667
p.L292V	TCGA-4Z-AA7O	BLCA	TCGA	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation altering degron motif	0.5654
p.L292V	DO51865	BLCA	ICGC	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation altering degron motif	0.5654
p.F656L	TCGA-55-8208	LUAD	TCGA	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.1944
p.P850T	TCGA-86-6851	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	857:861	Mutation rewiring degron network	0.1389
p.Q283H	TCGA-A5-A0G1	UCEC	TCGA	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.1667
p.Q283H	DO42472	UCEC	ICGC	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.1667
p.P667S	TCGA-AJ-A3EL	UCEC	TCGA	TFSSCVPDP	DEG_COP1_1	661:669	Mutation altering degron motif	0.6752
p.P667S	TCGA-AP-A1DV	UCEC	TCGA	TFSSCVPDP	DEG_COP1_1	661:669	Mutation altering degron motif	0.6752
p.P667S	TCGA-AZ-4315	COAD	TCGA	TFSSCVPDP	DEG_COP1_1	661:669	Mutation altering degron motif	0.6752
p.P667S	TCGA-B5-A0JY	UCEC	TCGA	TFSSCVPDP	DEG_COP1_1	661:669	Mutation altering degron motif	0.6752
p.P667S	TCGA-EI-6917	READ	TCGA	TFSSCVPDP	DEG_COP1_1	661:669	Mutation altering degron motif	0.6752
p.I672V	TCGA-AJ-A3EL	UCEC	TCGA	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.25
p.T651A	TCGA-AP-A0LM	UCEC	TCGA	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.0556
p.S664G	TCGA-AP-A1DK	UCEC	TCGA	TFSSCVPDP	DEG_COP1_1	661:669	Mutation altering degron motif	0.5882
p.T651I	TCGA-BT-A2LA	BLCA	TCGA	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.0556
p.G657E	TCGA-DF-A2KU	UCEC	TCGA	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.2222
p.S664I	TCGA-DU-6392	LGG	TCGA	TFSSCVPDP	DEG_COP1_1	661:669	Mutation altering degron motif	0.623
p.G655E	TCGA-EE-A3AG	SKCM	TCGA	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.1667
p.G655E	TCGA-FS-A1ZA	SKCM	TCGA	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.1667
p.A857T	TCGA-EJ-7321	PRAD	TCGA	ASTSS	DEG_SPOP_SBC_1	857:861	Mutation altering degron motif	0.7139
p.E674K	TCGA-EO-A22R	UCEC	TCGA	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.1944
p.E674K	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.1944
p.E674K	NCI-H2009	lung	COSMIC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.1944
p.H301L	TCGA-QC-A7B5	SARC	TCGA	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.1389
p.H301L	DO220239	SARC	ICGC	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.1389
p.S294F	TCGA-WE-A8K5	SKCM	TCGA	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation altering degron motif	0.7982
p.S294F	DO51282	SKCM	ICGC	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation altering degron motif	0.7982
p.S858Y	TCGA-X7-A8M3	THYM	TCGA	ASTSS	DEG_SPOP_SBC_1	857:861	Mutation altering degron motif	0.6009
p.R670G	DO2545	BRCA	ICGC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.3056
p.C863Y	DO2485	BRCA	ICGC	ASTSS	DEG_SPOP_SBC_1	857:861	Mutation rewiring degron network	0.2778
p.G662V	DO50090	COAD	ICGC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation altering degron motif	0.7532
p.D871G	DO8264	COAD	ICGC	ASTSS	DEG_SPOP_SBC_1	857:861	Mutation rewiring degron network	0.0556
p.N295T	DO234350	ESAD	ICGC	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.3056
p.R664L	DO234393	ESAD	ICGC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation altering degron motif	0.8428
p.R664P	DO14862	HNSC	ICGC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation altering degron motif	0.7512
p.C852F	DO228974	LICA	ICGC	ASTSS	DEG_SPOP_SBC_1	857:861	Mutation rewiring degron network	0.1944
p.G289V	DO228985	LICA	ICGC	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation altering degron motif	0.7532
p.G289V	ACH-000744	Lung Cancer	CCLE	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation altering degron motif	0.7532
p.G289V	NCI-H1623	lung	COSMIC	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation altering degron motif	0.7532
p.V298L	DO229025	LICA	ICGC	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.2222
p.S661I	DO229027	LICA	ICGC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation altering degron motif	0.7341
p.C677F	DO229031	LICA	ICGC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.1111
p.D300Y	DO229041	LICA	ICGC	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.1667
p.R664H	DO49657	LIHC	ICGC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation altering degron motif	0.8244
p.Q667H	DO23580	LUAD	ICGC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation altering degron motif	0.7582
p.G652W	DO231049	LUSC	ICGC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.0833
p.Y280H	DO35242	PACA	ICGC	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.0833
p.N854I	DO229459	SKCA	ICGC	ASTSS	DEG_SPOP_SBC_1	857:861	Mutation rewiring degron network	0.25
p.S661N	DO37412	SKCM	ICGC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation altering degron motif	0.7069
p.A652V	DO37499	SKCM	ICGC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.0833
p.M283I	DO51294	SKCM	ICGC	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.1667
p.S661G	DO47831	STAD	ICGC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation altering degron motif	0.6993
p.P864L	DO43755	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	857:861	Mutation rewiring degron network	0.25
p.G655R	SIDM00221	Melanoma	GDSC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.1667
p.G655R	ACH-000339	Lung Cancer	CCLE	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.1667
p.P850S	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	857:861	Mutation rewiring degron network	0.1389
p.P850S	NCI-H1435	lung	COSMIC	ASTSS	DEG_SPOP_SBC_1	857:861	Mutation rewiring degron network	0.1389
p.P658S	SIDM01611	Endometrial Carcinoma	GDSC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.25
p.Q852H	ACH-000672	Lung Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	857:861	Mutation rewiring degron network	0.1944
p.Q852H	IA-LM	lung	COSMIC	ASTSS	DEG_SPOP_SBC_1	857:861	Mutation rewiring degron network	0.1944
p.E303K	ACH-000826	Lung Cancer	CCLE	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.0833
p.E303K	CAL-12T	lung	COSMIC	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.0833
p.G302D	ACH-000961	Endometrial/Uterine Cancer	CCLE	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.1111
p.E303G	ACH-000991	Colon/Colorectal Cancer	CCLE	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.0833
p.E303G	SNU-81	large intestine	COSMIC	VTPLSS	DEG_SCF_FBW7_1	289:294	Mutation rewiring degron network	0.0833
p.A670S	ACH-001627	Prostate Cancer	CCLE	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.3056
p.C658F	EBC-1	lung	COSMIC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.25
p.R654Q	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.1389
p.Q847L	201T	lung	COSMIC	ASTSS	DEG_SPOP_SBC_1	857:861	Mutation rewiring degron network	0.0556
p.Q847H	201T	lung	COSMIC	ASTSS	DEG_SPOP_SBC_1	857:861	Mutation rewiring degron network	0.0556
p.D864N	NCI-H1563	lung	COSMIC	ASTSS	DEG_SPOP_SBC_1	857:861	Mutation rewiring degron network	0.25
p.E656Q	MDA-MB-330	breast	COSMIC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.1944
p.N678H	JHU-029	upper aerodigestive tract	COSMIC	TFSSCVPDP	DEG_COP1_1	661:669	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LTBP1

UniProt ID: Q14766

Entrez ID: 4052

Protein name: Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for LTBP1 in