DegronMD

Uniprot ID: Q86UP3

Source protein: Zinc finger homeobox protein 4

Source gene: ZFHX4

Class: DEG_SCF_FBW7_1

Location: 415:422

E3 ligase: FBXW7

DEGRON score: 0.9831

ASA_SCORE: 80.35

COIL: 0.8361

CONS_SCORE: 0.3715

DSS_SCORE: 0.388

HELIX: 0.0481

FCONS_SCORE: 1.0388

RIG_SCORE: 0.7466

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S422F	TCGA-NK-A5CT	LUSC	TCGA	VVNTPITS	DEG_SCF_FBW7_1	0.7982
p.S422F	DO219209	LUSC	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.7982
p.P419L	SIDM00097	Breast Carcinoma	GDSC	VVNTPITS	DEG_SCF_FBW7_1	0.7582
p.P419L	ACH-000147	Breast Cancer	CCLE	VVNTPITS	DEG_SCF_FBW7_1	0.7582
p.P419L	T47D	breast	COSMIC	VVNTPITS	DEG_SCF_FBW7_1	0.7582
p.I420V	DO52617	BOCA	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.5965
p.V416L	SIDM00660	Colorectal Carcinoma	GDSC	VVNTPITS	DEG_SCF_FBW7_1	0.5654
p.V416L	ACH-000985	Colon/Colorectal Cancer	CCLE	VVNTPITS	DEG_SCF_FBW7_1	0.5654
p.V416L	LS-411N	large_intestine	COSMIC	VVNTPITS	DEG_SCF_FBW7_1	0.5654
p.V423I	TCGA-D1-A2G0	UCEC	TCGA	VVNTPITS	DEG_SCF_FBW7_1	0.3056
p.V423I	DO43049	UCEC	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.3056
p.S424F	TCGA-YG-AA3O	SKCM	TCGA	VVNTPITS	DEG_SCF_FBW7_1	0.2778
p.S424F	DO51299	SKCM	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.2778
p.S426G	TCGA-FI-A2D5	UCEC	TCGA	VVNTPITS	DEG_SCF_FBW7_1	0.2222
p.S426G	DO41331	UCEC	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.2222
p.S426R	DO233189	GACA	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.2222
p.G410W	TCGA-NJ-A4YF	LUAD	TCGA	VVNTPITS	DEG_SCF_FBW7_1	0.1944
p.G410W	DO218940	LUAD	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.1944
p.H427N	DO233189	GACA	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.1944
p.G410V	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	VVNTPITS	DEG_SCF_FBW7_1	0.1944
p.G410V	ACH-000845	Lung Cancer	CCLE	VVNTPITS	DEG_SCF_FBW7_1	0.1944
p.H427Y	ACH-001148	Lymphoma	CCLE	VVNTPITS	DEG_SCF_FBW7_1	0.1944
p.G409W	TCGA-55-7573	LUAD	TCGA	VVNTPITS	DEG_SCF_FBW7_1	0.1667
p.G409W	DO23675	LUAD	ICGC	VVNTPITS	DEG_SCF_FBW7_1	0.1667
p.S428P	TCGA-BR-4257	STAD	TCGA	VVNTPITS	DEG_SCF_FBW7_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UP3	Zinc finger homeobox protein 4	DEG_SCF_FBW7_1	415:422	VVNTPITS	FBXW7	0.9831	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons