DegronMD

Uniprot ID: Q15911

Source protein: Zinc finger homeobox protein 3

Source gene: ZFHX3

Class: DEG_SCF_TRCP1_1

Location: 3690:3695

E3 ligase: BTRC

DEGRON score: 0.9068

ASA_SCORE: 56.1667

COIL: 0.7567

CONS_SCORE: 0.2935

DSS_SCORE: 0.6629

HELIX: 0.1223

FCONS_SCORE: 0.9872

RIG_SCORE: 0.6328

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K3683T	TCGA-A5-A1OF	UCEC	TCGA	DSGLTS	DEG_SCF_TRCP1_1	0.25
p.D3684V	TCGA-D3-A5GR	SKCM	TCGA	DSGLTS	DEG_SCF_TRCP1_1	0.1667
p.D3684V	DO47436	SKCM	ICGC	DSGLTS	DEG_SCF_TRCP1_1	0.1667
p.P3688H	TCGA-FD-A5BX	BLCA	TCGA	DSGLTS	DEG_SCF_TRCP1_1	0.2778
p.P3688H	DO44079	BLCA	ICGC	DSGLTS	DEG_SCF_TRCP1_1	0.2778
p.T3694I	TCGA-HU-8602	STAD	TCGA	DSGLTS	DEG_SCF_TRCP1_1	0.5966
p.T3698M	DO222955	BTCA	ICGC	DSGLTS	DEG_SCF_TRCP1_1	0.25
p.D3699G	SIDM00680	Colorectal Carcinoma	GDSC	DSGLTS	DEG_SCF_TRCP1_1	0.2222
p.D3699G	ACH-000957	Colon/Colorectal Cancer	CCLE	DSGLTS	DEG_SCF_TRCP1_1	0.2222
p.D3699G	LS-180	large_intestine	COSMIC	DSGLTS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15911	Zinc finger homeobox protein 3	DEG_SCF_TRCP1_1	3690:3695	DSGLTS	BTRC	0.9068	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons