DegronMD - Q96RS0(TGS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H541R	TCGA-3K-AAZ8	LIHC	TCGA	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.2778
p.H541R	DO219543	LIHC	ICGC	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.2778
p.S51G	TCGA-77-8128	LUSC	TCGA	DSGNNS	DEG_SCF_TRCP1_1	50:55	Mutation altering degron motif	0.8104
p.S51G	DO26464	LUSC	ICGC	DSGNNS	DEG_SCF_TRCP1_1	50:55	Mutation altering degron motif	0.8104
p.S536F	TCGA-B5-A3FC	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1389
p.S536F	DO41871	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1389
p.S536F	SIDM01611	Endometrial Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1389
p.S536F	ACH-000996	Endometrial/Uterine Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1389
p.E63Q	TCGA-CV-6441	HNSC	TCGA	DSGNNS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.1111
p.E63Q	DO14254	HNSC	ICGC	DSGNNS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.1111
p.H537R	TCGA-F7-A624	HNSC	TCGA	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1667
p.H537R	DO44440	HNSC	ICGC	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1667
p.A543T	TCGA-H4-A2HO	BLCA	TCGA	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation altering degron motif	0.7139
p.A543T	DO494	BLCA	ICGC	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation altering degron motif	0.7139
p.D57N	TCGA-XF-AAMX	BLCA	TCGA	DSGNNS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.2778
p.D57N	DO51939	BLCA	ICGC	DSGNNS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.2778
p.G45S	DO233189	GACA	ICGC	DSGNNS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.1944
p.M554I	DO228985	LICA	ICGC	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1389
p.V540L	DO229045	LICA	ICGC	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.25
p.G65D	DO23517	LIRI	ICGC	DSGNNS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.0556
p.D542G	DO228338	MALY	ICGC	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.3056
p.I48M	DO51954	PRAD	ICGC	DSGNNS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.2778
p.D538G	SIDM00586	Hepatocellular Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1944
p.D538G	ACH-000475	Liver Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1944
p.D538G	huH-1	liver	COSMIC	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1944
p.Q58H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGNNS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.25
p.Q58H	ACH-000981	Leukemia	CCLE	DSGNNS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.25
p.Q58H	DND-41	haematopoietic and lymphoid tissue	COSMIC	DSGNNS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.25
p.S546I	SIDM00789	Colorectal Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation altering degron motif	0.7341
p.S546I	ACH-000997	Colon/Colorectal Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation altering degron motif	0.7341
p.S546I	ACH-001061	Colon/Colorectal Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation altering degron motif	0.7341
p.S546I	ACH-001091	Colon/Colorectal Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation altering degron motif	0.7341
p.S546I	HCT-15	large intestine	COSMIC	ASTSS	DEG_SPOP_SBC_1	543:547	Mutation altering degron motif	0.7341
p.G42V	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	DSGNNS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.1111
p.G42V	ACH-000781	Lung Cancer	CCLE	DSGNNS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.1111
p.G42V	NCI-H2023	lung	COSMIC	DSGNNS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.1111
p.L41V	SIDM00011	Melanoma	GDSC	DSGNNS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.0833
p.L41V	ACH-000477	Skin Cancer	CCLE	DSGNNS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.0833

Kaplan plot for TGS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TGS1

UniProt ID: Q96RS0

Entrez ID: 96764

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TGS1 in