DegronMD

Uniprot ID: Q15911

Source protein: Zinc finger homeobox protein 3

Source gene: ZFHX3

Class: DEG_SCF_FBW7_1

Location: 2604:2610

E3 ligase: FBXW7

DEGRON score: 0.7869

ASA_SCORE: 94.3857

COIL: 0.932

CONS_SCORE: 0.3923

DSS_SCORE: 0.6668

HELIX: 0.062

FCONS_SCORE: 0.9749

RIG_SCORE: 0.5986

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2605L	TCGA-77-7337	LUSC	TCGA	PSTPTST	DEG_SCF_FBW7_1	0.6556
p.S2605L	DO27445	LUSC	ICGC	PSTPTST	DEG_SCF_FBW7_1	0.6556
p.R2616K	TCGA-BQ-5878	KIRP	TCGA	PSTPTST	DEG_SCF_FBW7_1	0.1667
p.Q2595E	TCGA-ZJ-AAXT	CESC	TCGA	PSTPTST	DEG_SCF_FBW7_1	0.0833
p.Q2595E	DO219758	CESC	ICGC	PSTPTST	DEG_SCF_FBW7_1	0.0833
p.G2596S	DO35083	PACA	ICGC	PSTPTST	DEG_SCF_FBW7_1	0.1111
p.G2600A	DO229173	THCA	ICGC	PSTPTST	DEG_SCF_FBW7_1	0.2222
p.A2619V	DO229234	THCA	ICGC	PSTPTST	DEG_SCF_FBW7_1	0.0833
p.G2597C	DO229250	THCA	ICGC	PSTPTST	DEG_SCF_FBW7_1	0.1389
p.T2608S	SIDM01313	Colorectal Carcinoma	GDSC	PSTPTST	DEG_SCF_FBW7_1	0.6005
p.T2608A	SIDM01504	Small Cell Lung Carcinoma	GDSC	PSTPTST	DEG_SCF_FBW7_1	0.6028
p.C2620W	NCI-H2172	lung	COSMIC	PSTPTST	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15911	Zinc finger homeobox protein 3	DEG_SCF_FBW7_1	2604:2610	PSTPTST	FBXW7	0.7869	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons