DegronMD - Q9BSJ2(TUBGCP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T146S	TCGA-37-5819	LUSC	TCGA	LRKQLGSVA	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.3056
p.T146S	DO26479	LUSC	ICGC	LRKQLGSVA	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.3056
p.M131I	TCGA-66-2756	LUSC	TCGA	LRKQLGSVA	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.1667
p.M131I	DO27128	LUSC	ICGC	LRKQLGSVA	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.1667
p.A124G	TCGA-AJ-A3EK	UCEC	TCGA	VGSST	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1389
p.A124G	DO41584	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1389
p.K103T	TCGA-AP-A059	UCEC	TCGA	VGSST	DEG_SPOP_SBC_1	113:117	Mutation blocking ubiquitination signal	0.5
p.K103T	DO41361	UCEC	ICGC	VGSST	DEG_SPOP_SBC_1	113:117	Mutation blocking ubiquitination signal	0.5
p.V144M	TCGA-G4-6304	COAD	TCGA	LRKQLGSVA	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.6097
p.V144M	DO10639	COAD	ICGC	LRKQLGSVA	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.6097
p.V144M	DO233913	GACA	ICGC	LRKQLGSVA	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.6097
p.A110G	TCGA-S3-AA12	BRCA	TCGA	VGSST	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.25
p.A110G	DO51224	BRCA	ICGC	VGSST	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.25
p.S115N	TCGA-UF-A71A	HNSC	TCGA	VGSST	DEG_SPOP_SBC_1	113:117	Mutation altering degron motif	0.7069
p.S115N	DO52106	HNSC	ICGC	VGSST	DEG_SPOP_SBC_1	113:117	Mutation altering degron motif	0.7069
p.G142A	DO48385	BLCA	ICGC	LRKQLGSVA	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.6429
p.S119G	DO225005	BRCA	ICGC	VGSST	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2778
p.Q152K	DO229032	LICA	ICGC	LRKQLGSVA	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.1389
p.A112V	DO229248	THCA	ICGC	VGSST	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.3056
p.I129V	SIDM00863	Burkitt's Lymphoma	GDSC	LRKQLGSVA	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.1111
p.I129V	ACH-000877	Lymphoma	CCLE	LRKQLGSVA	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.1111
p.I129V	ACH-001064	Lymphoma	CCLE	LRKQLGSVA	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.1111
p.I129V	EB2	haematopoietic and lymphoid tissue	COSMIC	LRKQLGSVA	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.1111
p.A128V	JEG-3	placenta	COSMIC	LRKQLGSVA	DEG_APCC_DBOX_1	137:145	Mutation substituting flanking lysine	0.1944
p.R114L	NCI-H322M	lung	COSMIC	VGSST	DEG_SPOP_SBC_1	113:117	Mutation altering degron motif	0.8428
p.P142S	K2	skin	COSMIC	LRKQLGSVA	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.6752
p.E131K	NCI-H2342	lung	COSMIC	LRKQLGSVA	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.1667

Kaplan plot for TUBGCP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TUBGCP2

UniProt ID: Q9BSJ2

Entrez ID: 10844

Protein name: Gamma-tubulin complex component 2 (GCP-2) (hGCP2) (Gamma-ring complex protein 103 kDa) (h103p) (hGrip103) (Spindle pole body protein Spc97 homolog) (hSpc97)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TUBGCP2 in