DegronMD

Uniprot ID: Q9NZ56

Source protein: Formin-2

Source gene: FMN2

Class: DEG_SCF_TRCP1_1

Location: 510:516

E3 ligase: BTRC

DEGRON score: 0.997

ASA_SCORE: 66.4714

COIL: 0.9131

CONS_SCORE: 0.4229

DSS_SCORE: 0.4066

HELIX: 0.0297

FCONS_SCORE: 0.9658

RIG_SCORE: 0.5944

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G512V	DO32851	PACA	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	0.7532
p.D510N	DO229218	THCA	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	0.6932
p.P517Q	DO229245	THCA	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	0.3056
p.A508V	TCGA-77-8144	LUSC	TCGA	DSGGGVS	DEG_SCF_TRCP1_1	0.2778
p.A508V	DO26949	LUSC	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	0.2778
p.A508E	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGGGVS	DEG_SCF_TRCP1_1	0.2778
p.A508E	ACH-000697	Lymphoma	CCLE	DSGGGVS	DEG_SCF_TRCP1_1	0.2778
p.V507L	DO222857	BTCA	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	0.25
p.G506W	ACH-000945	Lung Cancer	CCLE	DSGGGVS	DEG_SCF_TRCP1_1	0.2222
p.R505H	DO234323	ESAD	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	0.1944
p.R505H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGGGVS	DEG_SCF_TRCP1_1	0.1944
p.R505S	DO224594	LUSC	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	0.1944
p.L503Q	TCGA-DD-AAE2	LIHC	TCGA	DSGGGVS	DEG_SCF_TRCP1_1	0.1389
p.L503Q	DO52256	LIHC	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	0.1389
p.L503M	DO229216	THCA	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	0.1389
p.A526V	TCGA-CC-A9FU	LIHC	TCGA	DSGGGVS	DEG_SCF_TRCP1_1	0.0556
p.A526V	DO52190	LIHC	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	0.0556
p.A500T	DO7990	COAD	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	0.0556
p.A526D	DO229221	THCA	ICGC	DSGGGVS	DEG_SCF_TRCP1_1	0.0556
p.A500V	ACH-000954	Endometrial/Uterine Cancer	CCLE	DSGGGVS	DEG_SCF_TRCP1_1	0.0556
p.A500V	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGGGVS	DEG_SCF_TRCP1_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZ56	Formin-2	DEG_SCF_TRCP1_1	510:516	DSGGGVS	BTRC	0.997	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons