DegronMD

Uniprot ID: Q86UP3

Source protein: Zinc finger homeobox protein 4

Source gene: ZFHX4

Class: DEG_SCF_FBW7_1

Location: 415:422

E3 ligase: FBXW7

DEGRON score: 0.9831

ASA_SCORE: 80.35

COIL: 0.8361

CONS_SCORE: 0.3715

DSS_SCORE: 0.388

HELIX: 0.0481

FCONS_SCORE: 1.0388

RIG_SCORE: 0.7466

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G409W	TCGA-55-7573	LUAD	TCGA	VVNTPITS	DEG_SCF_FBW7_1	0.1667
p.G409W	DO23675	LUAD	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.1667
p.S432Y	TCGA-73-4668	LUAD	TCGA	VVNTPITS	DEG_SCF_FBW7_1	0.0556
p.S432Y	DO23961	LUAD	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.0556
p.L408M	TCGA-B5-A3FA	UCEC	TCGA	VVNTPITS	DEG_SCF_FBW7_1	0.1389
p.L408M	DO52402	UCEC	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.1389
p.S428P	TCGA-BR-4257	STAD	TCGA	VVNTPITS	DEG_SCF_FBW7_1	0.1667
p.S428P	DO38683	STAD	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.1667
p.V423I	TCGA-D1-A2G0	UCEC	TCGA	VVNTPITS	DEG_SCF_FBW7_1	0.3056
p.V423I	DO43049	UCEC	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.3056
p.S426G	TCGA-FI-A2D5	UCEC	TCGA	VVNTPITS	DEG_SCF_FBW7_1	0.2222
p.S426G	DO41331	UCEC	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.2222
p.G410W	TCGA-NJ-A4YF	LUAD	TCGA	VVNTPITS	DEG_SCF_FBW7_1	0.1944
p.G410W	DO218940	LUAD	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.1944
p.S422F	TCGA-NK-A5CT	LUSC	TCGA	VVNTPITS	DEG_SCF_FBW7_1	0.7982
p.S422F	DO219209	LUSC	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.7982
p.S424F	TCGA-YG-AA3O	SKCM	TCGA	VVNTPITS	DEG_SCF_FBW7_1	0.2778
p.S424F	DO51299	SKCM	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.2778
p.I420V	DO52617	BOCA	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.5965
p.H427N	DO233189	GACA	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.1944
p.S426R	DO233189	GACA	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.2222
p.S429L	SIDM00545	Melanoma	GDSC	VVNTPITS	DEG_SCF_FBW7_1	0.1389
p.S429L	ACH-000987	Skin Cancer	CCLE	VVNTPITS	DEG_SCF_FBW7_1	0.1389
p.S429L	Mewo	skin	COSMIC	VVNTPITS	DEG_SCF_FBW7_1	0.1389
p.S428L	SIDM00845	Burkitt's Lymphoma	GDSC	VVNTPITS	DEG_SCF_FBW7_1	0.1667
p.S428L	SIDM00461	Acute Myeloid Leukemia	GDSC	VVNTPITS	DEG_SCF_FBW7_1	0.1667
p.S428L	SIDM01519	Head and Neck Carcinoma	GDSC	VVNTPITS	DEG_SCF_FBW7_1	0.1667
p.S428L	ACH-000786	Lymphoma	CCLE	VVNTPITS	DEG_SCF_FBW7_1	0.1667
p.S428L	ACH-000992	Head and Neck Cancer	CCLE	VVNTPITS	DEG_SCF_FBW7_1	0.1667
p.S428L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VVNTPITS	DEG_SCF_FBW7_1	0.1667
p.V416L	SIDM00660	Colorectal Carcinoma	GDSC	VVNTPITS	DEG_SCF_FBW7_1	0.5654
p.V416L	ACH-000985	Colon/Colorectal Cancer	CCLE	VVNTPITS	DEG_SCF_FBW7_1	0.5654
p.V416L	LS-411N	large_intestine	COSMIC	VVNTPITS	DEG_SCF_FBW7_1	0.5654
p.P419L	SIDM00097	Breast Carcinoma	GDSC	VVNTPITS	DEG_SCF_FBW7_1	0.7582
p.P419L	ACH-000147	Breast Cancer	CCLE	VVNTPITS	DEG_SCF_FBW7_1	0.7582
p.P419L	T47D	breast	COSMIC	VVNTPITS	DEG_SCF_FBW7_1	0.7582
p.G410V	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	VVNTPITS	DEG_SCF_FBW7_1	0.1944
p.G410V	ACH-000845	Lung Cancer	CCLE	VVNTPITS	DEG_SCF_FBW7_1	0.1944
p.H427Y	ACH-001148	Lymphoma	CCLE	VVNTPITS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVNTPITS

Degron related mutations and impact score

Drug responses associated with ZFHX4 mutations

All proteins holding degron of VVNTPITS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UP3	Zinc finger homeobox protein 4	DEG_SCF_FBW7_1	415:422	VVNTPITS	FBXW7	0.9831	More...