DegronMD

Uniprot ID: Q9NZ56

Source protein: Formin-2

Source gene: FMN2

Class: DEG_SCF_FBW7_1

Location: 115:122

E3 ligase: FBXW7

DEGRON score: 0.9119

ASA_SCORE: 77.3625

COIL: 0.7728

CONS_SCORE: 0.4276

DSS_SCORE: 0.4824

HELIX: 0.1253

FCONS_SCORE: 0.9827

RIG_SCORE: 0.7331

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E107K	TCGA-3N-A9WC	SKCM	TCGA	LTKTPDLS	DEG_SCF_FBW7_1	0.1111
p.E107K	DO51234	SKCM	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	0.1111
p.S122G	TCGA-CR-7388	HNSC	TCGA	LTKTPDLS	DEG_SCF_FBW7_1	0.6993
p.S122G	DO14284	HNSC	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	0.6993
p.S113F	TCGA-EE-A29L	SKCM	TCGA	LTKTPDLS	DEG_SCF_FBW7_1	0.2778
p.S113F	DO37835	SKCM	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	0.2778
p.A125V	TCGA-F4-6856	COAD	TCGA	LTKTPDLS	DEG_SCF_FBW7_1	0.25
p.A125V	DO9114	COAD	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	0.25
p.A125V	DO52664	MALY	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	0.25
p.P119S	TCGA-FR-A69P	SKCM	TCGA	LTKTPDLS	DEG_SCF_FBW7_1	0.6752
p.P119S	DO47292	SKCM	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	0.6752
p.L123F	TCGA-FR-A726	SKCM	TCGA	LTKTPDLS	DEG_SCF_FBW7_1	0.3056
p.L123F	DO220866	MELA	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	0.3056
p.L123F	DO48665	SKCM	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	0.3056
p.L115V	DO219012	BLCA	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	0.5654
p.S124P	DO233935	GACA	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	0.2778
p.L131F	DO229041	LICA	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	0.0833
p.D108Y	DO223918	LIHC	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	0.1389
p.D108Y	DO219138	LUSC	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	0.1389
p.L123I	DO23196	LINC	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	0.3056
p.A111V	DO50813	LIRI	ICGC	LTKTPDLS	DEG_SCF_FBW7_1	0.2222
p.G106E	SIDM01149	Small Cell Lung Carcinoma	GDSC	LTKTPDLS	DEG_SCF_FBW7_1	0.0833
p.G106E	ACH-001365	Lung Cancer	CCLE	LTKTPDLS	DEG_SCF_FBW7_1	0.0833
p.G106E	NCI-H847	lung	COSMIC	LTKTPDLS	DEG_SCF_FBW7_1	0.0833
p.S122I	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	LTKTPDLS	DEG_SCF_FBW7_1	0.7341
p.S122I	ACH-000434	Lung Cancer	CCLE	LTKTPDLS	DEG_SCF_FBW7_1	0.7341
p.S122I	NCI-H1915	lung	COSMIC	LTKTPDLS	DEG_SCF_FBW7_1	0.7341
p.S113Y	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LTKTPDLS	DEG_SCF_FBW7_1	0.2778
p.S113Y	ACH-000951	Lung Cancer	CCLE	LTKTPDLS	DEG_SCF_FBW7_1	0.2778
p.S113Y	NCI-H2342	lung	COSMIC	LTKTPDLS	DEG_SCF_FBW7_1	0.2778
p.A111T	SIDM01664	Prostate Carcinoma	GDSC	LTKTPDLS	DEG_SCF_FBW7_1	0.2222
p.A111T	ACH-000952	Prostate Cancer	CCLE	LTKTPDLS	DEG_SCF_FBW7_1	0.2222
p.F114C	Mewo	skin	COSMIC	LTKTPDLS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTKTPDLS

Degron related mutations and impact score

Drug responses associated with FMN2 mutations

All proteins holding degron of LTKTPDLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZ56	Formin-2	DEG_SCF_FBW7_1	115:122	LTKTPDLS	FBXW7	0.9119	More...