DegronMD

Uniprot ID: Q15911

Source protein: Zinc finger homeobox protein 3

Source gene: ZFHX3

Class: DEG_SCF_FBW7_1

Location: 410:417

E3 ligase: FBXW7

DEGRON score: 0.8779

ASA_SCORE: 96.425

COIL: 0.9056

CONS_SCORE: 0.3673

DSS_SCORE: 0.397

HELIX: 0.0244

FCONS_SCORE: 1.0102

RIG_SCORE: 0.767

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P419S	TCGA-BF-A5EP	SKCM	TCGA	VLKTPITS	DEG_SCF_FBW7_1	0.2778
p.P419S	DO223906	SKCM	ICGC	VLKTPITS	DEG_SCF_FBW7_1	0.2778
p.A424D	TCGA-DU-6392	LGG	TCGA	VLKTPITS	DEG_SCF_FBW7_1	0.1389
p.A424D	DO22237	LGG	ICGC	VLKTPITS	DEG_SCF_FBW7_1	0.1389
p.P419L	TCGA-EE-A2GS	SKCM	TCGA	VLKTPITS	DEG_SCF_FBW7_1	0.2778
p.P419L	DO37465	SKCM	ICGC	VLKTPITS	DEG_SCF_FBW7_1	0.2778
p.S417L	TCGA-EK-A3GK	CESC	TCGA	VLKTPITS	DEG_SCF_FBW7_1	0.7667
p.S417L	DO49964	CESC	ICGC	VLKTPITS	DEG_SCF_FBW7_1	0.7667
p.S409L	TCGA-FW-A3R5	SKCM	TCGA	VLKTPITS	DEG_SCF_FBW7_1	0.3056
p.S409L	DO37406	SKCM	ICGC	VLKTPITS	DEG_SCF_FBW7_1	0.3056
p.L403F	TCGA-GN-A4U8	SKCM	TCGA	VLKTPITS	DEG_SCF_FBW7_1	0.1389
p.L403F	DO47320	SKCM	ICGC	VLKTPITS	DEG_SCF_FBW7_1	0.1389
p.E403D	DO50341	ESAD	ICGC	VLKTPITS	DEG_SCF_FBW7_1	0.1389
p.N402K	DO229008	LICA	ICGC	VLKTPITS	DEG_SCF_FBW7_1	0.1111
p.S423N	DO232224	PBCA	ICGC	VLKTPITS	DEG_SCF_FBW7_1	0.1667
p.P422S	DO218863	SKCA	ICGC	VLKTPITS	DEG_SCF_FBW7_1	0.1944
p.P420S	DO52402	UCEC	ICGC	VLKTPITS	DEG_SCF_FBW7_1	0.25
p.A422T	DO42953	UCEC	ICGC	VLKTPITS	DEG_SCF_FBW7_1	0.1944
p.A422T	DO43971	UCEC	ICGC	VLKTPITS	DEG_SCF_FBW7_1	0.1944
p.G405E	DO41903	UCEC	ICGC	VLKTPITS	DEG_SCF_FBW7_1	0.1944
p.K416N	DO42713	UCEC	ICGC	VLKTPITS	DEG_SCF_FBW7_1	0.6918
p.S425C	ACH-000299	Leukemia	CCLE	VLKTPITS	DEG_SCF_FBW7_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15911	Zinc finger homeobox protein 3	DEG_SCF_FBW7_1	410:417	VLKTPITS	FBXW7	0.8779	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons