DegronMD

Uniprot ID: Q15911

Source protein: Zinc finger homeobox protein 3

Source gene: ZFHX3

Class: DEG_SCF_FBW7_1

Location: 3135:3142

E3 ligase: FBXW7

DEGRON score: 0.7728

ASA_SCORE: 73.575

COIL: 0.8664

CONS_SCORE: 0.3248

DSS_SCORE: 0.5476

HELIX: 0.1053

FCONS_SCORE: 0.9824

RIG_SCORE: 0.6377

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3127L	TCGA-AJ-A3EK	UCEC	TCGA	PGFTPSNT	DEG_SCF_FBW7_1	0.1111
p.P3127L	DO41584	UCEC	ICGC	PGFTPSNT	DEG_SCF_FBW7_1	0.1111
p.P3149L	TCGA-BR-8078	STAD	TCGA	PGFTPSNT	DEG_SCF_FBW7_1	0.1389
p.P3149L	DO38288	STAD	ICGC	PGFTPSNT	DEG_SCF_FBW7_1	0.1389
p.P3139L	TCGA-EE-A20C	SKCM	TCGA	PGFTPSNT	DEG_SCF_FBW7_1	0.7582
p.S3146F	TCGA-L5-A4OI	ESCA	TCGA	PGFTPSNT	DEG_SCF_FBW7_1	0.2222
p.P3127S	WM793B	skin	COSMIC	PGFTPSNT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15911	Zinc finger homeobox protein 3	DEG_SCF_FBW7_1	3135:3142	PGFTPSNT	FBXW7	0.7728	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons