DegronMD

Uniprot ID: Q96RS0

Source protein: Trimethylguanosine synthase

Source gene: TGS1

Class: DEG_SCF_TRCP1_1

Location: 50:55

E3 ligase: BTRC

DEGRON score: 0.8164

ASA_SCORE: 81.1

COIL: 0.8322

CONS_SCORE: 0.2849

DSS_SCORE: 0.4421

HELIX: 0.0448

FCONS_SCORE: 0.8885

RIG_SCORE: 0.6378

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S51G	TCGA-77-8128	LUSC	TCGA	DSGNNS	DEG_SCF_TRCP1_1	0.8104
p.S51G	DO26464	LUSC	ICGC	DSGNNS	DEG_SCF_TRCP1_1	0.8104
p.E63Q	TCGA-CV-6441	HNSC	TCGA	DSGNNS	DEG_SCF_TRCP1_1	0.1111
p.E63Q	DO14254	HNSC	ICGC	DSGNNS	DEG_SCF_TRCP1_1	0.1111
p.D57N	TCGA-XF-AAMX	BLCA	TCGA	DSGNNS	DEG_SCF_TRCP1_1	0.2778
p.D57N	DO51939	BLCA	ICGC	DSGNNS	DEG_SCF_TRCP1_1	0.2778
p.G45S	DO233189	GACA	ICGC	DSGNNS	DEG_SCF_TRCP1_1	0.1944
p.G65D	DO23517	LIRI	ICGC	DSGNNS	DEG_SCF_TRCP1_1	0.0556
p.I48M	DO51954	PRAD	ICGC	DSGNNS	DEG_SCF_TRCP1_1	0.2778
p.Q58H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGNNS	DEG_SCF_TRCP1_1	0.25
p.Q58H	ACH-000981	Leukemia	CCLE	DSGNNS	DEG_SCF_TRCP1_1	0.25
p.Q58H	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	DSGNNS	DEG_SCF_TRCP1_1	0.25
p.G42V	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	DSGNNS	DEG_SCF_TRCP1_1	0.1111
p.G42V	ACH-000781	Lung Cancer	CCLE	DSGNNS	DEG_SCF_TRCP1_1	0.1111
p.G42V	NCI-H2023	lung	COSMIC	DSGNNS	DEG_SCF_TRCP1_1	0.1111
p.L41V	SIDM00011	Melanoma	GDSC	DSGNNS	DEG_SCF_TRCP1_1	0.0833
p.L41V	ACH-000477	Skin Cancer	CCLE	DSGNNS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RS0	Trimethylguanosine synthase	DEG_SCF_TRCP1_1	50:55	DSGNNS	BTRC	0.8164	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons