DegronMD

Uniprot ID: Q14766

Source protein: Latent-transforming growth factor beta-binding protein 1

Source gene: LTBP1

Class: DEG_COP1_1

Location: 661:669

E3 ligase: COP1

DEGRON score: 0.5437

ASA_SCORE: 78.6778

COIL: 0.7359

CONS_SCORE: 0.8385

DSS_SCORE: 0.2946

HELIX: 0.0094

FCONS_SCORE: 0.9212

RIG_SCORE: 0.7454

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F656L	TCGA-55-8208	LUAD	TCGA	TFSSCVPDP	DEG_COP1_1	0.1944
p.P667S	TCGA-AJ-A3EL	UCEC	TCGA	TFSSCVPDP	DEG_COP1_1	0.6752
p.P667S	TCGA-AP-A1DV	UCEC	TCGA	TFSSCVPDP	DEG_COP1_1	0.6752
p.P667S	TCGA-AZ-4315	COAD	TCGA	TFSSCVPDP	DEG_COP1_1	0.6752
p.P667S	TCGA-B5-A0JY	UCEC	TCGA	TFSSCVPDP	DEG_COP1_1	0.6752
p.P667S	TCGA-EI-6917	READ	TCGA	TFSSCVPDP	DEG_COP1_1	0.6752
p.I672V	TCGA-AJ-A3EL	UCEC	TCGA	TFSSCVPDP	DEG_COP1_1	0.25
p.T651A	TCGA-AP-A0LM	UCEC	TCGA	TFSSCVPDP	DEG_COP1_1	0.0556
p.S664G	TCGA-AP-A1DK	UCEC	TCGA	TFSSCVPDP	DEG_COP1_1	0.5882
p.T651I	TCGA-BT-A2LA	BLCA	TCGA	TFSSCVPDP	DEG_COP1_1	0.0556
p.G657E	TCGA-DF-A2KU	UCEC	TCGA	TFSSCVPDP	DEG_COP1_1	0.2222
p.S664I	TCGA-DU-6392	LGG	TCGA	TFSSCVPDP	DEG_COP1_1	0.623
p.G655E	TCGA-EE-A3AG	SKCM	TCGA	TFSSCVPDP	DEG_COP1_1	0.1667
p.G655E	TCGA-FS-A1ZA	SKCM	TCGA	TFSSCVPDP	DEG_COP1_1	0.1667
p.E674K	TCGA-EO-A22R	UCEC	TCGA	TFSSCVPDP	DEG_COP1_1	0.1944
p.E674K	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	TFSSCVPDP	DEG_COP1_1	0.1944
p.E674K	NCI-H2009	lung	COSMIC	TFSSCVPDP	DEG_COP1_1	0.1944
p.R670G	DO2545	BRCA	ICGC	TFSSCVPDP	DEG_COP1_1	0.3056
p.G662V	DO50090	COAD	ICGC	TFSSCVPDP	DEG_COP1_1	0.7532
p.R664L	DO234393	ESAD	ICGC	TFSSCVPDP	DEG_COP1_1	0.8428
p.R664P	DO14862	HNSC	ICGC	TFSSCVPDP	DEG_COP1_1	0.7512
p.S661I	DO229027	LICA	ICGC	TFSSCVPDP	DEG_COP1_1	0.7341
p.C677F	DO229031	LICA	ICGC	TFSSCVPDP	DEG_COP1_1	0.1111
p.R664H	DO49657	LIHC	ICGC	TFSSCVPDP	DEG_COP1_1	0.8244
p.Q667H	DO23580	LUAD	ICGC	TFSSCVPDP	DEG_COP1_1	0.7582
p.G652W	DO231049	LUSC	ICGC	TFSSCVPDP	DEG_COP1_1	0.0833
p.S661N	DO37412	SKCM	ICGC	TFSSCVPDP	DEG_COP1_1	0.7069
p.A652V	DO37499	SKCM	ICGC	TFSSCVPDP	DEG_COP1_1	0.0833
p.S661G	DO47831	STAD	ICGC	TFSSCVPDP	DEG_COP1_1	0.6993
p.G655R	SIDM00221	Melanoma	GDSC	TFSSCVPDP	DEG_COP1_1	0.1667
p.G655R	ACH-000339	Lung Cancer	CCLE	TFSSCVPDP	DEG_COP1_1	0.1667
p.P658S	SIDM01611	Endometrial Carcinoma	GDSC	TFSSCVPDP	DEG_COP1_1	0.25
p.A670S	ACH-001627	Prostate Cancer	CCLE	TFSSCVPDP	DEG_COP1_1	0.3056
p.C658F	EBC-1	lung	COSMIC	TFSSCVPDP	DEG_COP1_1	0.25
p.R654Q	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	TFSSCVPDP	DEG_COP1_1	0.1389
p.E656Q	MDA-MB-330	breast	COSMIC	TFSSCVPDP	DEG_COP1_1	0.1944
p.N678H	JHU-029	upper_aerodigestive_tract	COSMIC	TFSSCVPDP	DEG_COP1_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TFSSCVPDP

Degron related mutations and impact score

Drug responses associated with LTBP1 mutations

All proteins holding degron of TFSSCVPDP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14766	Latent-transforming growth factor beta-binding protein 1	DEG_COP1_1	661:669	TFSSCVPDP	COP1	0.5437	More...