DegronMD - Q9NXE8(CWC25)

CWC25

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R389H	TCGA-17-Z007	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1667
p.R389H	TCGA-38-6178	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1667
p.R389H	TCGA-AX-A06F	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1667
p.R389H	TCGA-EY-A1G8	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1667
p.R406Q	TCGA-AZ-6601	COAD	TCGA	ASTSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1389
p.L392P	TCGA-CN-A63U	HNSC	TCGA	ASTSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.25
p.S399F	TCGA-EA-A5ZF	CESC	TCGA	ASTSS	DEG_SPOP_SBC_1	395:399	Mutation altering degron motif	0.9093
p.L400M	SIDM00522	Small Cell Lung Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.3056
p.L400M	SIDM00767	Small Cell Lung Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.3056
p.L400M	SIDM01624	Bladder Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.3056
p.L400M	SIDM01529	Bladder Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.3056
p.Y409C	SIDM00516	Melanoma	GDSC	ASTSS	DEG_SPOP_SBC_1	395:399	Mutation blocking phosphorylation signal	0.5
p.Y409C	ACH-002166	Skin Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	395:399	Mutation blocking phosphorylation signal	0.5

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*NOTE: the Kaplan plots were collected from OncoLnc