DegronMD

Uniprot ID: Q86UP3

Source protein: Zinc finger homeobox protein 4

Source gene: ZFHX4

Class: DEG_ODPH_VHL_1

Location: 1061:1074

E3 ligase: VHL

DEGRON score: 0.6393

ASA_SCORE: 78.05

COIL: 0.6611

CONS_SCORE: 0.381

DSS_SCORE: 0.4102

HELIX: 0.0879

FCONS_SCORE: 0.9929

RIG_SCORE: 0.7665

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1073H	TCGA-2F-A9KO	BLCA	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7582
p.R1067L	TCGA-33-4538	LUSC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.8428
p.L1062Q	TCGA-44-2657	LUAD	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7765
p.H1065N	TCGA-56-6546	LUSC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7423
p.V1063E	TCGA-77-8140	LUSC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7693
p.C1052R	TCGA-A5-A0G2	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.0833
p.G1076V	TCGA-A5-A0G2	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.2778
p.S1068L	TCGA-A5-A2K5	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7667
p.S1068L	TCGA-AG-A002	READ	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7667
p.S1068L	TCGA-AP-A056	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7667
p.S1068L	TCGA-BS-A0UF	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7667
p.S1068L	TCGA-EO-A22U	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7667
p.S1068L	TCGA-EO-A22X	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7667
p.S1068L	TCGA-FI-A2D0	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7667
p.S1068L	ACH-001567	Skin Cancer	CCLE	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7667
p.V1058F	TCGA-AA-3875	COAD	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.25
p.L1062M	TCGA-B5-A1MR	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.711
p.L1062M	TCGA-E6-A1LX	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.711
p.R1078W	TCGA-B5-A1MR	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.2222
p.R1078W	SIDM00917	Acute Myeloid Leukemia	GDSC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.2222
p.R1078W	ACH-002218	Leukemia	CCLE	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.2222
p.R1078W	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.2222
p.R1078Q	TCGA-BF-A5EO	SKCM	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.2222
p.R1078Q	TCGA-GF-A6C9	SKCM	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.2222
p.L1060F	TCGA-CF-A47X	BLCA	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.3056
p.T1056A	TCGA-CG-5717	STAD	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.1944
p.T1055S	TCGA-D1-A17F	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.1667
p.K1070N	TCGA-FI-A2D5	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.6918
p.T1055I	TCGA-FR-A3YN	SKCM	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.1667
p.K1070T	TCGA-IG-A4QS	ESCA	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7306
p.Q1084K	TCGA-J2-8194	LUAD	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.0556
p.Q1084K	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.0556
p.Q1084K	ACH-000481	Lung Cancer	CCLE	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.0556
p.Q1084K	NCI-H2170	lung	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.0556
p.Q1081K	TCGA-NJ-A55R	LUAD	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.1389
p.R1067S	TCGA-PG-A6IB	UCEC	TCGA	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7427
p.E1064G	DO10590	COAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.6087
p.Q1055R	DO234245	ESAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.1667
p.D1076V	DO24527	LUAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.2778
p.Q1055K	DO218947	LUAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.1667
p.I1071N	DO25426	LUAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.6169
p.I1071N	DO38352	STAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.6169
p.Q1058K	DO23971	LUAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.25
p.Q1058K	NCI-H2170	lung	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.25
p.N1080I	DO23557	LUAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.1667
p.P1063L	DO26522	LUSC	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7582
p.A1062T	DO219133	LUSC	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7139
p.A1062T	DO46957	RECA	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7139
p.N1067S	DO222395	MELA	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.5958
p.Q1055H	DO51965	PRAD	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.1667
p.L1068F	DO47590	SKCM	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.587
p.R1052Q	DO51254	SKCM	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.0833
p.R1052Q	DO219450	SKCM	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.0833
p.F1072L	DO42033	UCEC	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.587
p.R1052W	DO41758	UCEC	ICGC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.0833
p.R1052W	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.0833
p.Q1064L	SIDM01118	Small Cell Lung Carcinoma	GDSC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7765
p.Q1064L	ACH-002175	Lung Cancer	CCLE	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7765
p.Q1064L	NCI-H740	lung	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7765
p.K1059N	SIDM00531	Pancreatic Carcinoma	GDSC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.2778
p.K1059N	ACH-000213	Pancreatic Cancer	CCLE	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.2778
p.K1059N	HuP-T4	pancreas	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.2778
p.K1059E	ACH-000961	Endometrial/Uterine Cancer	CCLE	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.2778
p.H1071L	ACH-002027	Endometrial/Uterine Cancer	CCLE	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.7313
p.L1082F	5637	urinary_tract	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.1111
p.G1060D	U-118-MG	central_nervous_system	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.3056
p.P1078S	KALS-1	central_nervous_system	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.2222
p.L1062V	LN-229	central_nervous_system	COSMIC	LAPEEDNLSEIFFV	DEG_ODPH_VHL_1	0.6765

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPEEDNLSEIFFV

Degron related mutations and impact score

Drug responses associated with ZFHX4 mutations

All proteins holding degron of LAPEEDNLSEIFFV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UP3	Zinc finger homeobox protein 4	DEG_ODPH_VHL_1	1061:1074	LAPEEDNLSEIFFV	VHL	0.6393	More...