DegronMD

Uniprot ID: Q86UP3

Source protein: Zinc finger homeobox protein 4

Source gene: ZFHX4

Class: DEG_SPOP_SBC_1

Location: 386:390

E3 ligase: SPOP

DEGRON score: 0.9577

ASA_SCORE: 70.56

COIL: 0.8538

CONS_SCORE: 0.3472

DSS_SCORE: 0.3673

HELIX: 0.116

FCONS_SCORE: 0.9884

RIG_SCORE: 0.6313

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A386T	TCGA-34-5928	LUSC	TCGA	ASTSS	DEG_SPOP_SBC_1	0.7139
p.A386T	TCGA-WS-AB45	COAD	TCGA	ASTSS	DEG_SPOP_SBC_1	0.7139
p.A386T	DO51734	COAD	ICGC	ASTSS	DEG_SPOP_SBC_1	0.7139
p.A386T	DO27461	LUSC	ICGC	ASTSS	DEG_SPOP_SBC_1	0.7139
p.T388S	TCGA-44-2662	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	0.6005
p.T388S	DO26290	LUAD	ICGC	ASTSS	DEG_SPOP_SBC_1	0.6005
p.A386V	TCGA-55-8097	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	0.5825
p.A386V	DO230311	COCA	ICGC	ASTSS	DEG_SPOP_SBC_1	0.5825
p.A386V	DO25699	LUAD	ICGC	ASTSS	DEG_SPOP_SBC_1	0.5825
p.S387C	TCGA-55-8302	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	0.643
p.S387C	DO45312	LUAD	ICGC	ASTSS	DEG_SPOP_SBC_1	0.643
p.S389L	TCGA-5M-AAT6	COAD	TCGA	ASTSS	DEG_SPOP_SBC_1	0.7667
p.S389L	DO223703	COAD	ICGC	ASTSS	DEG_SPOP_SBC_1	0.7667
p.G378V	TCGA-67-3771	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	0.1111
p.G378V	DO25797	LUAD	ICGC	ASTSS	DEG_SPOP_SBC_1	0.1111
p.K383T	TCGA-BK-A6W3	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	0.3611
p.K383T	DO50076	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	0.3611
p.A392T	TCGA-E6-A1LX	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	0.2778
p.A392T	DO41020	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	0.2778
p.G397E	TCGA-EE-A2M5	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	0.1389
p.G397E	DO222423	MELA	ICGC	ASTSS	DEG_SPOP_SBC_1	0.1389
p.G397E	DO222753	MELA	ICGC	ASTSS	DEG_SPOP_SBC_1	0.1389
p.G397E	DO37425	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	0.1389
p.G384R	TCGA-FS-A4F0	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	0.2778
p.G384R	TCGA-FW-A3R5	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	0.2778
p.G384R	TCGA-YG-AA3N	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	0.2778
p.G384R	DO37891	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	0.2778
p.G384R	DO37406	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	0.2778
p.G384R	DO51298	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	0.2778
p.P376L	DO225132	BRCA	ICGC	ASTSS	DEG_SPOP_SBC_1	0.0556
p.P376L	DO27893	ORCA	ICGC	ASTSS	DEG_SPOP_SBC_1	0.0556
p.S387I	DO229031	LICA	ICGC	ASTSS	DEG_SPOP_SBC_1	0.623
p.G384E	DO220889	MELA	ICGC	ASTSS	DEG_SPOP_SBC_1	0.2778
p.P376Q	SIDM00845	Burkitt's Lymphoma	GDSC	ASTSS	DEG_SPOP_SBC_1	0.0556
p.P376Q	SIDM00461	Acute Myeloid Leukemia	GDSC	ASTSS	DEG_SPOP_SBC_1	0.0556
p.P376Q	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ASTSS	DEG_SPOP_SBC_1	0.0556
p.P376Q	SIDM01519	Head and Neck Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	0.0556
p.P376Q	ACH-000786	Lymphoma	CCLE	ASTSS	DEG_SPOP_SBC_1	0.0556
p.P376Q	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ASTSS	DEG_SPOP_SBC_1	0.0556
p.Q400H	SIDM00845	Burkitt's Lymphoma	GDSC	ASTSS	DEG_SPOP_SBC_1	0.0556
p.Q400H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ASTSS	DEG_SPOP_SBC_1	0.0556
p.Q400H	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ASTSS	DEG_SPOP_SBC_1	0.0556
p.A377T	SIDM00192	Colorectal Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	0.0833
p.A392V	SIDM01412	Oral Cavity Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	0.2778
p.A392V	ACH-000762	Head and Neck Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MYU2	Potassium channel subfamily U member 1	DEG_SPOP_SBC_1	659:663	ASTSS	SPOP	0.9898	More...
P43243	Matrin-3	DEG_SPOP_SBC_1	76:80	ASTSS	SPOP	0.9927	More...
P51965	Ubiquitin-conjugating enzyme E2 E1	DEG_SPOP_SBC_1	8:12	ASTSS	SPOP	0.9054	More...
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	549:553	ASTSS	SPOP	0.9989	More...
Q14766	Latent-transforming growth factor beta-binding protein 1	DEG_SPOP_SBC_1	857:861	ASTSS	SPOP	0.8183	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1426:1430	ASTSS	SPOP	0.9825	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1588:1592	ASTSS	SPOP	0.8933	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	548:552	ASTSS	SPOP	0.9698	More...
Q5HYW2	NHS-like protein 2	DEG_SPOP_SBC_1	527:531	ASTSS	SPOP	0.9546	More...
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_SPOP_SBC_1	804:808	ASTSS	SPOP	0.9808	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	1759:1763	ASTSS	SPOP	0.9982	More...
Q5VV67	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1	DEG_SPOP_SBC_1	615:619	ASTSS	SPOP	0.9821	More...
Q86SQ0	Pleckstrin homology-like domain family B member 2	DEG_SPOP_SBC_1	344:348	ASTSS	SPOP	0.997	More...
Q86UK7	E3 ubiquitin-protein ligase ZNF598	DEG_SPOP_SBC_1	450:454	ASTSS	SPOP	0.9877	More...
Q86UP3	Zinc finger homeobox protein 4	DEG_SPOP_SBC_1	386:390	ASTSS	SPOP	0.9577	More...
Q86UP3	Zinc finger homeobox protein 4	DEG_SPOP_SBC_1	2387:2391	ASTSS	SPOP	0.9738	More...
Q86X51	EZH inhibitory protein	DEG_SPOP_SBC_1	189:193	ASTSS	SPOP	0.9261	More...
Q8IYT8	Serine/threonine-protein kinase ULK2	DEG_SPOP_SBC_1	339:343	ASTSS	SPOP	0.9908	More...
Q93052	Lipoma-preferred partner	DEG_SPOP_SBC_1	213:217	ASTSS	SPOP	0.9931	More...
Q96RS0	Trimethylguanosine synthase	DEG_SPOP_SBC_1	543:547	ASTSS	SPOP	0.8361	More...
Q99569	Plakophilin-4	DEG_SPOP_SBC_1	79:83	ASTSS	SPOP	0.855	More...
Q9BX26	Synaptonemal complex protein 2	DEG_SPOP_SBC_1	632:636	ASTSS	SPOP	0.7586	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	1710:1714	ASTSS	SPOP	0.9886	More...
Q9NXE8	Pre-mRNA-splicing factor CWC25 homolog	DEG_SPOP_SBC_1	395:399	ASTSS	SPOP	0.9445	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	1536:1540	ASTSS	SPOP	0.9582	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	2020:2024	ASTSS	SPOP	0.9147	More...
Q9UMD9	Collagen alpha-1	DEG_SPOP_SBC_1	75:79	ASTSS	SPOP	0.9856	More...
Q9Y6X2	E3 SUMO-protein ligase PIAS3	DEG_SPOP_SBC_1	148:152	ASTSS	SPOP	0.911	More...
Q9Y6Y8	SEC23-interacting protein	DEG_SPOP_SBC_1	13:17	ASTSS	SPOP	0.8563	More...
P0C7U0	Protein ELFN1	DEG_SPOP_SBC_1	638:642	ASTSS	SPOP	0.9866	More...
Q2NL68	Proline and serine-rich protein 3	DEG_SPOP_SBC_1	224:228	ASTSS	SPOP	0.9076	More...
Q7Z3E2	Coiled-coil domain-containing protein 186	DEG_SPOP_SBC_1	8:12	ASTSS	SPOP	0.8056	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	378:382	ASTSS	SPOP	0.9794	More...
P0CG42	Putative protein FAM157B	DEG_SPOP_SBC_1	345:349	ASTSS	SPOP	0.9752	More...
P0CG43	Putative protein FAM157C	DEG_SPOP_SBC_1	348:352	ASTSS	SPOP	0.9203	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASTSS

Degron related mutations and impact score

Drug responses associated with ZFHX4 mutations

All proteins holding degron of ASTSS