DegronMD

Uniprot ID: Q14766

Source protein: Latent-transforming growth factor beta-binding protein 1

Source gene: LTBP1

Class: DEG_SCF_FBW7_1

Location: 289:294

E3 ligase: FBXW7

DEGRON score: 0.9212

ASA_SCORE: 80.0833

COIL: 0.7738

CONS_SCORE: 0.4541

DSS_SCORE: 0.4238

HELIX: 0.0595

FCONS_SCORE: 0.9861

RIG_SCORE: 0.6904

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L292V	TCGA-4Z-AA7O	BLCA	TCGA	VTPLSS	DEG_SCF_FBW7_1	0.5654
p.L292V	DO51865	BLCA	ICGC	VTPLSS	DEG_SCF_FBW7_1	0.5654
p.Q283H	TCGA-A5-A0G1	UCEC	TCGA	VTPLSS	DEG_SCF_FBW7_1	0.1667
p.Q283H	DO42472	UCEC	ICGC	VTPLSS	DEG_SCF_FBW7_1	0.1667
p.H301L	TCGA-QC-A7B5	SARC	TCGA	VTPLSS	DEG_SCF_FBW7_1	0.1389
p.H301L	DO220239	SARC	ICGC	VTPLSS	DEG_SCF_FBW7_1	0.1389
p.S294F	TCGA-WE-A8K5	SKCM	TCGA	VTPLSS	DEG_SCF_FBW7_1	0.7982
p.S294F	DO51282	SKCM	ICGC	VTPLSS	DEG_SCF_FBW7_1	0.7982
p.N295T	DO234350	ESAD	ICGC	VTPLSS	DEG_SCF_FBW7_1	0.3056
p.G289V	DO228985	LICA	ICGC	VTPLSS	DEG_SCF_FBW7_1	0.7532
p.G289V	ACH-000744	Lung Cancer	CCLE	VTPLSS	DEG_SCF_FBW7_1	0.7532
p.G289V	NCI-H1623	lung	COSMIC	VTPLSS	DEG_SCF_FBW7_1	0.7532
p.V298L	DO229025	LICA	ICGC	VTPLSS	DEG_SCF_FBW7_1	0.2222
p.D300Y	DO229041	LICA	ICGC	VTPLSS	DEG_SCF_FBW7_1	0.1667
p.Y280H	DO35242	PACA	ICGC	VTPLSS	DEG_SCF_FBW7_1	0.0833
p.M283I	DO51294	SKCM	ICGC	VTPLSS	DEG_SCF_FBW7_1	0.1667
p.E303K	ACH-000826	Lung Cancer	CCLE	VTPLSS	DEG_SCF_FBW7_1	0.0833
p.E303K	CAL-12T	lung	COSMIC	VTPLSS	DEG_SCF_FBW7_1	0.0833
p.G302D	ACH-000961	Endometrial/Uterine Cancer	CCLE	VTPLSS	DEG_SCF_FBW7_1	0.1111
p.E303G	ACH-000991	Colon/Colorectal Cancer	CCLE	VTPLSS	DEG_SCF_FBW7_1	0.0833
p.E303G	SNU-81	large_intestine	COSMIC	VTPLSS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14766	Latent-transforming growth factor beta-binding protein 1	DEG_SCF_FBW7_1	289:294	VTPLSS	FBXW7	0.9212	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons