DegronMD - Q9NZ56(FMN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1247S	TCGA-18-3409	LUSC	TCGA	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.2778
p.P1247S	DO26444	LUSC	ICGC	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.2778
p.E107K	TCGA-3N-A9WC	SKCM	TCGA	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.1111
p.E107K	DO51234	SKCM	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.1111
p.V1259G	TCGA-43-A56V	LUSC	TCGA	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.1667
p.V1259G	DO45535	LUSC	ICGC	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.1667
p.A508V	TCGA-77-8144	LUSC	TCGA	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.2778
p.A508V	DO26949	LUSC	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.2778
p.P1257Q	TCGA-95-7039	LUAD	TCGA	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.2222
p.P1257Q	DO23907	LUAD	ICGC	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.2222
p.G1242C	TCGA-AG-3882	READ	TCGA	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.1389
p.G1242C	DO36724	READ	ICGC	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.1389
p.P1257S	TCGA-B5-A3FA	UCEC	TCGA	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.2222
p.P1257S	DO52402	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.2222
p.A526V	TCGA-CC-A9FU	LIHC	TCGA	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.0556
p.A526V	DO52190	LIHC	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.0556
p.S122G	TCGA-CR-7388	HNSC	TCGA	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation altering degron motif	0.6993
p.S122G	DO14284	HNSC	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation altering degron motif	0.6993
p.L503Q	TCGA-DD-AAE2	LIHC	TCGA	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.1389
p.L503Q	DO52256	LIHC	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.1389
p.P1255R	TCGA-DD-AAVZ	LIHC	TCGA	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.2778
p.P1255R	DO52285	LIHC	ICGC	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.2778
p.S113F	TCGA-EE-A29L	SKCM	TCGA	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.2778
p.S113F	DO37835	SKCM	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.2778
p.P1239S	TCGA-EE-A3AH	SKCM	TCGA	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.0556
p.P1239S	DO222635	MELA	ICGC	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.0556
p.P1239S	DO37443	SKCM	ICGC	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.0556
p.P1247Q	TCGA-ER-A19C	SKCM	TCGA	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.2778
p.P1247Q	DO47353	SKCM	ICGC	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.2778
p.A125V	TCGA-F4-6856	COAD	TCGA	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.25
p.A125V	DO9114	COAD	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.25
p.A125V	DO52664	MALY	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.25
p.P119S	TCGA-FR-A69P	SKCM	TCGA	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation altering degron motif	0.6752
p.P119S	DO47292	SKCM	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation altering degron motif	0.6752
p.L123F	TCGA-FR-A726	SKCM	TCGA	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.3056
p.L123F	DO220866	MELA	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.3056
p.L123F	DO48665	SKCM	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.3056
p.F1262L	TCGA-FR-A8YC	SKCM	TCGA	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.0833
p.F1262L	DO50301	SKCM	ICGC	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.0833
p.P1257T	TCGA-FS-A1Z0	SKCM	TCGA	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.2222
p.P1257T	DO37431	SKCM	ICGC	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.2222
p.G1261V	TCGA-HU-A4GU	STAD	TCGA	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.1111
p.G1261V	DO47849	STAD	ICGC	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.1111
p.L115V	DO219012	BLCA	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation altering degron motif	0.5654
p.V507L	DO222857	BTCA	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.25
p.A500T	DO7990	COAD	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.0556
p.R505H	DO234323	ESAD	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.1944
p.R505H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.1944
p.S1251G	DO233241	GACA	ICGC	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation altering degron motif	0.6993
p.S124P	DO233935	GACA	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.2778
p.S1252I	DO228948	LICA	ICGC	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation altering degron motif	0.7341
p.L131F	DO229041	LICA	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.0833
p.D108Y	DO223918	LIHC	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.1389
p.D108Y	DO219138	LUSC	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.1389
p.L123I	DO23196	LINC	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.3056
p.A111V	DO50813	LIRI	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.2222
p.R505S	DO224594	LUSC	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.1944
p.G512V	DO32851	PACA	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation altering degron motif	0.7532
p.L503M	DO229216	THCA	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.1389
p.D510N	DO229218	THCA	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation altering degron motif	0.6932
p.A526D	DO229221	THCA	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.0556
p.P517Q	DO229245	THCA	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.3056
p.A508E	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.2778
p.A508E	ACH-000697	Lymphoma	CCLE	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.2778
p.G106E	SIDM01149	Small Cell Lung Carcinoma	GDSC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.0833
p.G106E	ACH-001365	Lung Cancer	CCLE	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.0833
p.G106E	NCI-H847	lung	COSMIC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.0833
p.S122I	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation altering degron motif	0.7341
p.S122I	ACH-000434	Lung Cancer	CCLE	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation altering degron motif	0.7341
p.S122I	NCI-H1915	lung	COSMIC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation altering degron motif	0.7341
p.S113Y	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.2778
p.S113Y	ACH-000951	Lung Cancer	CCLE	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.2778
p.S113Y	NCI-H2342	lung	COSMIC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.2778
p.T1256A	SIDM01059	Melanoma	GDSC	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.25
p.T1256A	ACH-000915	Skin Cancer	CCLE	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.25
p.T1256A	IPC-298	skin	COSMIC	VGSST	DEG_SPOP_SBC_1	1249:1253	Mutation rewiring degron network	0.25
p.A111T	SIDM01664	Prostate Carcinoma	GDSC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.2222
p.A111T	ACH-000952	Prostate Cancer	CCLE	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.2222
p.G506W	ACH-000945	Lung Cancer	CCLE	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.2222
p.A500V	ACH-000954	Endometrial/Uterine Cancer	CCLE	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.0556
p.A500V	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGGGVS	DEG_SCF_TRCP1_1	510:516	Mutation rewiring degron network	0.0556
p.F114C	Mewo	skin	COSMIC	LTKTPDLS	DEG_SCF_FBW7_1	115:122	Mutation rewiring degron network	0.3056

Kaplan plot for FMN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FMN2

UniProt ID: Q9NZ56

Entrez ID: 56776

Protein name: Formin-2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FMN2 in